2014
DOI: 10.1177/0192623314560031
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International Harmonization of Nomenclature and Diagnostic Criteria (INHAND)

Abstract: The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice proposal (INHAND) has been operational since 2005. A Global Editorial Steering Committee manages the overall objectives of the project, and the development of harmonized terminology for each organ system is the responsibility of the Organ Working Groups, drawing upon experts from North America, Europe, and Japan. Great progress has been made with 9 systems published to date-respiratory, hepatobiliary, urinary, … Show more

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Cited by 30 publications
(9 citation statements)
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“…Slides were stained with hematoxylin and eosin and interpreted by two separate, contracted, board-certified veterinary pathologists in a blinded fashion for evidence of hyperplasia and neoplasia, inflammation, lymphoid tissue response, and foreign materials by light microscopy. Diagnostic criteria for hyperplastic and neoplastic findings were according to go RENI (http://www.goreni.org/), the standard reference for nomenclature and diagnostic criteria in toxicologic pathology and at the same time the Internet discussion platform for the global initiative “INHAND”—the International Harmonization of Nomenclature and Diagnostic criteria (Keenan et al 2015; Renne et al 2009). If abnormal changes were found, severity was scored using the following scale: 1 = minimal, 2 = mild, 3 = moderate, 4 = marked.…”
Section: Methodsmentioning
confidence: 99%
“…Slides were stained with hematoxylin and eosin and interpreted by two separate, contracted, board-certified veterinary pathologists in a blinded fashion for evidence of hyperplasia and neoplasia, inflammation, lymphoid tissue response, and foreign materials by light microscopy. Diagnostic criteria for hyperplastic and neoplastic findings were according to go RENI (http://www.goreni.org/), the standard reference for nomenclature and diagnostic criteria in toxicologic pathology and at the same time the Internet discussion platform for the global initiative “INHAND”—the International Harmonization of Nomenclature and Diagnostic criteria (Keenan et al 2015; Renne et al 2009). If abnormal changes were found, severity was scored using the following scale: 1 = minimal, 2 = mild, 3 = moderate, 4 = marked.…”
Section: Methodsmentioning
confidence: 99%
“…for severe or marked changes (more than 50%), following guidelines from the INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) [7].…”
Section: Histopathologic Studymentioning
confidence: 99%
“…Slides were stained with hematoxylin and eosin and interpreted by a board-certified veterinary pathologist in a blinded fashion for evidence of hyperplasia and neoplasia, inflammation, lymphoid tissue response, and foreign materials by light microscopy. Diagnostic criteria for hyperplastic and neoplastic findings were according to go RENI (http://www.goreni.org/), the standard reference for nomenclature and diagnostic criteria in toxicologic pathology and “INHAND,” the International Harmonization of Nomenclature and Diagnostic criteria [27, 28]. If abnormal changes were found, severity was scored by the pathologist using the following scale: 1 = minimal, 2 = mild, 3 = moderate, 4 = marked.…”
Section: Methodsmentioning
confidence: 99%