Internal metal(loid)s are potentially involved in the association between ambient fine particulate matter and blood pressure: A repeated-measurement study in north China

Lan, Xi; Liu, Yingying; Qi, Liqun; Wang, Bin; Xue, Tao; Chen, Junxi; Jiangtulu, Bahabaike; Ge, Shufang; Wang, Xuepeng; Gao, Miaomiao; Yu, Yanxin; Xu, Ying; Zhao, Xueyan; Li, Zhiwen

doi:10.1016/j.chemosphere.2020.129146

Cited by 6 publications

(1 citation statement)

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“…Molybdenum (Mo) is an essential trace element for the normal human physiology and functions as a cofactor for several enzymes in metabolism, including xanthine oxidoreductase (XOR), aldehyde oxidase (AO), sulfite oxidase (SO), nitrite reductases, and mitochondrial amidoxime reducing component (mARC) [13][14][15][16][17]. Among general adults, legumes, grain products, nuts, and dark-leafy vegetables, which showed beneficial effects for human metabolic health, are the major food sources of molybdenum [17].…”

Section: Introductionmentioning

confidence: 99%

Inverse Association of Plasma Molybdenum with Metabolic Syndrome in a Chinese Adult Population: A Case-Control Study

Huang

Luo

et al. 2021

Nutrients

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Molybdenum has been found to be associated with metabolic disorders. However, the relationship between molybdenum and metabolic syndrome (MetS) is still unclear. A large case-control study was conducted in a Chinese population from the baseline of Ezhou-Shenzhen cohort. A total of 5356 subjects were included with 2678 MetS and 2678 controls matched by sex and age (±2 years). Medians (IQRs) of plasma molybdenum concentrations were 1.24 μg/L for MetS cases and 1.46 μg/L for controls. After adjustment for multiple covariates, the odds ratio (OR) and 95% confidence intervals (CIs) for MetS were 1.00 (reference), 0.71 (0.59–0.84), 0.56 (0.46–0.68), and 0.47 (0.39–0.58) across quartiles of plasma molybdenum, and per SD increment of log-transformed molybdenum was associated with a 23% lower risk of MetS. In the spline analysis, the risk of MetS and its components decreased steeply with increasing molybdenum and followed by a plateau when the cutoff point was observed around 2.0 μg/L. The dose-dependent relationship of molybdenum with MetS remained consistent when considering other essential elements in the Bayesian kernel machine regression (BKMR) model. In our study, higher plasma molybdenum was significantly associated with a lower risk of MetS, as well as its components, in a dose-response manner.

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