Interpenetrating polymeric networks of chitosan and egg white with dual crosslinking agents polyethylene glycol/polyvinylpyrrolidone as a novel drug carrier

Priya, P. Gomathi; Raja, A. S.; Raj, V.

doi:10.1007/s10570-015-0821-x

Cited by 21 publications

(12 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A Bt S t = + (2) where A is reciprocal of initial swelling rate r o or 1=S max 2 k s and B is inverse of the weight-swelling ratio at equilibrium. To test the kinetic model, t/S vs. t graphs were plotted and the graphs are shown in Figure 1 (b).…”

Section: Kinetics Swelling Studiesmentioning

confidence: 99%

“…Nowadays many natural hydrogels such as chitosan, chitin, gelatin, hyaluronic acid, dextran, etc., and synthetic hydrogels such as polyacrylamide, poly(acrylic acid), poly(N-isopropyl acrylamide), and poly(N-vinyl pyrrolidone) have been used extensively for preparing IPNs [1][2][3][4]. IPNs share properties characteristic of each network [5,6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Temperature-sensitive Ternary Interpenetrating Polymeric Networks for Potential Gastrointestinal Drug Release

Ekici¹

2017

J. Drug

View full text Add to dashboard Cite

Interpenetrating polymeric network (IPN) structures have been studied extensively as drug carriers to enhance the required therapeutic effect. In this study, IPNs were prepared in the form of cylindrical by using chitosan known to be biocompatible with the body, poly(N-isopropyl acrylamide) (PNIPAM) which has temperature-sensitive nature, and poly(N-vinyl pyrrolidone) (PVP). N,N'-methylenebisacrylamide (MBA) and glutaraldehyde (GA) were selected as crosslinkers to clamp polymer chains. GA were used in different concentration to control the network porous of the IPNs. Dynamic swelling studies were carried out at pH 1.1 and pH 7.4. Pulsatile swelling studies were performed on all IPN hydrogels to determine to what extent the hydrogels would respond to changes in environmental pH and temperature and how fast that response would be. Amoxicillin was loaded into the hydrogels, and released into buffered solutions as a function of pulsatile changes in temperature and pH. Amoxicillin was loaded into the hydrogels, and released into buffered solutions as a function of pulsatile changes in temperature and pH. The final percentage of amoxicillin released is noted to decrease as the content of GA in the hydrogel increases. Data clearly demonstrate that the use of thermosensitive IPN hydrogels can increase the release of drug molecules from hydrophilic IPNs based on PNIPAM. It can be said from these values that IPNs are intelligent hydrogels and can be thought of as potential devices for pH-and temperaturestimulated sustained delivery of drugs into physiological solutions or for other biomedical applications.

show abstract

Section: Kinetics Swelling Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Temperature-sensitive Ternary Interpenetrating Polymeric Networks for Potential Gastrointestinal Drug Release

Ekici¹

2017

J. Drug

View full text Add to dashboard Cite

show abstract

“…To simultaneously obtain extended and delayed release effects, double-layered microspherical carriers were considered [155][156][157]. Due to the mucoadhesive and penetration enhancement properties of chitosan, its various formulations, including: solutions, suspensions, gels, microemulsions, and powders were reviewed with regard to the nose-to-brain delivery of drugs [158][159][160].…”

Section: Medical Applicationsmentioning

confidence: 99%

Recently developed applications for natural hydrophilic polymers

Halake

Kim

Birajdar

et al. 2016

Journal of Industrial and Engineering Chemistry

View full text Add to dashboard Cite

“…prepared the hydroxyl terminated polybutadiene polyurethane/fluoropolymer IPNs membrane for the pervaporation recovery of butanol. Priya et al . fabricated IPNs using chitosan and egg white crosslinked with polyvinylpyrrolidone (PVP) and poly(ethylene glycol) for drug carrier.…”

Section: Introductionmentioning

confidence: 99%

“…Sun et al 16 prepared the hydroxyl terminated polybutadiene polyurethane/ fluoropolymer IPNs membrane for the pervaporation recovery of butanol. Priya et al 17 fabricated IPNs using chitosan and egg white crosslinked with polyvinylpyrrolidone (PVP) and poly (ethylene glycol) for drug carrier. Cho et al 18 developed a novel composite membranes of IPNs coated on the surfaces of aporous Celgard 2400 support for the application in a non-aqueous redox flow battery.…”

Section: Introductionmentioning

confidence: 99%

PDMS/PVDF microporous membrane with semi‐interpenetrating polymer networks for vacuum membrane distillation

Duan²,

et al. 2017

J of Applied Polymer Sci

View full text Add to dashboard Cite

In this article, using the non‐solvent induced phase separation process, a new microporous membrane with the semi‐interpenetrating polymer network (semi‐IPN) structure was produced. For this membrane, polydimethylsiloxane (PDMS) polymer is crosslinking and poly(vinylidene fluoride) (PVDF) polymer is linear, by changing the mass ratio of PDMS/PVDF, the structure and the performance of the prepared membranes were studied. The membranes were also investigated by attenuated total reflection‐Fourier transform infrared (ATR‐FTIR), scanning electron microscopy–energy‐dispersive X‐ray spectroscopy, X‐ray diffraction, thermogravimetric analysis, and water contact angle, etc. ATR‐FTIR spectroscopy confirmed the formation of semi‐IPN; compared with the PDMS/PVDF polymer without semi‐IPNs structure, the viscosity of the semi‐IPNs structured casting solution increased, membrane mechanical property increased but its hydrophobicity decreased. Using the resulting membranes for the vacuum membrane distillation desalt of the NaCl solution (30 g/L), 99.9% salt rejection and reasonable flux were obtained. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45792.

show abstract

Interpenetrating polymeric networks of chitosan and egg white with dual crosslinking agents polyethylene glycol/polyvinylpyrrolidone as a novel drug carrier

Cited by 21 publications

References 35 publications

Temperature-sensitive Ternary Interpenetrating Polymeric Networks for Potential Gastrointestinal Drug Release

Temperature-sensitive Ternary Interpenetrating Polymeric Networks for Potential Gastrointestinal Drug Release

Recently developed applications for natural hydrophilic polymers

PDMS/PVDF microporous membrane with semi‐interpenetrating polymer networks for vacuum membrane distillation

Contact Info

Product

Resources

About