Interplay Between miR-155, AT1R A1166C Polymorphism, and AT1R Expression in Young Untreated Hypertensives

Ceolotto, Giulio; Papparella, Italia; Bortoluzzi, Alessia; Strapazzon, Giacomo; Ragazzo, Fabio; Bratti, Paolo; Fabricio, Aline S C; Squarcina, E; Gion, Massimo; Palatini, Paolo; Semplicini, Andrea

doi:10.1038/ajh.2010.211

Cited by 134 publications

(97 citation statements)

References 30 publications

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“…Several studies have postulated that A1166C is merely a marker of cardiovascular risk, as it is located in a noncoding 3′-untranslated region (UTR) of the AGTR1 gene (Ceolotto et al 2010). However, the A1166C polymorphism is located in a cis-regulatory site that influences posttranscriptional protein expression through complementary base pairing with microRNA (miRNA; Sethupathy et al 2007).…”

Section: Discussionmentioning

confidence: 99%

“…However, the A1166C polymorphism is located in a cis-regulatory site that influences posttranscriptional protein expression through complementary base pairing with microRNA (miRNA; Sethupathy et al 2007). Interestingly, only the A1166 variant is recognized by a specific miRNA known as miR-155, causing downregulation of receptor expression (Sethupathy et al 2007;Ceolotto et al 2010). Recent evidence suggests that the interaction between miRNA and SNP expression may be due to the combination of modified miRNA sequence and 3′UTR secondary structure disruption, thus altering accessibility of the recognition site and implicating a potential role for SNPs in linkage disequilibrium with A1166C (Haas et al 2012).…”

Section: Discussionmentioning

confidence: 99%

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Impact of the AGTR1 A1166C polymorphism on subcortical hyperintensities and cognition in healthy older adults

Salminen

Schofield

Pierce

et al. 2014

AGE

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Vascular aging consists of complex and multifaceted processes that may be influenced by genetic polymorphisms of the renin-angiotensin system. A polymorphism in the angiotensin II type 1 receptor gene (AGTR1/rs5186) has been associated with an increased risk for arterial stiffness, hypertension, and ischemic stroke. Despite these identified relationships, the impact of AGTR1 A1166C on white matter integrity and cognition is less clear in a healthy aging population. The present study utilized indices of neuroimaging and neuropsychological assessment to examine the impact of the A1166C polymorphism on subcortical hyperintensities (SH) and cognition in 49 healthy adults between ages 51-85. Using a dominant statistical model (CC + CA (risk) vs. AA), results revealed significantly larger SH volume for individuals with the C1166 variant (p<0.05, partial eta 2 = 0.117) compared with those with the AA genotype. Post hoc analyses indicated that increased SH volume in C allele carriers could not be explained by vascular factors such as pulse pressure or body mass index. In addition, cognitive performance did not differ significantly between groups and was not significantly associated with SH in this cohort. Results suggest that presence of the C1166 variant may serve as a biomarker of risk for suboptimal brain integrity in otherwise healthy older adults prior to changes in cognition.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impact of the AGTR1 A1166C polymorphism on subcortical hyperintensities and cognition in healthy older adults

Salminen

Schofield

Pierce

et al. 2014

AGE

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show abstract

“…[19] Finally, miR-9 (but not miR-126) also correlated positively with left ventricular mass index. [19] Elsewhere, Ceolotto et al [20] correlations remained significant after correction for 24-hour systolic or diastolic blood pressure. [23] Whilst further validation is clearly required, these findings suggest that microRNAs (or panels of microRNAs) herald great potential to identify target-organ damage in hypertension, independent of blood pressure.…”

Section: Circulating Micrornas and Existing Mechanisms Of Blood Pressmentioning

confidence: 97%

Circulating microRNAs and hypertension—from new insights into blood pressure regulation to biomarkers of cardiovascular risk

Romaine

Charchar

Samani

et al. 2016

Current Opinion in Pharmacology

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“…Functional studies showed that this polymorphism was recognized by a specific micro-RNA-155 which is base-pairing complementary with the 1166A allele but not with the mutant 1166C allele. 7,8 Manystudies have examined the association between AGTR1 gene A1166C polymorphism and CAD; the results, however, remain controversial mainly due to insufficient sample sizes, inappropriate selection of patients and controls, population stratification and admixture, ethnicityspecific genetic backgrounds and lack of adjustment for confounders. 9 Given the accumulation of data, we conducted a meta-analysis of published studies on the association of A1166C polymorphism with CAD in Chinese, and explored the potential sources of between-heterogeneity and possible existence of publication bias.…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of the association between angiotensin II receptor, type 1 gene A1166C polymorphism and coronary artery disease in Chinese populations

Nan

et al. 2012

J Renin Angiotensin Aldosterone Syst

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Background and objective:Many studies have examined the association between the angiotensin II receptor, type 1 (AGTR1) gene A1166C polymorphism and coronary artery disease (CAD); the results, however, remain controversial. Given the accumulation of data, we conducted a meta-analysis of published studies on this association in Chinese. Methods and results:A comprehensive search of PubMed, Wanfang and Chinese National Knowledge Infrastructure (CNKI) databases was conducted before January 2012. Data and study quality were assessed in duplicate. Twenty-two studies totaling 3502 CAD patients and 3071 controls were analyzed. Overall, individuals carrying 1166C allele had a remarkably increased risk of CAD compared with those with 1166AA genotype (odds ratio (OR)=1.63; 95% confidence interval (CI): 1.26-2.1; P<0.0005). In subgroup analyses by geography, the risk magnitude was slightly augmented in northern Chinese (OR=1.76; 95% CI: 1.23-2.52; P=0.002) relative to in southern Chinese (OR=1.55; 95% CI: 1.13-2.14; P=0.007). Grouping studies by average age detected a strong association in studies involving CAD patients aged ≥ 60 years. Differences in the diagnosis of CAD and source of controls might be potential sources of between-study heterogeneity. Conclusions: Our findings provided strong evidence that AGTR1 gene A1166C polymorphism might be a genetic marker for the development of CAD in Chinese populations, especially in the context of studies with northern and older subjects.

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Interplay Between miR-155, AT1R A1166C Polymorphism, and AT1R Expression in Young Untreated Hypertensives

Abstract: The interplay between miR-155 expression, +1166C polymorphism, and AT1R protein expression may have a role in the regulation of blood pressure.

Cited by 134 publications

References 30 publications

Impact of the AGTR1 A1166C polymorphism on subcortical hyperintensities and cognition in healthy older adults

Impact of the AGTR1 A1166C polymorphism on subcortical hyperintensities and cognition in healthy older adults

Circulating microRNAs and hypertension—from new insights into blood pressure regulation to biomarkers of cardiovascular risk

Meta-analysis of the association between angiotensin II receptor, type 1 gene A1166C polymorphism and coronary artery disease in Chinese populations

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