Meta-analysis of the association between angiotensin II receptor, type 1 gene A1166C polymorphism and coronary artery disease in Chinese populations

Abstract

Background and objective:Many studies have examined the association between the angiotensin II receptor, type 1 (AGTR1) gene A1166C polymorphism and coronary artery disease (CAD); the results, however, remain controversial. Given the accumulation of data, we conducted a meta-analysis of published studies on this association in Chinese. Methods and results:A comprehensive search of PubMed, Wanfang and Chinese National Knowledge Infrastructure (CNKI) databases was conducted before January 2012. Data and study quality were assessed in duplicate. Twenty-two studies totaling 3502 CAD patients and 3071 controls were analyzed. Overall, individuals carrying 1166C allele had a remarkably increased risk of CAD compared with those with 1166AA genotype (odds ratio (OR)=1.63; 95% confidence interval (CI): 1.26-2.1; P<0.0005). In subgroup analyses by geography, the risk magnitude was slightly augmented in northern Chinese (OR=1.76; 95% CI: 1.23-2.52; P=0.002) relative to in southern Chinese (OR=1.55; 95% CI: 1.13-2.14; P=0.007). Grouping studies by average age detected a strong association in studies involving CAD patients aged ≥ 60 years. Differences in the diagnosis of CAD and source of controls might be potential sources of between-study heterogeneity. Conclusions: Our findings provided strong evidence that AGTR1 gene A1166C polymorphism might be a genetic marker for the development of CAD in Chinese populations, especially in the context of studies with northern and older subjects.

Association of Four Genetic Polymorphisms of AGER and Its Circulating Forms with Coronary Artery Disease: A Meta-Analysis

“…For example, risk estimate of 82Ser allele on CAD was 1.29 in East Asians, but was 0.9 in Caucasians. A possible explanation may be due to divergent genetic backgrounds or linkage patterns, and usually a variant is in close linkage with another nearby causal variant in one ethnic group but not in another [43], [44]. As a consequence, there is a need to construct a database of CAD-susceptibility genes or variants in each racial/ethnic group.…”

Analysis of correlations between coronary heart disease and haplotypes of the angiotensin II receptor type 1 (AGTR1) gene

“…It is generally accepted that angiotensin II is involved in the pathogenesis of hypertension; less well recognized is its involvement in that of atherosclerosis (Rosei, 2008). Some studies have reported a correlation between AGTR1 genetic variants and CHD (Tiret et al, 1994;Abd El-Aziz et al, 2012;Li et al, 2013). In particular, several have demonstrated a close association between the A1166C polymorphism and CHD incidence (Nakauchi et al, 1996;Buraczyńska et al, 2003;Abd El-Aziz et al, 2012).…”

Prognostic Role of A1166c Polymorphisms of the Angiotensine Ii Receptor Gene (Agt2r1) in Coronary Atherosclerosis Among Adyghea Republic Inhabitants

“…Вместе с тем, результаты многоцентровых исследований по ассо-циации SNP А1166С гена AGT2R1 с риском развития БСК для разных этнических групп противоречивы и неоднозначны. Единичные работы в России не отражают генетического разнообразия в распреде-лении 1166С полиморфизмов гена AGT2R1 и их ассо-циаций с ССЗ [8][9][10][11][12][13][14][15].…”

“…С1166С генотип и 1166С аллель ассоциированы с повышенным риском развития сердечно-сосудис-тых заболеваний и, в частности, коронарного атеро-склероза [9,10,12,14,15].…”