Interplay between apoptosis and autophagy in colorectal cancer

Qian, Hao; Shi, Zhaoqi; Zhu, Hepan; Gu, Liang; Wang, Xianfa; Yang, Yi

doi:10.18632/oncotarget.18663

Cited by 45 publications

(34 citation statements)

References 89 publications

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“…It is well known that apoptosis is a strictly programmed cell death process, which serves a critical role in maintaining the balance between cell survival and death (18). Normally, apoptosis is a critically regulated physiological process; however, abnormal cellular proliferation and accumulation of genetic defects may occur in instances of impaired apoptotic mechanisms, which could further lead to tumorigenesis and resistance to treatment (19).…”

Section: Discussionmentioning

confidence: 99%

Gallic acid has anticancer activity and enhances the anticancer effects of cisplatin in non‑small cell lung cancer A549 cells via the JAK/STAT3 signaling pathway

Zhang¹,

Ma²,

Wu³

et al. 2019

Oncol Rep

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Gallic acid (3,4,5-trihydroxybenzoic acid; GA), a plant-derived natural phenolic compound, has been reported to prevent the development and progression of various types of cancers. However, there has been little elaboration of the anticancer effects and underlying mechanisms of GA alone and/or in combination with cisplatin in non-small cell lung cancer (NSCLC). The aim of the present study was to investigate the anticancer effects of GA on NSCLC A549 cells and its auxiliary effects on the anticancer activity of cisplatin. The results revealed that GA inhibited the proliferation and induced the apoptosis of NSCLC A549 cells in dose-and time-dependent manners, which was associated with upregulated B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax) and downregulated Bcl-2. Notably, the results also indicated that GA enhanced the anticancer effects of cisplatin in the inhibition of cancer cell proliferation and the induction of cell apoptosis following elevated Bax expression and suppressed Bcl-2 expression. Furthermore, the results of the present study also demonstrated that GA exerted independent anticancer effects on NSCLC A549 cells, and facilitated the anticancer effects of cisplatin by modulating the JAK/STAT3 signaling pathway and downstream apoptotic molecules. These results may serve as a rationale for further basic studies and preclinical investigations on the anticancer effects of GA and its auxiliary effects on cisplatin function in human NSCLC.

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Section: Discussionmentioning

confidence: 99%

Gallic acid has anticancer activity and enhances the anticancer effects of cisplatin in non‑small cell lung cancer A549 cells via the JAK/STAT3 signaling pathway

Zhang¹,

Ma²,

Wu³

et al. 2019

Oncol Rep

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“…Phase I and II clinical trials have already evaluated the efficacy of the combination of HCQ and chemotherapy ( e.g ., oxaliplatin, fluouropirimidines) and anti-angiogenic agents ( e.g ., bevacizumab) in mCRC patients. Furthermore, mCRC patients have achieved disease stabilization after combining HCQ with vorinostat[ 11 ]. Further elucidation of the effect of the currently existed as well as developing autophagy inhibitors in CRC patients is of paramount importance due to the dual role of autophagy in CRC.…”

Section: Autophagy In Clinical Practicementioning

confidence: 99%

Upgraded role of autophagy in colorectal carcinomas

Koustas

Sarantis

Papavassiliou

et al. 2018

WJGO

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Autophagy is a basic catabolic process closely associated with degradation of cellular components. The role of autophagy in colorectal cancer (CRC) remains controversial. The mechanism of autophagy has been identified as protecting mechanism against tumorigenesis by isolation of damaged organelles or as cytoprotective provides energy in hypoxic regions of CRC tumors. Mutations in proto-oncogenes, such as RAS and BRAF, have been associated with autophagy initiation through signaling pathways of BRAF/MEK/ERK and PI3K/AKT/mTOR. A combination therapy of chemotherapeutic agents and autophagy inhibitors such as hydroxychloroquine or immunotherapy might represent a major step that could be evaluated as a putative novel therapeutic strategy in CRC patients.

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“…Growing bodies of evidence have described cell death associated with autophagic features in response to various antitumor agents [ 17 , 18 ]. Thus, the intricate interplay between apoptosis and autophagy is considered to be two different death modalities that serve pivotal roles in the development of a therapeutic strategy for cancer treatment [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Coronarin D induces reactive oxygen species-mediated cell death in human nasopharyngeal cancer cells through inhibition of p38 MAPK and activation of JNK

et al. 2017

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Background and PurposeNasopharyngeal carcinoma (NPC) belongs to squamous cell carcinoma that occurs in the epithelial lining of the nasopharynx. Because of the anatomical position close to the cervical lymph node, some patients have a distant metastasis at the time of diagnosis that leads to treatment failure. Although early stages have a high curability and excellent prognosis, advanced NPC urgently requires new drugs developed to reinforce the effectiveness of therapy without noticeable side effects.Experimental approachCoronarin D (CD), a natural product extracted from the rhizomes of Hedychium coronarium, has been reported to possess anticancer potential. The aim of the present study was to determine the anticancer activity of CD and further elucidate the underlying molecular mechanisms.Key ResultsIn this study, we first demonstrated that CD potently suppressed cell viability in various NPC cell lines. Treatment of cells with CD induced G2/M arrest, apoptosis, and autophagy. Further studies showed that CD increased the production of reactive oxygen species and subsequently activated both autophagy and apoptosis. Moreover, we found that CD-induced activation of p38 and JNK constituted major mechanisms involved in the apoptosis and autophagy triggered by CD. In particular, inhibition of autophagy could strengthen the cytotoxicity of CD, implying that autophagy seems to play a valuable survival and protective role in cancer cells.Conclusions & ImplicationsThese findings provide a promise for the use of CD in combination with autophagy inhibitors for treatment of human NPC cell lines.

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Interplay between apoptosis and autophagy in colorectal cancer

Cited by 45 publications

References 89 publications

Gallic acid has anticancer activity and enhances the anticancer effects of cisplatin in non‑small cell lung cancer A549 cells via the JAK/STAT3 signaling pathway

Gallic acid has anticancer activity and enhances the anticancer effects of cisplatin in non‑small cell lung cancer A549 cells via the JAK/STAT3 signaling pathway

Upgraded role of autophagy in colorectal carcinomas

Coronarin D induces reactive oxygen species-mediated cell death in human nasopharyngeal cancer cells through inhibition of p38 MAPK and activation of JNK

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