Internal desynchronization in a model of night-work by forced activity in rats

Salgado‐Delgado, Roberto; Ángeles-Castellanos, Manuel; Buijs, M.R.; Escobar, Carolina

doi:10.1016/j.neuroscience.2008.03.066

Cited by 144 publications

(165 citation statements)

References 51 publications

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“…Experimental studies in humans and animals have shown that this metabolic mismatch can disrupt blood glucose and triglyceride rhythmicity, [27] dampen liver transcriptional rhythms, [28] and ultimately lead to compromised pancreatic beta cell function, decreased energy expenditure, leptin resistance, and diabetes. [28] , [29] , [30] These mechanisms might underlie the epidemiological associations between BMI and diabetes and shiftwork that are identified in this study and others, and the effects of shiftwork on circadian rhythms in metabolic function require further investigation.…”

Section: Discussionmentioning

confidence: 67%

Adverse metabolic and mental health outcomes associated with shiftwork in a population-based study of 277,168 workers in UK biobank

et al. 2017

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Section: Discussionmentioning

confidence: 67%

Adverse metabolic and mental health outcomes associated with shiftwork in a population-based study of 277,168 workers in UK biobank

et al. 2017

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“…SalgadoDelgado et al (37) developed an animal model of night work in which the light -dark cycle remained stable and where rats were required to be active in a rotating wheel for 8 h daily during their sleeping phase. This group was compared with rats that worked in the wheel during their activity phase and with undisturbed rats.…”

Section: Shift Work and Circadian Cycle Disruptionmentioning

confidence: 99%

Obesity and shift work: chronobiological aspects

et al. 2010

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The present review has the objective of summarising chronobiological aspects of shift work and obesity. There was a systematic search in PubMed databases, using the following descriptors: shift work; obesity; biological clock. Shift work is extremely frequent in several services and industries, in order to systematise the needs for flexibility of the workforce, necessary to optimise productivity and business competitiveness. In developing countries, this population represents a considerable contingent workforce. Recently, studies showed that overweight and obesity are more prevalent in shift workers than day workers. In addition, the literature shows that shift workers seem to gain weight more often than those workers submitted to a usual work day. In conclusion, there is considerable epidemiological evidence that shift work is associated with increased risk for obesity, diabetes and CVD, perhaps as a result of physiological maladaptation to chronically sleeping and eating at abnormal circadian times. The impact of shift work on metabolism supports a possible pathway to the development of obesity and its co-morbities. The present review demonstrated the adverse cardiometabolic implications of circadian misalignment, as occurs chronically with shift workers.

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“…Cyclic, clock-like expression of "clock genes," in central and peripheral tissue neurons, liver, and fat cells, with expression in rhythmic patterns synced to external environments, impacts food intake, energy expenditure, and sleep (117). In animal models of activity during normal sleep times or of fragmented sleep periods, disruption of this mechanism is associated with energy metabolism malfunction, development of obesity, and disrupted glucose utilization (118)(119)(120)(121). Shift work and circadian disruption has also been associated with changes in gastrointestinal and metabolic processes such as fat absorption and metabolism, melatonin-related lipid metabolism, enteric autonomic function, and altered insulin signaling in human subcutaneous fat (121)(122)(123)(124)(125).…”

Section: Example 23mentioning

confidence: 99%

Conceptual heuristic models of the interrelationships between obesity and the occupational environment

Pandalai¹,

Schulte²,

Miller³

2013

Scand J Work Environ Health

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Pandalai SP, Schulte PA, Miller DB. Conceptual heuristic models of the interrelationships between obesity and the occupational environment. Scand J Work Environ Health. 2013;39(3):221-232. doi:10.5271/sjweh.3363 Objective Research and interventions targeting the relationship between work, its attendant occupational hazards, and obesity are evolving but merit further consideration in the public health arena. In this discussion paper, conceptual heuristic models are described examining the role of obesity as both a risk factor and health outcome in the occupational setting.Methods PubMed was searched using specific criteria from 2000 and onwards for evidence to support conceptual models in which obesity serves as a risk factor for occupational disease or an outcome of occupational exposures. Nine models are presented: four where obesity is a risk factor and five where it is an adverse effect.Results A broad range of work-related health effects are associated with obesity including musculoskeletal disorders, asthma, liver disease, and cardiovascular disease, among others. Obesity can be associated with occupational hazards such as shift work, sedentary work, job stress, and exposure to some chemicals. Conclusion Identification of combinations of risk factors pertinent to obesity in the occupational environmentwill provide important guidance for research and prevention.Key terms cardiovascular disease; diet; endocrine disruptor; intervention study; metabolism; musculoskeletal disease; occupational health; physical activity; risk assessment.1 National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA.Correspondence to: Sudha P Pandalai, MD, PhD, National Institute for Occupational Safety and Health Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, Obesity is increasing worldwide with the 2009-2010 prevalence among US adults surpassing one-third (1, 2). Obesity is associated with genetic, behavioral, occupational, and environmental factors (3-5) and has significant economic impact (6). It is also associated with various health problems including musculoskeletal disorders (MSD), asthma, liver disease, and cardiovascular disease (CVD) (7-10). Moreover, neurohormonal and endocrine pathway disruption has been associated with obesity (11,12). Work factors, including sedentary work and taskrelated biomechanics, have been reported as risks for obesity (13)(14)(15). Variables such as irregular work hours/ sleep schedules, job stress, workplace absenteeism, and reduced productivity also contribute (16)(17)(18)(19).Although the related literature is growing, obesity in the occupational environment requires more study, for example, regarding low-wage workers and genes or other factors (20,21). Body mass index (BMI), a measure of obesity, varies by population, race, gender, and socioeconomic class (22)(23)(24). Genetics may account for ≥40% of the variation in BMI (25), but such estimates can depend on the variability of environ...

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Internal desynchronization in a model of night-work by forced activity in rats

Cited by 144 publications

References 51 publications

Adverse metabolic and mental health outcomes associated with shiftwork in a population-based study of 277,168 workers in UK biobank

Adverse metabolic and mental health outcomes associated with shiftwork in a population-based study of 277,168 workers in UK biobank

Obesity and shift work: chronobiological aspects

Conceptual heuristic models of the interrelationships between obesity and the occupational environment

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