This study aims to explain the impact of personality dispositions and social orientations on the relocation mobility readiness. This study was conducted in an Indonesian public audit institution. This institution applies a policy to relocate its employees periodically to any of 34 provinces in Indonesia. The samples were 374 non-structural employees. The survey was conducted to collect data about the relocation mobility readiness, the personality dispositions (neuroticism, openness to experience, and uncertainty tolerance) and the social orientations (social norm, individualism orientation, collectivism orientation). The convenience sampling method was used in this study, while the hierarchical regression was used as an analysis method. This study indicates that personality dispositions and social orientations significantly influence the relocation mobility readiness. The higher the value of the uncertainty tolerance and social norm, the higher the employees' readiness to be relocated. The higher the vertical collectivism, the lower the employees' readiness to be relocated. Therefore, the institution should provide its employees and their families with supporting programs so that they are ready to be transferred to other areas in Indonesia.