Intermittent pneumatic compression in chronic venous insufficiency favorably affects fibrinolytic potential and platelet activation

Kessler, Craig M.; Hirsch, Denise R.; Jacobs, Helena M.; MacDougall, Regina C.; Goldhaber, Samuel Z.

doi:10.1097/00001721-199606000-00002

Cited by 51 publications

(47 citation statements)

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“…9 IPC devices ("pneumoboots") provide intermittent inflation of air-filled cuffs, prevent venous stasis in the legs, and compress the veins more forcefully than GCS; they also stimulate the endogenous fibrinolytic system. 10 Their main drawback is lack of use due to poor patient compliance, especially after transfer out of the intensive care unit.…”

Section: Strategies To Prevent Pe After Cabgmentioning

confidence: 99%

Pulmonary Embolism After Coronary Artery Bypass Grafting

Goldhaber

Schoepf

2004

Circulation

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Section: Strategies To Prevent Pe After Cabgmentioning

confidence: 99%

Pulmonary Embolism After Coronary Artery Bypass Grafting

Goldhaber

Schoepf

2004

Circulation

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“…Since it was first introduced into clinical use in 1972 (Hills et al, 1972), IPC has been widely used clinically as an effective means of preventing the development of DVT and PE (Clagett and Reisch, 1988;Woolson and Watt, 1991;Pidala et al, 1992;Woolson, 1996) and has been shown to reduce the incidence of DVT from 29-53% in patients treated with pharmacological agents to 17% in patients treated with IPC (Westrich et al, 2000). Studies have suggested that this mechanical method effectively reduces the incidence of DVT without side effects by preventing stasis in the venous system through an increase in venous blood flow (Janssen et al, 1993;Killewich et al, 1995;Malone et al, 1999) and by elevating fibrinolytic activity Kessler et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Intermittent pneumatic compression regulates expression of nitric oxide synthases in skeletal muscles

Xiangling

et al. 2006

Journal of Biomechanics

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“…Studies have suggested that this mechanical method effectively reduces the incidence of deep vein thrombosis without side effects by preventing stasis in the venous system through an increase in venous blood flow (13,17) and by elevating fibrinolytic activity (16,28).…”

mentioning

confidence: 99%

Intermittent pneumatic compression of legs increases microcirculation in distant skeletal muscle

Liu

Chen

Seaber

et al. 1999

Journal Orthopaedic Research

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Intermittent pneumatic compression has been established as a method of clinically preventing deep vein thrombosis, but the mechanism has not been documented. This study observed the effects of intermittent pneumatic compression of legs on the microcirculation of distant skeletal muscle. The cremaster muscles of 80 male rats were exposed, a specially designed intermittent pneumatic-compression device was applied to both legs for 60 minutes, and the microcirculation of the muscles was assessed by measurement of the vessel diameter in three categories (10-20, 21-40, and 41-70 microm) for 120 minutes. The results showed significant vasodilation in arterial and venous vessels during the application of intermittent pneumatic compression, which disappeared after termination of the compression. The vasodilation reached a maximum 30 minutes after initiation of the compression and could be completely blocked by an inhibitor of nitric oxide synthase, NG-monomethyl-L-arginine (10 micromol/min). A 120-minute infusion of NG-monomethyl-L-arginine, beginning coincident with 60 minutes of intermittent pneumatic compression, resulted in a significant decrease in arterial diameter that remained at almost the same level after termination of the compression. The magnitude of the decrease in diameter in the group treated with intermittent pneumatic compression and NG-monomethyl-L-arginine was comparable with that in the group treated with NG-monomethyl-L-arginine alone. The results imply that the production of nitric oxide is involved in the positive influence of intermittent pneumatic compression on circulation. It is postulated that the rapid increase in venous velocity induced by intermittent pneumatic compression produces strong shear stress on the vascular endothelium, which stimulates an increased release of nitric oxide and thereby causes systemic vasodilation.

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Intermittent pneumatic compression in chronic venous insufficiency favorably affects fibrinolytic potential and platelet activation

Cited by 51 publications

References 0 publications

Pulmonary Embolism After Coronary Artery Bypass Grafting

Pulmonary Embolism After Coronary Artery Bypass Grafting

Intermittent pneumatic compression regulates expression of nitric oxide synthases in skeletal muscles

Intermittent pneumatic compression of legs increases microcirculation in distant skeletal muscle

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