High-Speed Optical Coherence Tomography as a Reliable Adjuvant Tool to Grade Ocular Anterior Chamber Inflammation

Comparison of time-domain, spectral-domain and swept-source OCT in evaluating aqueous cells in vitro

“…Many kinds of commercial OCTs were available in clinic to evaluate the anterior segment of eyeball (Agarwal et al, 2009;Igbre et al, 2014;Kumar et al, 2014;Li et al, 2013;Sharma et al, 2015). We only chose three commercial OCTs in this study, which represent three kinds of OCTs.…”

“…Cirrus HD Fourier-domain OCT (model 4000, Carl Zeiss Meditec AG) (Kumar et al, 2014), another SD-OCT, has also been used to evaluate the aqueous cells in vivo before. Previous studies showed that both TD-OCT and SD-OCT were reliable in assessing aqueous cells in patients with uveitis (Agarwal et al, 2009;Igbre et al, 2014;Li et al, 2013;Sharma et al, 2015) or post intraocular surgery (Kumar et al, 2014). Casia SS-1000 OCT is a swept-source anterior segment OCT, it was widely used in anterior segment imaging due to its high scan speed and large scan field (Baskaran et al, 2013).…”

“…It was the first generation of OCT used to evaluate the aqueous cells. Several studies showed that it can quantify the aqueous cells both in vivo and in vitro (Agarwal et al, 2009;Igbre et al, 2014;Li et al, 2013). RTVue XR Avanti OCT is a SD-OCT with the highest A-scan speed among three OCTs we used which has never been employed in discerning aqueous cells.…”

“…These researches showed anterior segment OCT (AS-OCT) can detect anterior chamber inflammatory cells in patients with uveitis (Agarwal et al, 2009;Igbre et al, 2014;Li et al, 2013;Sharma et al, 2015) or post ocular operation (Kumar et al, 2014). In addition, AS-OCT has also been used to quantitatively assess the anterior chamber cells in a small rodent model of uveitis (Pepple et al, 2016).…”

“…There are several ways to quantify the aqueous cells, including slit-lamp biomicroscopy (Jabs et al, 2005), ultrasound biomicroscopy (UBM) (Peizeng et al, 2009), laser flare photometry (Ladas et al, 2005) and optical coherence tomography (OCT) (Agarwal et al, 2009;Igbre et al, 2014;Kumar et al, 2014;Li et al, 2013;Sharma et al, 2015).…”