Internal and surface structure characterization of cellulose triacetate hollow-fiber dialysis membranes

Yamazaki, Katsumi; Matsuda, Masato; Yamamoto, Kenichiro; Yakushiji, Taiji; Sakai, Kiyotaka

doi:10.1016/j.memsci.2010.11.008

Cited by 26 publications

(19 citation statements)

References 21 publications

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“…Cellulose triacetate hemodialysis membranes have traditionally had a homogeneous pore structure in which the pore size is essentially uniform throughout the thickness of the membrane [8,9]. Although thin homogeneous membranes can provide very high levels of urea clearance, they typically have lower rates of middle molecule clearance due to the high resistance to mass transfer throughout the membrane [10].…”

Section: Introductionmentioning

confidence: 99%

Transport Characteristics of Asymmetric Cellulose Triacetate Hemodialysis Membranes

et al. 2017

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Aims: The objective of this study was to compare the transport characteristics of highly asymmetric cellulose triacetate (ATA™) membranes with that of both symmetric cellulose triacetate and asymmetric polysulfone membranes. Methods: Data were obtained for solute clearance and sieving coefficients of vitamin B₁₂ and a range of polydisperse dextrans using ATA™ SOLACEA-25H and Optiflux F250NR polysulfone dialyzers. Results for these, and the CT190 symmetric cellulose triacetate dialyzer, were analyzed using available membrane transport models. Results: The ATA™ had the largest solute clearance, although the homogeneous CT190 dialyzer had the highest sieving coefficients. These differences were a direct result of the differences in the underlying membrane morphology, with the asymmetric ATA™ membrane providing much higher diffusive transport rates (and thus higher solute clearance). Conclusions: These results demonstrate the importance of membrane morphology on dialyzer transport and provide important insights into the effective clinical performance observed with the highly asymmetric ATA™ dialyzers.

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Section: Introductionmentioning

confidence: 99%

Transport Characteristics of Asymmetric Cellulose Triacetate Hemodialysis Membranes

et al. 2017

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“…Atomic force microscopy (AFM) has been used in medical devices and in the analysis of surface properties of industrial materials since the late 1990s [5,6,[13][14][15][16]. AFM does not require pretreatment such as metal coating and allows three-dimensional observation thereby achieving resolution at nanometer scale and providing information on the porosity of the membrane surface and the power spectrum density.…”

Section: Introductionmentioning

confidence: 99%

“…Hayama et al [5] conducted intensive studies on the observation of dialysis membranes using AFM, and demonstrated for the rst time clear AFM images of the surface pores of a hollow ber dialysis membrane [5,13]. They concluded from the results that by nanomicroscopic method, AFM allows observation and quantitative analysis of the surface shape and the pore structure of a hollow ber hemodialysis membrane in wet and dry states, but it was impossible to observe three-dimensional pores with depth by AFM [5,6]. To observe soft materials such as hemodialysis membranes by AFM, scanning of the probe frequently lead to dragging or deformation of the samples, impeding high resolution.…”

Section: Introductionmentioning

confidence: 99%

“…The tortuous capillary pore model was also proposed to clarify the relationship of the pore structure of semipermeable membrane with pure water permeability and sieving coef cient, and analysis was performed [5][6][7][8][9][10][11]. Especially, the pore diameter and diameter distribution of the innermost surface greatly affect the pure water permeability and sieving coef cient of solutes.…”

Section: Introductionmentioning

confidence: 99%

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Observation and Proposed Measurements of Three-dimensional Tortuous Capillary Pores with Depth for Hollow Fiber Hemoconcentrator Membrane Using Dynamic Force Microscopy

Fukuda

Saomoto

Shimizu

et al. 2019

ABE

Self Cite

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A hemoconcentrator is installed as a part of cardiopulmonary bypass to concentrate the blood by removing excess water and unnecessary electrolytes from the blood diluted with myocardial protection uid. The hemoconcentrator must remove water from diluted blood ef ciently and quickly and remove proin ammatory cytokines and other unwanted molecules, without losing useful proteins such as albumin. Especially, the pore diameter and diameter distribution of the innermost surface greatly affect the pure water permeability and sieving coef cient of the solutes. In this study, the pore structure of the inner surface of the membrane was observed, and pore measurement of hollow ber hemoconcentrator membranes was attempted using a scanning probe microscope (SPM). The samples studied were commercially available hemoconcentrator membranes PUREMA A and B (JMS Co. Ltd., Japan) having asymmetric structures. A SPM was used using the dynamic force microscopy (DFM), cyclic contact mode. The deep and tortuous pore structure on the inner surface of the hemoconcentrator membrane was observed for the rst time using DFM. The pores had an elliptical shape, elongated in the longitudinal direction. When the elliptical area on the inner surface of the hemoconcentrator membrane was larger, pure water permeability was higher, showing a correlation between the elliptical area and membrane functions. The mean major pore diameters and minor pore diameters as well as the equivalent pore diameter calculated from the tortuous capillary pore model were consistent. Using DFM, the three-dimensional tortuous capillary pores at the inner surface of a hollow ber hemoconcentrator membrane could be studied, and pore diameter and distribution could be measured by image analysis. The results were supported by the tortuous capillary pore model. In the future, we need to clearly show the further superior innovations or creative/ ingenious techniques related to this study. Further the state of new ndings which contribute to development of a new hemoconcentrator and other semipermeable membranes will help to increase the value of this paper. This study is one of the key studies to achieve the targeted function for the transport phenomena through semipermeable membranes including hemoconcentrator.

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“…The concentrate flows through the interior of the fibers and the pure solvent is recovered in the shell [5]. Hemodialysis allows the removal of waste products (uremic toxins) and excess fluids from the blood (retentate phase) of end-stage renal disease (ESRD) patients to dialysate phase [6], to replace renal function which leads to prevent the accumulation of uremic toxins in the patients' bodies [7]. With regard to artificial kidney, simultaneous dialysis and ultrafiltration (SDF) is of significant interest [8].…”

Section: Introductionmentioning

confidence: 99%

Performance analysis of mass transfer of hollow fiber hemodialyser with ultrafiltration and varied dialysate concentration

Kamali

Hormozi

Karimi

2014

2nd Middle East Conference on Biomedical Engineering

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A mathematical model of mass transfer in hollow fiber hemodialyser with simultaneous dialysis and ultrafiltration is developed numerically in this study. The influence of dialysate phase flow rate, flow rate configuration (co-and counter-current) and ultrafiltration velocity are investigated. The numerical simulations show that the introduction of ultrafiltration effects in a dialysis system can improve separation as compared with the pure dialysis without ultrafiltration.

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Internal and surface structure characterization of cellulose triacetate hollow-fiber dialysis membranes

Cited by 26 publications

References 21 publications

Transport Characteristics of Asymmetric Cellulose Triacetate Hemodialysis Membranes

Transport Characteristics of Asymmetric Cellulose Triacetate Hemodialysis Membranes

Observation and Proposed Measurements of Three-dimensional Tortuous Capillary Pores with Depth for Hollow Fiber Hemoconcentrator Membrane Using Dynamic Force Microscopy

Performance analysis of mass transfer of hollow fiber hemodialyser with ultrafiltration and varied dialysate concentration

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