International Harmonization of Nomenclature and Diagnostic Criteria (INHAND)

Keenan, Charlotte M.; Baker, Julia F. M.; Bradley, Alys; Goodman, Dawn G.; Harada, Takanori; Herbert, Ronald A.; Kaufmann, Wolfgang; Kellner, Rupert; Mahler, Beth; Meseck, Emily K.; Nolte, Thomas; Rittinghausen, Susanne; Vahle, John L.; Yoshizawa, Katsuhiko

doi:10.1177/0192623314560031

Cited by 30 publications

(9 citation statements)

References 2 publications

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“…Slides were stained with hematoxylin and eosin and interpreted by two separate, contracted, board-certified veterinary pathologists in a blinded fashion for evidence of hyperplasia and neoplasia, inflammation, lymphoid tissue response, and foreign materials by light microscopy. Diagnostic criteria for hyperplastic and neoplastic findings were according to go RENI (http://www.goreni.org/), the standard reference for nomenclature and diagnostic criteria in toxicologic pathology and at the same time the Internet discussion platform for the global initiative “INHAND”—the International Harmonization of Nomenclature and Diagnostic criteria (Keenan et al 2015; Renne et al 2009). If abnormal changes were found, severity was scored using the following scale: 1 = minimal, 2 = mild, 3 = moderate, 4 = marked.…”

Section: Methodsmentioning

confidence: 99%

Inhalation of gas metal arc–stainless steel welding fume promotes lung tumorigenesis in A/J mice

et al. 2017

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Epidemiologic studies suggest an increased risk of lung cancer with exposure to welding fumes, but controlled animal studies are needed to support this association. Oropharyngeal aspiration of collected "aged" gas metal arc-stainless steel (GMA-SS) welding fume has been shown by our laboratory to promote lung tumor formation in vivo using a two-stage initiation-promotion model. Our objective in this study was to determine whether inhalation of freshly generated GMA-SS welding fume also acts as a lung tumor promoter in lung tumor-susceptible mice. Male A/J mice received intraperitoneal (IP) injections of corn oil or the chemical initiator 3-methylcholanthrene (MCA; 10 µg/g) and 1 week later were exposed by whole-body inhalation to air or GMA-SS welding aerosols for 4 h/d × 4 d/w × 9 w at a target concentration of 40 mg/m. Lung nodules were enumerated at 30 weeks post-initiation. GMA-SS fume significantly promoted lung tumor multiplicity in A/J mice initiated with MCA (16.11 ± 1.18) compared to MCA/air-exposed mice (7.93 ± 0.82). Histopathological analysis found that the increased number of lung nodules in the MCA/GMA-SS group were hyperplasias and adenomas, which was consistent with developing lung tumorigenesis. Metal deposition analysis in the lung revealed a lower deposited dose, approximately fivefold compared to our previous aspiration study, still elicited a significant lung tumorigenic response. In conclusion, this study demonstrates that inhaling GMA-SS welding fume promotes lung tumorigenesis in vivo which is consistent with the epidemiologic studies that show welders may be at an increased risk for lung cancer.

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Section: Methodsmentioning

confidence: 99%

Inhalation of gas metal arc–stainless steel welding fume promotes lung tumorigenesis in A/J mice

et al. 2017

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“…for severe or marked changes (more than 50%), following guidelines from the INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) [7].…”

Section: Histopathologic Studymentioning

confidence: 99%

Histopathological study of the kidney after administration of methanolic extract of roots of <i>Leptadenia hastata</i> in the Albino Wistar rat

Diallo¹,

Bah²,

Dial³

et al. 2020

OJPathology

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Introduction: The roots of Leptadenia hastata (L. hastata) are remedies from the Senegalese pharmacopoeia and are as widely used as the leaves. However, few researchers have devoted themselves to their toxicity, unlike the leaves. However, in the traditional pharmacopoeia, the indications for use are very different. The aim of our study was to study the effect of the administration of methanolic extracts of roots of L. hastata on renal tissue, using an animal model. Materials and Methods: A cohort of 18 rats was studied with a random distribution of the animals in 3 groups (n = 6). The first group was the control group. The treated groups (Group II and III) received the methanolic

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“…Slides were stained with hematoxylin and eosin and interpreted by a board-certified veterinary pathologist in a blinded fashion for evidence of hyperplasia and neoplasia, inflammation, lymphoid tissue response, and foreign materials by light microscopy. Diagnostic criteria for hyperplastic and neoplastic findings were according to go RENI (http://www.goreni.org/), the standard reference for nomenclature and diagnostic criteria in toxicologic pathology and “INHAND,” the International Harmonization of Nomenclature and Diagnostic criteria [27, 28]. If abnormal changes were found, severity was scored by the pathologist using the following scale: 1 = minimal, 2 = mild, 3 = moderate, 4 = marked.…”

Section: Methodsmentioning

confidence: 99%

Pulmonary toxicity and lung tumorigenic potential of surrogate metal oxides in gas metal arc welding–stainless steel fume: Iron as a primary mediator versus chromium and nickel

et al. 2018

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In 2017, the International Agency for Research on Cancer classified welding fumes as “carcinogenic to humans” (Group 1). Both mild steel (MS) welding, where fumes lack carcinogenic chromium and nickel, and stainless steel (SS) increase lung cancer risk in welders; therefore, further research to better understand the toxicity of the individual metals is needed. The objectives were to (1) compare the pulmonary toxicity of chromium (as Cr(III) oxide [Cr2O3] and Cr (VI) calcium chromate [CaCrO4]), nickel [II] oxide (NiO), iron [III] oxide (Fe2O3), and gas metal arc welding-SS (GMAW-SS) fume; and (2) determine if these metal oxides can promote lung tumors. Lung tumor susceptible A/J mice (male, 4–5 weeks old) were exposed by oropharyngeal aspiration to vehicle, GMAW-SS fume (1.7 mg), or a low or high dose of surrogate metal oxides based on the respective weight percent of each metal in the fume: Cr2O3 + CaCrO4 (366 + 5 μg and 731 + 11 μg), NiO (141 and 281 μg), or Fe2O3 (1 and 2 mg). Bronchoalveolar lavage, histopathology, and lung/liver qPCR were done at 1, 7, 28, and 84 days post-aspiration. In a two-stage lung carcinogenesis model, mice were initiated with 3-methylcholanthrene (10 μg/g; intraperitoneal; 1x) or corn oil then exposed to metal oxides or vehicle (1 x/week for 5 weeks) by oropharyngeal aspiration. Lung tumors were counted at 30 weeks post-initiation. Results indicate the inflammatory potential of the metal oxides was Fe2O3 > Cr2O3 + CaCrO4 > NiO. Overall, the pneumotoxic effects were negligible for NiO, acute but not persistent for Cr2O3 + CaCrO4, and persistent for the Fe2O3 exposures. Fe2O3, but not Cr2O3 + CaCrO4 or NiO significantly promoted lung tumors. These results provide experimental evidence that Fe2O3 is an important mediator of welding fume toxicity and support epidemiological findings and the IARC classification.

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International Harmonization of Nomenclature and Diagnostic Criteria (INHAND)

Cited by 30 publications

References 2 publications

Inhalation of gas metal arc–stainless steel welding fume promotes lung tumorigenesis in A/J mice

Inhalation of gas metal arc–stainless steel welding fume promotes lung tumorigenesis in A/J mice

Histopathological study of the kidney after administration of methanolic extract of roots of <i>Leptadenia hastata</i> in the Albino Wistar rat

Pulmonary toxicity and lung tumorigenic potential of surrogate metal oxides in gas metal arc welding–stainless steel fume: Iron as a primary mediator versus chromium and nickel

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International Harmonization of Nomenclature and Diagnostic Criteria (INHAND)

Cited by 30 publications

References 2 publications

Inhalation of gas metal arc–stainless steel welding fume promotes lung tumorigenesis in A/J mice

Inhalation of gas metal arc–stainless steel welding fume promotes lung tumorigenesis in A/J mice

Histopathological study of the kidney after administration of methanolic extract of roots of &lt;i&gt;Leptadenia hastata&lt;/i&gt; in the Albino Wistar rat

Pulmonary toxicity and lung tumorigenic potential of surrogate metal oxides in gas metal arc welding–stainless steel fume: Iron as a primary mediator versus chromium and nickel

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Histopathological study of the kidney after administration of methanolic extract of roots of <i>Leptadenia hastata</i> in the Albino Wistar rat