Interplay Between Liver Type 1 Innate Lymphoid Cells and NK Cells Drives the Development of Alcoholic Steatohepatitis

Cheng, Chen; Zhang, Qian; Li, Yue; Jiang, Jiali; Xie, Linxi; Shen, Haiyuan; Wu, Dongqing; Zhang, Hejiao; Zhang, Huiru; Wang, Xuan; H, Wu; Xu, Jingjing; Gui, Li; Li, Bao; Ju, Cynthia; Peng, Hui; Yin, Shan; Xu, Long

doi:10.1016/j.jcmgh.2022.09.010

Cited by 5 publications

(4 citation statements)

References 39 publications

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“…In contrast, hepatic ILC1 promoted the development and aggravation of steatohepatitis through the secretion of IL-17. 69 In parallel, NK-cell-derived IFN-γ, which is significantly downregulated after chronic alcohol consumption, inhibits IL-17 A production. This study highlighted the protective role of NK cells in ALD, whereas ILC1 appeared to be deleterious.…”

Section: Nk Cells and Ilc1 In Aldmentioning

confidence: 99%

“… 66 Furthermore, the relative contributions of murine hepatic NK cells and ILC during alcoholic steatohepatitis have recently been investigated. 69 Chronic (10-days chronic) plus single-binge ethanol feeding in mice induced apoptosis of NK cells resulting in ILC1 dominance and a negative outcome. Restoration of NK cells by cell transfer protected mice from alcohol-induced steatohepatitis, revealing the protective role of NK cells.…”

Section: Nk Cells and Ilc1 In Aldmentioning

confidence: 99%

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Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseases

Bourinet,

Anty,

Gual

et al. 2024

JHEP Reports

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Section: Nk Cells and Ilc1 In Aldmentioning

confidence: 99%

Section: Nk Cells and Ilc1 In Aldmentioning

confidence: 99%

Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseases

Bourinet,

Anty,

Gual

et al. 2024

JHEP Reports

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“…The role of hepatic lymphocytes in the pathogenesis of ALD has not received much attention thus far. In a recent study, the functional dysregulation between liver innate lymphoid cells (ILC1) and NK cells was found to cause a significant increase in IL-17 levels, thereby promoting the progression of alcohol-related fatty liver disease 52 . Similarly, T-cell activation is closely associated with epigenetic regulation.…”

Section: Epigenetic Regulatory Mechanisms Of Alcohol Consumption On T...mentioning

confidence: 99%

Unraveling the Complex Interplay between Epigenetics and Immunity in Alcohol-Associated Liver Disease: A Comprehensive Review

Liu,

Zhang

et al. 2023

Int. J. Biol. Sci.

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The mechanisms of immune dysfunction in alcohol-associated liver disease (ALD) have garnered growing research interest in recent times. Alcohol-mediated immune dysfunction has been implicated as a potential cause of ALD-associated microbial infection and inflammatory response. The immune microenvironment of an organism is essentially a complex network of interactions between immune cells, cytokines, extracellular matrix, and other immune-related molecules. This microenvironment is highly adaptive and responsive to environmental cues. Epigenetic reprogramming of the immune microenvironment has recently emerged as a key driver of ALD progression, particularly in the context of endotoxin tolerance and immune disorders. Although epigenetic modifications are known to play an important role in the regulation of the immune microenvironment in ALD, the specific mechanisms and molecular processes by which this regulation is achieved are yet to be fully understood. This paper aims to provide an overview of the current knowledge on the effects of alcohol consumption on epigenetics, with special focus on summarizing the data on the epigenetic regulatory mechanisms involved in the effects of alcohol consumption on the immune microenvironment. In addition, this paper aims to present a review of the epigenetic modifications involved in different forms of ALD. This review is expected to offer new perspectives for the diagnosis, treatment, monitoring, and prognostic assessment of ALD from an epigenetic perspective.

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“…In this issue of Cellular and Molecular Gastroenterology and Hepatology , Cheng et al 8 provide an important insight into understanding the pathophysiology of alcohol-associated steatohepatitis. They suggest that the dysfunctional interplay between hepatic ILC1 and NK cells results in highly elevated levels of IL-17, promoting the progression of alcohol-associated steatohepatitis.…”

mentioning

confidence: 99%

Innate Lymphoid Cells: New Culprits of Alcohol-Associated Steatohepatitis

Choi¹,

Jeong²

2023

Cellular and Molecular Gastroenterology and Hepatology

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Interplay Between Liver Type 1 Innate Lymphoid Cells and NK Cells Drives the Development of Alcoholic Steatohepatitis

Cited by 5 publications

References 39 publications

Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseases

Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseases

Unraveling the Complex Interplay between Epigenetics and Immunity in Alcohol-Associated Liver Disease: A Comprehensive Review

Innate Lymphoid Cells: New Culprits of Alcohol-Associated Steatohepatitis

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