Intermittent Theta Burst Stimulation vs. High-Frequency Repetitive Transcranial Magnetic Stimulation in the Treatment of Methamphetamine Patients

Liu, Qingming; Sun, Huimeng; Hu, Yitian; Wang, Qiongyao; Zhao, Zhiyong; Dong, Da; Shen, Ying

doi:10.3389/fpsyt.2022.842947

Cited by 4 publications

(6 citation statements)

References 34 publications

(38 reference statements)

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“…TMS stimulation on DLPFC also an FDA-approved treatment for depression (FDA approval K061053). Therefore, like tDCS, DLPFC is also the most commonly targeted stimulation area to modulate METH addiction ( showed that iTBS, which is a more time-efficient protocol, had similar effects to those of rTMS at 10 Hz (145). Besides the studies discussed in Table 5, some ongoing protocols have been proposed to investigate the effects of TMS treatment on METH addiction.…”

Section: Tms For Methamphetamine Addictionmentioning

confidence: 99%

“…Only one study uses EEG signals together with VAS scores to assess the effects (144). Some studies use images (125,141,143,145), some use videos (135) and still others use VR as the cues (144). One study asks the participants to actively interact with the tools used for METH consumption (142).…”

Section: Tms For Methamphetamine Addictionmentioning

confidence: 99%

“…The most common assessment is self-rating questionnaires regarding depression, anxiety, and withdrawal symptom. Results have indicated that the VAS, depression, anxiety, and withdrawal symptoms all decrease after TMS treatment (145). iTBS has become a more popular treatment approach because it takes less time to achieve the same therapeutic effect as rTMS (145).…”

Section: Tms For Methamphetamine Addictionmentioning

confidence: 99%

“…Results have indicated that the VAS, depression, anxiety, and withdrawal symptoms all decrease after TMS treatment (145). iTBS has become a more popular treatment approach because it takes less time to achieve the same therapeutic effect as rTMS (145). However, comparing the longterm effects of various protocols is challenging because the results reported after TMS treatments are not over the same time frame.…”

Section: Tms For Methamphetamine Addictionmentioning

confidence: 99%

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Challenges and future trends in wearable closed-loop neuromodulation to efficiently treat methamphetamine addiction

Chen

Yang

et al. 2023

Front. Psychiatry

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Achieving abstinence from drugs is a long journey and can be particularly challenging in the case of methamphetamine, which has a higher relapse rate than other drugs. Therefore, real-time monitoring of patients’ physiological conditions before and when cravings arise to reduce the chance of relapse might help to improve clinical outcomes. Conventional treatments, such as behavior therapy and peer support, often cannot provide timely intervention, reducing the efficiency of these therapies. To more effectively treat methamphetamine addiction in real-time, we propose an intelligent closed-loop transcranial magnetic stimulation (TMS) neuromodulation system based on multimodal electroencephalogram–functional near-infrared spectroscopy (EEG-fNIRS) measurements. This review summarizes the essential modules required for a wearable system to treat addiction efficiently. First, the advantages of neuroimaging over conventional techniques such as analysis of sweat, saliva, or urine for addiction detection are discussed. The knowledge to implement wearable, compact, and user-friendly closed-loop systems with EEG and fNIRS are reviewed. The features of EEG and fNIRS signals in patients with methamphetamine use disorder are summarized. EEG biomarkers are categorized into frequency and time domain and topography-related parameters, whereas for fNIRS, hemoglobin concentration variation and functional connectivity of cortices are described. Following this, the applications of two commonly used neuromodulation technologies, transcranial direct current stimulation and TMS, in patients with methamphetamine use disorder are introduced. The challenges of implementing intelligent closed-loop TMS modulation based on multimodal EEG-fNIRS are summarized, followed by a discussion of potential research directions and the promising future of this approach, including potential applications to other substance use disorders.

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Section: Tms For Methamphetamine Addictionmentioning

confidence: 99%

Section: Tms For Methamphetamine Addictionmentioning

confidence: 99%

Section: Tms For Methamphetamine Addictionmentioning

confidence: 99%

Section: Tms For Methamphetamine Addictionmentioning

confidence: 99%

See 2 more Smart Citations

Challenges and future trends in wearable closed-loop neuromodulation to efficiently treat methamphetamine addiction

Chen

Yang

et al. 2023

Front. Psychiatry

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“…We applied 10 Hz TMS trains for 5 s (50 pulses). These 5 s trains were used instead of 4 s trains following prior studies in an attempt to enhance the effects [46][47][48][49]. Each TMS train was followed by a first single pulse probe at 500 ms (early probe) and a second single pulse probe at 2000 ms (late probe), as defined in the previous section and depicted in Fig 1B . Probe TMS pulses were always 'active', regardless of whether they were preceded by an active or sham TMS train.…”

Section: Transcranial Magnetic Stimulationmentioning

confidence: 99%

Neural effects of TMS trains on the human prefrontal cortex

Ross

Cline

Sarkar

et al. 2023

Preprint

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Despite adoption of repetitive TMS (rTMS) for the treatment of neuropsychiatric disorders, a lack of understanding of its neural effects limits our ability to monitor, personalize, and adapt treatments. Here we address the methodological limitations in capturing the neural response to a single TMS train, the fundamental building block of treatment. We developed methods to measure these effects noninvasively and evaluated the acute neural response to single and sequential TMS trains. In 16 healthy adults, we applied 10 Hz trains to the dorsolateral prefrontal cortex (dlPFC) in a randomized, sham-controlled, event-related design and assessed changes to the TMS-evoked potential (TEP), a measure of local cortical excitability. We hypothesized that single TMS trains would induce changes in the local TEP amplitude that would accumulate across trains, but we found no evidence in support of this hypothesis. However, exploratory analyses demonstrated modulations non-locally and in phase and source space. Single and sequential TMS trains may not be sufficient to modulate the local TEP amplitude, but induce acute neural changes measured in alternative ways. This work should be contextualized as methods development for the monitoring of transient neural changes during rTMS and contributes to a growing understanding of the neural effects of rTMS.

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Neural effects of TMS trains on the human prefrontal cortex

Ross,

Cline,

Sarkar

et al. 2023

Sci Rep

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How does a train of TMS pulses modify neural activity in humans? Despite adoption of repetitive TMS (rTMS) for the treatment of neuropsychiatric disorders, we still do not understand how rTMS changes the human brain. This limited understanding stems in part from a lack of methods for noninvasively measuring the neural effects of a single TMS train—a fundamental building block of treatment—as well as the cumulative effects of consecutive TMS trains. Gaining this understanding would provide foundational knowledge to guide the next generation of treatments. Here, to overcome this limitation, we developed methods to noninvasively measure causal and acute changes in cortical excitability and evaluated this neural response to single and sequential TMS trains. In 16 healthy adults, standard 10 Hz trains were applied to the dorsolateral prefrontal cortex in a randomized, sham-controlled, event-related design and changes were assessed based on the TMS-evoked potential (TEP), a measure of cortical excitability. We hypothesized that single TMS trains would induce changes in the local TEP amplitude and that those changes would accumulate across sequential trains, but primary analyses did not indicate evidence in support of either of these hypotheses. Exploratory analyses demonstrated non-local neural changes in sensor and source space and local neural changes in phase and source space. Together these results suggest that single and sequential TMS trains may not be sufficient to modulate local cortical excitability indexed by typical TEP amplitude metrics but may cause neural changes that can be detected outside the stimulation area or using phase or source space metrics. This work should be contextualized as methods development for the monitoring of transient noninvasive neural changes during rTMS and contributes to a growing understanding of the neural effects of rTMS.

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Intermittent Theta Burst Stimulation vs. High-Frequency Repetitive Transcranial Magnetic Stimulation in the Treatment of Methamphetamine Patients

Cited by 4 publications

References 34 publications

Challenges and future trends in wearable closed-loop neuromodulation to efficiently treat methamphetamine addiction

Challenges and future trends in wearable closed-loop neuromodulation to efficiently treat methamphetamine addiction

Neural effects of TMS trains on the human prefrontal cortex

Neural effects of TMS trains on the human prefrontal cortex

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