Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities

Wang, Huan; Lin, Shiqi; Wu, Xiying; Jiang, Kuan; Lu, Huiping; Zhan, Changyou

doi:10.1002/advs.202301777

Cited by 7 publications

(1 citation statement)

References 130 publications

(166 reference statements)

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“…IgM is frequently observed in the coronas of liposomes, including the plasma samples obtained from patients treated with DOXIL [ 25 ]. IgM adsorption is an issue for PEGylated drugs (including DOXIL), because anti-PEG antibodies—the prevalence of which rose from 0.2% in 1984 to 97.5% in 2019 in treatment-naïve individuals [ 51 ]—cause rapid elimination of the drug from bloodstream, as well as may result in adverse effects associated with complement activation [ 17 , 18 ].…”

Section: Resultsmentioning

confidence: 99%

Protein Corona of Anionic Fluid-Phase Liposomes Compromises Their Integrity Rather than Uptake by Cells

et al. 2023

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Despite the undisputable role of the protein corona in the biointeractions of liposome drug carriers, the field suffers from a lack of knowledge regarding the patterns of protein deposition on lipid surfaces with different compositions. Here, we investigated the protein coronas formed on liposomes of basic compositions containing combinations of egg phosphatidylcholine (PC), palmitoyloleoyl phosphatidylglycerol (POPG), and cholesterol. Liposome−protein complexes isolated by size-exclusion chromatography were delipidated and analyzed using label-free LC-MS/MS. The addition of the anionic lipid and cholesterol both affected the relative protein abundances (and not the total bound proteins) in the coronas. Highly anionic liposomes, namely those containing 40% POPG, carried corona enriched with cationic proteins (apolipoprotein C1, beta-2-glycoprotein 1, and cathelicidins) and were the least stable in the calcein release assay. Cholesterol improved the liposome stability in the plasma. However, the differences in the corona compositions had little effect on the liposome uptake by endothelial (EA.hy926) and phagocytic cells in the culture (U937) or ex vivo (blood-derived monocytes and neutrophils). The findings emphasize that the effect of protein corona on the performance of the liposomes as drug carriers occurs through compromising particle stability rather than interfering with cellular uptake.

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Section: Resultsmentioning

confidence: 99%

Protein Corona of Anionic Fluid-Phase Liposomes Compromises Their Integrity Rather than Uptake by Cells

et al. 2023

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Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities

Wang

Lin

et al. 2023

Advanced Science

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Liposomes have received tremendous attention as a class of versatile pharmaceutical vehicles of great potential over the past several decades. However, the application of liposomes encounters major challenges due to the knowledge gaps in their in vivo delivery process. Immunoglobulin M (IgM) displays both pervasiveness and complexity in regulating the biological functions as well as eliciting adverse effects of liposomes. Understanding, mitigating, and exploiting the duality of IgM are prerequisites for achieving various biomedical applications of liposomes. In this review, the intricate relationship between liposomes and their biological environments has been summarized, with an emphasis on the regulatory effects of IgM on in vivo performance of liposomes. Corresponding solutions have also been discussed to evade IgM‐mediated opsonization for safe and efficient drug delivery.

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Self‐Assembled Nanocarrier Delivery Systems for Bioactive Compounds

Zhang,

Ding

et al. 2024

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Although bioactive compounds (BCs) have many important functions, their applications are greatly limited due to their own defects. The development of nanocarriers (NCs) technology has gradually overcome the defects of BCs. NCs are equally important as BCs to some extent. Self‐assembly (SA) methods to build NCs have many advantages than chemical methods, and SA has significant impact on the structure and function of NCs. However, the relationship among SA mechanism, structure, and function has not been given enough attention. Therefore, from the perspective of bottom‐up building mechanism, the concept of SA‐structure‐function of NCs is emphasized to promote the development of SA‐based NCs. First, the conditions and forces for occurring SA are introduced, and then the SA basis and molecular mechanism of protein, polysaccharide, and lipid are summarized. Then, varieties of the structures formed based on SA are introduced in detail. Finally, facing the defects of BCs and how to be well solved by NCs are also elaborated. This review attempts to describe the great significance of constructing artificial NCs to deliver BCs from the aspects of SA‐structure‐function, so as to promote the development of SA‐based NCs and the wide application of BCs.

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Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities

Cited by 7 publications

References 130 publications

Protein Corona of Anionic Fluid-Phase Liposomes Compromises Their Integrity Rather than Uptake by Cells

Protein Corona of Anionic Fluid-Phase Liposomes Compromises Their Integrity Rather than Uptake by Cells

Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities

Self‐Assembled Nanocarrier Delivery Systems for Bioactive Compounds

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