Interobserver Agreement in Grading Activity and Site of Inflammation in Eyes of Patients with Uveitis

Kempen, John H.; Ganesh, Sudha K; Sangwan, Veena; Rathinam, Sivakumar R.

doi:10.1016/j.ajo.2008.06.004

Cited by 114 publications

(93 citation statements)

References 6 publications

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“…However, it is a subjective measure, and the recording of the exact cell grade may only be fair to moderate (17) and requires clinical experience, especially in young children with synechiae and media opacities.…”

Section: Resultsmentioning

confidence: 99%

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Proposed outcome measures for prospective clinical trials in juvenile idiopathic arthritis–associated uveitis: A consensus effort from the multinational interdisciplinary working group for uveitis in childhood

Heiligenhaus

Foeldvari

Edelsten

et al. 2012

Arthritis Care & Research

101

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Objective. To develop a set of core outcome measures for use in randomized controlled trials (RCTs) and longitudinal observational studies in juvenile idiopathic arthritis (JIA)-associated uveitis. Methods. The literature relating to outcome measures used in studies of uveitis in childhood and adolescence was reviewed. A set of core outcomes and domains was established using the Delphi process. This was reviewed by a representative multinational interdisciplinary working group. Nominal group technique consensus was reached on face and content validity of the range and content of the domains. The outcomes and the appropriate instruments for uveitis trials were adapted to the age ranges of patients with JIA-associated uveitis. Results. Consensus was reached that data should be reported at defined time points in longitudinal studies with patients stratified by prognostic markers. Visual acuity testing should be age appropriate. The severity of uveitis (measured as anterior chamber cell grade) and duration of active inflammation should be documented. Visually significant structural complications should be recorded and quantified with standard measures. The responses to treatment and corticosteroidsparing effects of treatment should be documented. Patient-reported disease activity and age-specific uveitis-related quality of life should be reported using appropriate questionnaires. Conclusion. The proposed outcome measures in JIA-associated uveitis should aid in the standardization and comparison of future RCTs of the treatment regimens for this disease. The proposed outcome measures will be verified in a prospective validation study.

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Section: Resultsmentioning

confidence: 99%

“…Laser flare photometry is an objective technique (17,20), but it is time consuming, expensive, and not feasible as a measure in many patients with JIA-associated uveitis. The participants therefore considered that photometry should not be a necessary instrument, but remain a research tool for prospective RCTs.…”

Section: Resultsmentioning

confidence: 99%

Proposed outcome measures for prospective clinical trials in juvenile idiopathic arthritis–associated uveitis: A consensus effort from the multinational interdisciplinary working group for uveitis in childhood

Heiligenhaus

Foeldvari

Edelsten

et al. 2012

Arthritis Care & Research

101

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“…cell is challenging even among uveitis specialists. 2 As the gold standard measurement has variability, it can make comparisons to a new grading method such as OCT more challenging, but it also highlights the need for a more standardized, and automated, grading system.…”

Section: Discussionmentioning

confidence: 99%

High-Speed Optical Coherence Tomography as a Reliable Adjuvant Tool to Grade Ocular Anterior Chamber Inflammation

Igbre¹,

Rico

Garg

2014

Retina

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“…The standard method for grading the breakdown of the BAB is the so-called AC flare at the slit lamp (Hogan et al 1959;Jabs et al 2005;Ladas et al 2005). As a result of the semiquantitative nature of the proposed criteria for grading AC cells and flare, they are only moderately reproducible (Kempen et al 2008). A better system for grading AC flare is laser flare (LF) photometry (Ladas et al 2005).…”

mentioning

confidence: 99%

Elevated laser flare values correlate with complicated course of anterior uveitis in patients with juvenile idiopathic arthritis

Tappeiner

Heinz

Roesel

et al. 2011

Acta Ophthalmologica

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. Purpose: To evaluate the prognostic value of anterior chamber (AC) laser flare (LF) in uveitis associated with juvenile idiopathic arthritis (JIA). Methods: Monocentre, retrospective study of 150 JIA children (girls n = 107, 71.3%) with unilateral or bilateral chronic anterior uveitis (statistical analysis of one eye per patient). LF values (KOWA FM‐500), visual acuity, intraocular pressure, glaucoma treatment and uveitis complications were investigated longitudinally. Results: Patients were followed up for a mean of 8.7 months (range 1–36). High LF values correlated with poor visual acuity (p < 0.0001). Patients with low LF values (LF ≤ 20 photon units per millisecond) less often required glaucoma medication (p = 0.0005) or surgery (p = 0.01) and showed a lower prevalence of cataract, band keratopathy, posterior synechiae, epiretinal membrane, optic disc oedema and glaucoma/ocular hypertension (p < 0.05, each). Baseline LF > 20 photon units per millisecond was a better prognosticator for the development of subsequent complications than baseline AC cells (p = 0.04). Conclusions: High LF values in patients with JIA uveitis are associated with poor vision and a higher prevalence of uveitis complications.

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Interobserver Agreement in Grading Activity and Site of Inflammation in Eyes of Patients with Uveitis

Cited by 114 publications

References 6 publications

Proposed outcome measures for prospective clinical trials in juvenile idiopathic arthritis–associated uveitis: A consensus effort from the multinational interdisciplinary working group for uveitis in childhood

Proposed outcome measures for prospective clinical trials in juvenile idiopathic arthritis–associated uveitis: A consensus effort from the multinational interdisciplinary working group for uveitis in childhood

High-Speed Optical Coherence Tomography as a Reliable Adjuvant Tool to Grade Ocular Anterior Chamber Inflammation

Elevated laser flare values correlate with complicated course of anterior uveitis in patients with juvenile idiopathic arthritis

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