Internal consistency and test–retest reliability of the P3 event‐related potential (ERP) elicited by alcoholic and non‐alcoholic beverage pictures

Abstract

There has long been interest among addiction researchers in the ability of event-related potentials (ERPs) to index individual differences in addiction liability factors (Kamarajan & Porjesz, 2015;Kinreich et al., 2021; Rangaswamy & Porjesz, 2014). One of the most common ERP-based measures of addiction risk is P3 amplitude reduction (P3-AR) observed during various cognitive tasks, particularly the "rotated heads" mental rotation oddball task (Begleiter et al., 1984;Iacono et al., 2002). Since its discovery in the context of alcoholism risk (see early review in Porjesz & Begleiter, 1981), a large body of evidence has established that individual differences in the P3-AR reflect a genetically based, heritable endophenotypic vulnerability for externalizing behavior and disorders, including

Retrospective self-reports of sensitivity to the effects of alcohol: Trait-like stability and concomitant changes with alcohol involvement.

“…Sociodemographic information for the sample is reported in Table 1. Additional findings from this study have been reported elsewhere (Cofresí, Kohen, et al, 2022; Cofresí, Piasecki, & Bartholow, 2022; Cofresí, Piasecki, Hajcak, & Bartholow, 2022; Kohen et al, 2023; Waddell et al, 2023).…”

Acute sensitization of the P3 event-related potential response to beverage images and the risk for alcohol use disorder

“…2 and S2 ). Although the functional (i.e., psychological) significance of this within-session trajectory for ACR is unclear, it does provide an explanation for the limited psychometric reliability of commonly used across-trial average ACR scores [ 16 ]. Furthermore, it suggests that researchers interested in using such P3/LPP difference scores as a measure of individual differences in incentive salience-based risk for problematic alcohol/drug use should consider estimating within-session trajectories in order to be able to extract the model-estimated difference score at the start of the session (i.e., before habituation/extinction effects and/or before ceiling effects on sensitization).…”

Predictive utility of the P3 event‐related potential (ERP) response to alcohol cues for ecologically assessed alcohol craving and use

“…20 Furthermore, the P3/LPP is enhanced for alcohol/drug relative to control cues among alcohol/drug users relative to non-users 21,22 and among users with higher relative to lower alcohol use disorder (AUD) risk profiles. 8,[23][24][25] The P3/LPP elicited by alcohol cues (i.e., AlcP3) has shown strong test-retest reliability over 10 months, 26 supporting its use as an index of individual differences in IS attribution.…”