International variation in disease burden of rotavirus gastroenteritis in children with community- and nosocomially acquired infection

Frühwirth, Martin; Heininger, Ulrich; Ehlken, B; Petersen, Gundula; Laubereau, Birgit; Moll-Schuler, Ingrid; Mutz, I; Förster, Johannes

doi:10.1097/00006454-200108000-00013

Cited by 88 publications

(80 citation statements)

References 29 publications

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“…The incidence of rotavirus diarrhoea requiring hospital admission in children presenting at the emergency department was 40%, which is similar to that reported in other European countries [11,18,20,21], but lower than the 70% rate found in Canada [24].…”

Section: Discussionsupporting

confidence: 81%

Rotavirus and not age determines gastroenteritis severity in children: a hospital-based study

et al. 2006

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Section: Discussionsupporting

confidence: 81%

Rotavirus and not age determines gastroenteritis severity in children: a hospital-based study

et al. 2006

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“…Unexpectedly, G9-RoV was the second most common G-type found, at a prevalence as high as 5%. This genotype has not been previously detected in Germany [Fruhwirth et al, 2001;Ehlken et al, 2002], but recent reports from developing Unicomb et al, 1999] and developed countries [Ramachandran et al, 1998;Cubitt et al, 2000;Griffin et al, 2000;Oka et al, 2000] indicate a global emergence of this Gtype viewed over years as unusual . Of particular importance, G9 RoV has been associated with serious neonatal diarrhea outbreaks; it has been discussed that neonates may lack maternal protective antibodies to a genotype their mothers have not been exposed to and are, therefore, especially vulnerable [Cicirello et al, 1994;Widdowson et al, 2000].…”

Section: Discussionmentioning

confidence: 81%

“…Concerning the epidemiology of gastroenteritis viruses among German children, the existing data include three viruses at most [Putzker et al, 2000;Schulz et al, 2000;Fruhwirth et al, 2001;Ehlken et al, 2002]. To date, no information on the importance of NV in a pediatric German population has been available.…”

Section: Discussionmentioning

confidence: 99%

Viral agents of acute gastroenteritis in German children: Prevalence and molecular diversity

Gaedicke

Schreier

2003

Journal of Medical Virology

200

121

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Acute gastroenteritis is a major source of morbidity and mortality among young children in developed and developing countries. Enteropathogenic viruses are regarded as particularly relevant causative agents. Between February 2001 and January 2002, fecal specimens were obtained from German children admitted to hospital with acute gastroenteritis and examined for rotaviruses, Noroviruses, enteric adenoviruses, and astroviruses using (RT-)PCR methods. Of the 59% (129/217) samples positive for > or =1 viral agent, 79% (102/129) carried rotavirus, whereas Norovirus was detected in 35% (45/129), enteric adenovirus in 14% (18/129), and astrovirus in 4% (5/129). Thirty-eight specimens contained at least two enteropathogenic viruses, with the majority of coinfections attributable to rotavirus/Norovirus dual infections. Sequence analysis revealed a cocirculation of G1, G3, G4, and G9 type rotavirus with G1 being the most common and G9 the second most common rotavirus G-type. Emergence of G9 rotaviruses in Germany may have implications for future vaccine development. A variety of Norovirus genotypes, most belonging to GGII, were found. Apart from subgenus F, adenovirus related genetically to subgenera A-C were detected. All astroviruses belonged to genotype 1. This is the first study concerning German children admitted to hospital that assesses the relative importance of these viruses by nested (RT-) PCR methods.

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“…The associated costs of any disease are very dependent on the seriousness of the illness, but also on the level of patient's dependence. It is important to underline that the main burden of hospitalization due to RV gastroenteritis is with children under 2 years of age [11,12,20,24].…”

Section: Discussionmentioning

confidence: 99%

“…This was a 13-month-old boy with autoimmune hemolytic anemia and [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] and 519 (96.3%) patients had a score ≥11, generally considered as "severe disease" (Fig. 2).…”

Section: Clinical Characteristicsmentioning

confidence: 99%

A 4-year study on clinical characteristics of children hospitalized with rotavirus gastroenteritis

et al. 2009

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Rotavirus (RV) is a frequent cause of severe gastroenteritis (GE) in children. With the licensure of new RV vaccines, data on the burden of disease are important regarding immunization strategies. We reviewed the medical records of children hospitalized with RV infection in our institution between July 2002 and March 2006. Relevant data were extracted in a standardized fashion from records of hospitalized children with a positive RV antigen test in a stool sample. Severity of disease was graded by the 20-point Vesikari score. Population data were obtained from the Federal Office of Statistics. Six hundred eighty-six RVGE were identified and records of 608 hospitalizations (in 607 children) were available. In 539 (89%) cases, RVGE was the primary reason for hospitalization and 69 (11%) were nosocomial infections; yearly peaks occurred between February and May. Cumulative incidence of RVGE was 26.7/1,000 children <3 years of age. Median age of 539 children (55.6% male) with primary RVGE was 1.4 years and median stay in the hospital for both community acquired and nosocomial RVGE was 4 days (interquartile range 3-5). Thirtypercent and 94% of RV hospitalizations were in children <1 and <3 years of age, respectively. Mean Vesikari score was 15 (range 6-20; 96% >11). Intravenous fluids were administered in 378 (70%) patients, 130 (24%) patients were rehydrated via nasogastral tube, and 31 (5.7%) received rehydration by mouth. RVGE causes a substantial burden in children with an estimated risk for hospitalization due to RVGE of one in 37 children <3 years of age.

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International variation in disease burden of rotavirus gastroenteritis in children with community- and nosocomially acquired infection

Abstract: The cumulative experience from three European countries suggest that rotavirus is an important cause of diarrhea in Central Europe, but significant local differences clearly demonstrate the need for obtaining national data as a reliable basis for control and prevention of the disease.

Cited by 88 publications

References 29 publications

Rotavirus and not age determines gastroenteritis severity in children: a hospital-based study

Rotavirus and not age determines gastroenteritis severity in children: a hospital-based study

Viral agents of acute gastroenteritis in German children: Prevalence and molecular diversity

A 4-year study on clinical characteristics of children hospitalized with rotavirus gastroenteritis

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