International validation of a health‐related quality of life questionnaire in patients with erosive gastro‐oesophageal reflux disease

Abstract

SUMMARY BackgroundAlthough erosive gastro-oesophageal reflux disease (GERD) is a highly prevalent condition, there is no specific, valid, reliable and sensitive questionnaire that allows evaluating treatment-induced changes in health-related quality of life (HRQoL).

Quality of life scales for patients with gastroesophageal reflux disease: A literature review

“…To calculate the total score of the GERDyzer, the first factor is weighted by 1.0 and the second is weighted by 0.5. Holtmann et al [19] reported that they were able to obtain a consistently high Cronbach's a coefficient of 0.95, a high test-retest reliability demonstrated by an ICC of 0.91 and a responsiveness of 1.38. In Germany, Monnikes et al [20] utilized the GERDyzer to confirm the efficiency of Pantoprazole in relieving upper and lower GI symptoms in patients with erosive esophagitis.…”

“…The GERDyzer is a self-administered questionnaire primarily designed to evaluate the impact of erosive GERD on QOL and to assist medical staff in determining an optimal therapeutic strategy [19]. The GERDyzer consists of 10 dimensions that can be clustered into two factors based on factor analysis.…”

Development of the Northwestern Esophageal Quality of Life Scale: A Hybrid Measure for Use Across Esophageal Conditions

“…Existing measures of HRQOL for GERD, dysphagia, achalasia, EoE, and Barrett’s esophagus were reviewed for content by three study investigators (TT, LK, and JP): Gastrointestinal Quality of Life Index (18), Quality of Life in Reflux and Dyspepsia Patients (19), GERD Analyzer (20), GERD Assessment Scales (21), Nepean Dyspepsia Index (22), MD Anderson Dysphagia Inventory (23), Laryngopharyngeal Reflux HRQOL scale (24), Reflux-QUAL (25), Eosinophilic Esophagitis QOL-A (7), Achalasia QOL (13), and the GERDQ (26). Relevant themes related to HRQOL were identified, and items from each questionnaire grouped by theme.…”

Factors influencing treatment outcome in patients with gastroesophageal reflux disease: outcome of a prospective pragmatic trial in Asian patients

“…Finally, the GERDyzer™ is a questionnaire that evaluates the impact of GERD on a patient’s quality of life across 10 dimensions: general well-being, pain/discomfort, physical health, energy, daily activities, leisure activities, social life, diet/eating/drinking habits, mood and sleep [22]. Each dimension is assessed using a 100 mm visual analogue scale ranging from ‘not at all’ to ‘very much’, with the exception of ‘general well-being’, which is assessed from ‘excellent to ‘unbearably bad’.…”