Intermolecular exciton–exciton annihilation in phospholipid vesicles doped with [Ru(bpy)2dppz]2+

Cadena, Alejandro De la; Pascher, Torbjörn; Davydova, Dar’ya; Akimov, D. A.; Herrmann, F. P.; Presselt, Martin; Wächtler, Maria; Dietzek, Benjamin

doi:10.1016/j.cplett.2015.11.024

Cited by 14 publications

(13 citation statements)

References 42 publications

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“…Panel c displays the data for the 1:1 ratio, which reveals a partial ground state recovery within the first 2 ns after photoexcitation. This spectral evolution can be accounted for by two distinct kinetic components (characterized τ 1 = 4 ps and τ 2 = 250 ps), which is in line with the results published in literature 33 36 . However, this situation changes qualitatively when studying the Ru-complexes in the presence of DNA base pairs in a concentration ratio of 1:4 (see Fig.…”

Section: Resultssupporting

confidence: 90%

“…The characteristic spectral signatures of the latter state are reflected in the long-lived transient absorption spectra in Fig. 3 panel d 33 36 51 .…”

Section: Resultsmentioning

confidence: 95%

“…the overall concentration and the pump power used, are far off from values that have been previously reported to lead to such inter-chromophore quenching. Therefore, we consider the contributions from inter-chromophore effects on the concentration dependent transient absorption kinetics of compound 1 in the lysate negligible 36 .…”

Section: Resultsmentioning

confidence: 99%

“…The intercalation was proven by photophysical and NMR studies 25 26 27 28 and crystal structures of Ru(II)-dppz-DNA adducts have been reported quite recently 29 . The photophysical properties of the archetypical molecular light switch compound 1 and related complexes have widely been studied in (aqueous) solutions in absence and presence of DNA 23 26 30 31 32 33 34 and embedded into phospholipid vesicles 35 36 . Other studies based on luminescence imaging and flow cytometry have focused on the cellular uptake into cells, their intra cellular localization and their cytotoxicity of Ru(II)-polypyridine complexes 16 18 37 38 39 40 41 .…”

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confidence: 99%

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Ultrafast in cellulo photoinduced dynamics processes of the paradigm molecular light switch [Ru(bpy)2dppz]2+

Cadena

Davydova

Tolstik

et al. 2016

Sci Rep

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An in cellulo study of the ultrafast excited state processes in the paradigm molecular light switch [Ru(bpy)2dppz]2+ by localized pump-probe spectroscopy is reported for the first time. The localization of [Ru(bpy)2dppz]2+ in HepG2 cells is verified by emission microscopy and the characteristic photoinduced picosecond dynamics of the molecular light switch is observed in cellulo. The observation of the typical phosphorescence stemming from a 3MLCT state suggests that the [Ru(bpy)2dppz]2+ complex intercalates with the DNA in the nucleus. The results presented for this benchmark coordination compound reveal the necessity to study the photoinduced processes in coordination compounds for intracellular use, e.g. as sensors or as photodrugs, in the actual biological target environment in order to derive a detailed molecular mechanistic understanding of the excited-state properties of the systems in the actual biological target environment.

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Section: Resultssupporting

confidence: 90%

“…The characteristic spectral signatures of the latter state are reflected in the long-lived transient absorption spectra in Fig. 3 panel d 33 36 51 .…”

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Ultrafast in cellulo photoinduced dynamics processes of the paradigm molecular light switch [Ru(bpy)2dppz]2+

Cadena

Davydova

Tolstik

et al. 2016

Sci Rep

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“…Since Barton et al first reported the observation of a molecular light switch, the interactions between these two ruthenium complexes with a DNA helix have been intensively explored by the researchers. Several studies have focused on the mechanism of the molecular light switch [12,19,20,21,22,23,24]. The studies of the interactions between [Ru(bpy) 2 dppz] 2+ /[Ru(phen) 2 dppz] 2+ and the different forms of DNA strands have been intensively studied by scientists for a better understanding of the photoluminescence of these two intercalated ruthenium compounds upon binding with DNA helix.…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in the Interactions of Classic Intercalated Ruthenium Compounds: [Ru(bpy)2dppz]2+ and [Ru(phen)2dppz]2+ with a DNA Molecule

et al. 2019

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[Ru(bpy)2dppz]2+ and [Ru(phen)2dppz]2+ as the light switches of the deoxyribose nucleic acid (DNA) molecule have attracted much attention and have become a powerful tool for exploring the structure of the DNA helix. Their interactions have been intensively studied because of the excellent photophysical and photochemical properties of ruthenium compounds. In this perspective, this review describes the recent developments in the interactions of these two classic intercalated compounds with a DNA helix. The mechanism of the molecular light switch effect and the selectivity of these two compounds to different forms of a DNA helix has been discussed. In addition, the specific binding modes between them have been discussed in detail, for a better understanding the mechanism of the light switch and the luminescence difference. Finally, recent studies of single molecule force spectroscopy have also been included so as to precisely interpret the kinetics, equilibrium constants, and the energy landscape during the process of the dynamic assembly of ligands into a single DNA helix.

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Mimicking Photosystem I with a Transmembrane Light Harvester and Energy Transfer‐Induced Photoreduction in Phospholipid Bilayers

Pannwitz

Saaring

Beztsinna

et al. 2020

Chemistry A European J

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Photosystem I (PS I) is a transmembrane protein that assembles perpendicular to the membrane, and performs light harvesting, energy transfer, and electron transfer to a final, water‐soluble electron acceptor. We present here a supramolecular model of it formed by a bicationic oligofluorene 12+ bound to the bisanionic photoredox catalyst eosin Y (EY2−) in phospholipid bilayers. According to confocal microscopy, molecular modeling, and time dependent density functional theory calculations, 12+ prefers to align perpendicularly to the lipid bilayer. In presence of EY2−, a strong complex is formed (Ka=2.1±0.1×106 m−1), which upon excitation of 12+ leads to efficient energy transfer to EY2−. Follow‐up electron transfer from the excited state of EY2− to the water‐soluble electron donor EDTA was shown via UV–Vis absorption spectroscopy. Overall, controlled self‐assembly and photochemistry within the membrane provides an unprecedented yet simple synthetic functional mimic of PS I.

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Intermolecular exciton–exciton annihilation in phospholipid vesicles doped with [Ru(bpy)2dppz]2+

Cited by 14 publications

References 42 publications

Ultrafast in cellulo photoinduced dynamics processes of the paradigm molecular light switch [Ru(bpy)2dppz]2+

Ultrafast in cellulo photoinduced dynamics processes of the paradigm molecular light switch [Ru(bpy)2dppz]2+

Recent Developments in the Interactions of Classic Intercalated Ruthenium Compounds: [Ru(bpy)2dppz]2+ and [Ru(phen)2dppz]2+ with a DNA Molecule

Mimicking Photosystem I with a Transmembrane Light Harvester and Energy Transfer‐Induced Photoreduction in Phospholipid Bilayers

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