Internal mammary artery graft function is not affected in hypertensive patients on therapy

Deja, Marek; Gołba, Krzysztof S.; Woś, Stanisław; Mrozek, Roman; Bachowski, Ryszard; Biernat, Jolanta

doi:10.1016/s0967-2109(97)00055-0

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…This lack of effect in IMA has been demonstrated before,29 however other authors have noted decreased endothelial responses in the presence of hypertension 30. There are few available vascular reactivity data to which we can compare our SV results, with many authors31–35 concentrating upon particular facets of SV response utilising specific chemicals.…”

Section: Discussionsupporting

confidence: 68%

Role of Gender, Smoking Profile, Hypertension, and Diabetes on Saphenous Vein and Internal Mammary Artery Endothelial Relaxation in Patients with Coronary Artery Bypass Grafting

Muir

McKeown

Bayraktutan

2010

Oxidative Medicine and Cellular Longevity

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The aim of this study was to investigate if there was a link between the relaxant responses in saphenous vein (SV) and internal mammary artery (IMA) segments obtained from patients undergoing coronary artery bypass grafting and the patients' cardiovascular risk factors. Endothelium-(in)dependent relaxations were assessed by isometric tension studies. Endothelium-dependent relaxant responses were greater in IMA than SV and gender, smoking profile and history of hypertension but not diabetes appeared to have an influence on these responses. Endothelium-dependent relaxant responses in both IMA and SV were greater in males than females and relaxant responses in IMA segments were attenuated in smokers, whereas the opposite effect was noted in SV segments. Endothelium-dependent relaxant responses in SV were lower in patients with hypertension. Endothelium-independent relaxant responses were greater in IMA than SV. Endothelium-independent responses were greater in male patients' SV segments, but gender played no role in IMA segments. Diabetes had no effect on endothelium-independent responses in IMA, but SV segments from diabetic patients had greater responses. Neither conduit's endothelium-independent response was affected by hypertensive status. The relationship between risk factor status and endothelial responses is multifactorial, with gender, hypertension, diabetes and smoking status all contributing.

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Section: Discussionsupporting

confidence: 68%

Role of Gender, Smoking Profile, Hypertension, and Diabetes on Saphenous Vein and Internal Mammary Artery Endothelial Relaxation in Patients with Coronary Artery Bypass Grafting

Muir

McKeown

Bayraktutan

2010

Oxidative Medicine and Cellular Longevity

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“…Moreover, the hyperpolarization to bradykinin and associated NOindependent relaxation has been shown to be enhanced by perindoprilat in human coronary arteries [29]. We have shown previously that endothelium-dependent relaxation to acetylcholine in human ITA segments is stronger in ACE inhibitor-treated hypertensive patients in comparison with normotensive controls receiving no ACE inhibitor [10]. We had ascribed that finding at the time to ACE inhibitors possibly increasing available NO amount.…”

Section: Discussionmentioning

confidence: 88%

“…Its physiological role may be involved more in relaxation responses of resistance rather than conduit arteries [9]. We have shown previously that effective treatment of arterial hypertension with angiotensin-converting enzyme inhibitors enhances endothelium-dependent relaxation to acetylcholine in segments of human internal thoracic artery (ITA) above this observed in segments obtained from nonhypertensive patients not receiving ACE inhibitors (ACE-I) [10]. The present study was designed to assess the endothelium-dependent responses mediated by neither NO nor prostacyclin in human internal thoracic artery segments.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin-converting enzyme inhibitors reveal non-NO-, non-prostacycline-mediated endothelium-dependent relaxation in internal thoracic artery of hypertensive patients

Deja

Gołba

Widenka

et al. 2005

International Journal of Cardiology

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Intraoperative and laboratory evaluation of skeletonized versus pedicled internal thoracic artery

Deja¹,

Woś²,

Gołba³

et al. 1999

The Annals of Thoracic Surgery

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Internal mammary artery graft function is not affected in hypertensive patients on therapy

Cited by 3 publications

References 36 publications

Role of Gender, Smoking Profile, Hypertension, and Diabetes on Saphenous Vein and Internal Mammary Artery Endothelial Relaxation in Patients with Coronary Artery Bypass Grafting

Role of Gender, Smoking Profile, Hypertension, and Diabetes on Saphenous Vein and Internal Mammary Artery Endothelial Relaxation in Patients with Coronary Artery Bypass Grafting

Angiotensin-converting enzyme inhibitors reveal non-NO-, non-prostacycline-mediated endothelium-dependent relaxation in internal thoracic artery of hypertensive patients

Intraoperative and laboratory evaluation of skeletonized versus pedicled internal thoracic artery

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