Interplay of neuronal processes during response inhibition: Results from a combined event-related potentials (ERPs)/transcranial magnetic stimulation (TMS) study on methylphenidate

Hoegl, Thomas; Heinrich, Hartmut; Albrecht, Björn; Diruf, Martin; Moll, Gunther H.; Kratz, Oliver

doi:10.1016/j.ijpsycho.2011.05.004

Cited by 9 publications

(11 citation statements)

References 51 publications

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“…However, this may be not the case, as interindividually faster responding was associated with enhanced Nogo‐P3 which may reflect higher need for response inhibition and consequently more resource allocation in individuals responding faster. Similarly, a recent study using transcranial magnetic stimulation in healthy adults shows that increased Nogo‐P3 may compensate deficient inhibitory processes within the motor system (Hoegl et al., ). Albeit this study gives no evidence for increased impulsivity from performance data or psychopathology, the increased Nogo‐P3 in children with the DAT1 10‐6 haplotype may reflect a compensatory neuronal response inhibition process.…”

Section: Discussionmentioning

confidence: 91%

Genetics of preparation and response control in ADHD: the role of DRD4 and DAT1

Albrecht

Brandeis

Sandersleben

et al. 2014

Child Psychology Psychiatry

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This study detected specific effects of DRD4 7R on performance and brain activity related to attentional orienting and response preparation, while DAT1 10-6 was associated with elevated brain activity related to inhibitory response control, which potentially compensates increased impulsivity. As these genotype effects were additive to the impact of ADHD, the current results indicate that DRD4 and DAT1 polymorphisms are functionally relevant risk factors for ADHD and presumably other disorders sharing these endophenotypes.

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Section: Discussionmentioning

confidence: 91%

Genetics of preparation and response control in ADHD: the role of DRD4 and DAT1

Albrecht

Brandeis

Sandersleben

et al. 2014

Child Psychology Psychiatry

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“…Trials with amplitudes >100 µV as well as with omission and false alarm errors were excluded from final averaging over the same task condition (attention, go, and nogo). ERP scoring for CNV, N1, N2, and P3 was computed as the mean amplitude for specific intervals and locations selected by visual inspection of the grand mean ERP averages of the EEG data and further in accordance with prior studies (Heinrich et al, ; Hoegl et al, ): N1 from 60 to 110 ms, N2 from 170 to 280 ms, and P3 from 250 to 400 ms; N1 at Fz and N2, P3 either at Cz after nogo signal or at Pz after cue or go signal; CNV at FZ from 100 to 0 ms before go or nogo signal.…”

Section: Methodsmentioning

confidence: 99%

“…MPH affects working memory, processing speed, verbal learning, attention, and vigilance (Linssen, Sambeth, Vuurman, & Riedel, ). That was proven by a study wherein a go/nogo task was performed by healthy adults and ERP and TMS measures were taken (Hoegl et al, ). For ERP, authors found an increased response evaluation indexed by an elevated P3 under MPH, but only for go trials, and not for nogo trials.…”

Section: Introductionmentioning

confidence: 99%

Methylphenidate promotes the interaction between motor cortex facilitation and attention in healthy adults: A combined study using event‐related potentials and transcranial magnetic stimulation

et al. 2018

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ObjectiveThis study investigated simultaneously the impact of methylphenidate (MPH) on the interaction of inhibitory and facilitative pathways in regions processing motor and cognitive functions.MethodNeural markers of attention and response control (event‐related potentials) and motor cortical excitability (transcranial magnetic stimulation) and their pharmacological modulation by MPH were measured simultaneously in a sample of healthy adults (n = 31) performing a cued choice reaction test.ResultsMethylphenidate modulated attentional gating and response preparation processes (increased contingent negative variation) and response inhibition (increased nogo P3). N1, cue‐ and go‐P3 were not affected by MPH. Motor cortex facilitation, measured with long‐interval cortical facilitation, was increased under MPH in the nogo condition and was positively correlated with the P3 amplitude.ConclusionMethylphenidate seems particularly to enhance response preparation processes. The MPH‐induced increased motor cortex facilitation during inhibitory task demands was accompanied by increased terminal response inhibition control, probably as a compensatory process.

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“…Neurochemical changes in large networks have been observed in PET data showing that methylphenidate can induce significant DA increases in striatum, amygdala and the medial orbitofrontal cortex (Volkow et al, 2013). EEG, TMS and fMRI studies have further demonstrated the ability of methylphenidate to modulate neuroelectrical properties at different spatial levels (Hoegl et al, 2011; Silberstein et al, 2016). Future studies are needed to elucidate these interactions before tES protocols that take these interactions into account can be designed.…”

Section: Mechanistic Levels Of Tes Effectsmentioning

confidence: 99%

Transcranial Electric Stimulation for Precision Medicine: A Spatiomechanistic Framework

Yavari

Nitsche

Ekhtiari

2017

Front. Hum. Neurosci.

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During recent years, non-invasive brain stimulation, including transcranial electrical stimulation (tES) in general, and transcranial direct current stimulation (tDCS) in particular, have created new hopes for treatment of neurological and psychiatric diseases. Despite promising primary results in some brain disorders, a more widespread application of tES is hindered by the unsolved question of determining optimum stimulation protocols to receive meaningful therapeutic effects. tES has a large parameter space including various montages and stimulation parameters. Moreover, inter- and intra-individual differences in responding to stimulation protocols have to be taken into account. These factors contribute to the complexity of selecting potentially effective protocols for each disorder, different clusters of each disorder, and even each single patient. Expanding knowledge in different dimensions of basic and clinical neuroscience could help researchers and clinicians to select potentially effective protocols based on tES modulatory mechanisms for future clinical studies. In this article, we propose a heuristic spatiomechanistic framework which contains nine levels to address tES effects on brain functions. Three levels refer to the spatial resolution (local, small-scale networks and large-scale networks) and three levels of tES modulatory effects based on its mechanisms of action (neurochemical, neuroelectrical and oscillatory modulations). At the group level, this framework could be helpful to enable an informed and systematic exploration of various possible protocols for targeting a brain disorder or its neuroscience-based clusters. Considering recent advances in exploration of neurodiversity at the individual level with different brain mapping technologies, the proposed framework might also be used in combination with personal data to design individualized protocols for tES in the context of precision medicine in the future.

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Interplay of neuronal processes during response inhibition: Results from a combined event-related potentials (ERPs)/transcranial magnetic stimulation (TMS) study on methylphenidate

Cited by 9 publications

References 51 publications

Genetics of preparation and response control in ADHD: the role of DRD4 and DAT1

Genetics of preparation and response control in ADHD: the role of DRD4 and DAT1

Methylphenidate promotes the interaction between motor cortex facilitation and attention in healthy adults: A combined study using event‐related potentials and transcranial magnetic stimulation

Transcranial Electric Stimulation for Precision Medicine: A Spatiomechanistic Framework

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