Interpenetrating polymer network scaffold of sodium hyaluronate and sodium alginate combined with berberine for osteochondral defect regeneration

Chen, Pengfei; Chen, Xia; Mo, Jian; Mei, Sheng; Lin, Xianfeng; Fan, Shunwu

doi:10.1016/j.msec.2018.05.034

Cited by 45 publications

(26 citation statements)

References 28 publications

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“…Most commonly, several of these biomaterials are integrated into a single OCTE strategy, so as to combine their physicochemical properties and attain a more robust construct capable of mimicking both AC and SB layers. Blends of chitosan-alginate [ 95 , 97 , 98 ], chitosan-silk fibroin [ 99 , 100 ], and alginate-hyaluronan [ 101 , 102 , 103 ], for example, have been used for the fabrication of OC scaffolds. In several reports, these organic polymers were further combined with ceramics like β-tricalcium phosphate (β-TCP) [ 97 ], polyphosphate [ 98 ], hydroxyapatite [ 99 , 100 , 102 , 103 , 104 ] or bioglass [ 105 ], thereby resembling the inorganic phase present in SB.…”

Section: Osteochondral Tissue Engineeringmentioning

confidence: 99%

Osteochondral Tissue Engineering: The Potential of Electrospinning and Additive Manufacturing

Gonçalves¹,

Moreira²,

Weber

et al. 2021

Pharmaceutics

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The socioeconomic impact of osteochondral (OC) damage has been increasing steadily over time in the global population, and the promise of tissue engineering in generating biomimetic tissues replicating the physiological OC environment and architecture has been falling short of its projected potential. The most recent advances in OC tissue engineering are summarised in this work, with a focus on electrospun and 3D printed biomaterials combined with stem cells and biochemical stimuli, to identify what is causing this pitfall between the bench and the patients’ bedside. Even though significant progress has been achieved in electrospinning, 3D-(bio)printing, and induced pluripotent stem cell (iPSC) technologies, it is still challenging to artificially emulate the OC interface and achieve complete regeneration of bone and cartilage tissues. Their intricate architecture and the need for tight spatiotemporal control of cellular and biochemical cues hinder the attainment of long-term functional integration of tissue-engineered constructs. Moreover, this complexity and the high variability in experimental conditions used in different studies undermine the scalability and reproducibility of prospective regenerative medicine solutions. It is clear that further development of standardised, integrative, and economically viable methods regarding scaffold production, cell selection, and additional biochemical and biomechanical stimulation is likely to be the key to accelerate the clinical translation and fill the gap in OC treatment.

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Section: Osteochondral Tissue Engineeringmentioning

confidence: 99%

Osteochondral Tissue Engineering: The Potential of Electrospinning and Additive Manufacturing

Gonçalves¹,

Moreira²,

Weber

et al. 2021

Pharmaceutics

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“…Interpenetrating polymer network (IPN) hydrogels were developed aiming to enhance its mechanical properties [50]. IPN, a type of unique mixture of polymers, is composed of two or more cross-linked networks, which are partially intertwined with each other rather than covalently linked [51]. According to recent reports, hydrogels with IPNs tend to exhibit superior mechanical properties compared with those formed by a single type of polymer.…”

Section: The Structure Of Injectable Scaffoldsmentioning

confidence: 99%

“…This IPN hydrogel showed high toughness and increased proliferation, clustering and matrix deposition of encapsulated nucleus pulposus cells when the quantity of the primary network was 4-fold greater than the secondary one. Chen et al [51] investigated the combination of a sodium hyaluronate/sodium alginate (HA/SA)-based scaffold with berberine and found that this system could stimulate the regeneration of cartilage as well as subchondral bone. Furthermore, Guo et al [53] investigated a tri-component IPN hydrogel (consisting of collagen, methacrylate-modified CHS and HA), which can better mimic the natural materials in articular cartilage.…”

Section: The Structure Of Injectable Scaffoldsmentioning

confidence: 99%

Advances of injectable hydrogel-based scaffolds for cartilage regeneration

Chen

et al. 2019

Regenerative Biomaterials

133

102

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Articular cartilage is an important load-bearing tissue distributed on the surface of diarthrodial joints. Due to its avascular, aneural and non-lymphatic features, cartilage has limited self-regenerative properties. To date, the utilization of biomaterials to aid in cartilage regeneration, especially through the use of injectable scaffolds, has attracted considerable attention. Various materials, therapeutics and fabrication approaches have emerged with a focus on manipulating the cartilage microenvironment to induce the formation of cartilaginous structures that have similar properties to the native tissues. In particular, the design and fabrication of injectable hydrogel-based scaffolds have advanced in recent years with the aim of enhancing its therapeutic efficacy and improving its ease of administration. This review summarizes recent progress in these efforts, including the structural improvement of scaffolds, network cross-linking techniques and strategies for controlled release, which present new opportunities for the development of injectable scaffolds for cartilage regeneration.

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“…Alginate hydrogels have also a great potential in cartilage healing when mixed with hyaluronic acid [30,[32][33][34][35]. What deserves special attention is the research results.…”

Section: Articular Cartilagementioning

confidence: 99%

Alginate-Based Hydrogels in Regenerative Medicine

Kaczmarek-Pawelska¹

2020

Alginates - Recent Uses of This Natural Polymer

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This chapter presents the following multipotential applications of alginatebased hydrogels in tissue healing and drug delivery. It contains state of the art and summary of the literature reports, which demonstrate that alginate-based hydrogels have a great potential in tissue healing. Sodium alginate (SA) is mainly used in medical devices for healing of wounds, scars, injuries of bones, regeneration of joint cartilage, and scaffold for cell growth and in drug delivery systems (DDSs). The latest literature describes the effects of laboratory tests and in vivo, which confirm the validity of its use as a biomaterial. Alginate biodegradable scaffolds can be a template that provides a suitable substrate for cellular growth while matching the physiochemical properties of the native extracellular matrix (ECM). Matching scaffold stiffness to the surrounding tissue and optimising its rate of degradation ensure that the infiltrating cells remain viable, maintain their desired phenotype and coordinate their response over the entirety of the wound healing process.

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Interpenetrating polymer network scaffold of sodium hyaluronate and sodium alginate combined with berberine for osteochondral defect regeneration

Cited by 45 publications

References 28 publications

Osteochondral Tissue Engineering: The Potential of Electrospinning and Additive Manufacturing

Osteochondral Tissue Engineering: The Potential of Electrospinning and Additive Manufacturing

Advances of injectable hydrogel-based scaffolds for cartilage regeneration

Alginate-Based Hydrogels in Regenerative Medicine

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