Small and medium-sized enterprises (SMEs) represent the dominant form of business organization in the economic system globally and play important roles in the economic development and increased competitiveness of the economy in the European Union (EU). The presented article analyzes the state and existing specific problems that have been observed in the existing practices related to the functioning and maintenance of the specialized information and communication systems and e-business technologies of the studied group of Bulgarian small and medium-sized industrial enterprises. The basic instrument for collecting the empirical data in the present study was a questionnaire survey conducted at 70 Bulgarian enterprises. How to implement appropriate technological solutions through which to overcome existing problems and to provide strategic advantages for the surveyed organizations in conducting e-business? Аs a result of identified shortcomings, obstacles and necessities, the main purpose of this study is to develop and present an integrated model for introduction of technological solutions aimed to improve the efficiency of automated and virtualised business activities in Internet, extranet and intranet environments. The developed model is based on specific information and communication technologies and contemporary good practices and aims to improve the e-business system in the long term, which in turn will lead to the increased sustainability and competitiveness of organizations in the economic market.