Intermittent phototherapy versus continuous phototherapy for neonatal jaundice

Gottimukkala, Sasi Bhushan; Lobo, Lisha; Gautham, Kanekal Suresh; Bolisetty, Srinivas; Fiander, Michelle; Schindler, Tim

doi:10.1002/14651858.cd008168.pub2

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…A 2023 systematic review, which included 12 randomised controlled trials, compared intermittent phototherapy with continuous phototherapy by any method and at any dose and duration. 20 It identified little or no difference between the two interventions in the rate of decline of bilirubin in term jaundiced infants. Continuous phototherapy was more effective in preterm infants.…”

Section: Phototherapymentioning

confidence: 99%

Innovative approaches to neonatal jaundice diagnosis and management in low-resourced settings

Saloojee

2024

South African Family Practice

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Persistent challenges in addressing severe neonatal hyperbilirubinaemia in resource-constrained settings have led to ongoing and often unacceptable rates of morbidity, disability and mortality. These challenges stem from limitations such as inadequate, inefficient or financially inaccessible diagnostic and therapeutic options. However, over the past decade, noteworthy innovations have emerged to address some of these hurdles, and these innovations are increasingly poised for broader implementation. This review provides a concise summary of these novel, economically viable diagnostic solutions, encompassing point-of-care assays and smartphone applications, as well as treatment modalities, notably more effective phototherapy and filtered sunlight. These advancements hold promise and have the potential to meaningfully reduce the burden of neonatal hyperbilirubinaemia, signifying a promising shift in the landscape of neonatal healthcare.

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Section: Phototherapymentioning

confidence: 99%

Innovative approaches to neonatal jaundice diagnosis and management in low-resourced settings

Saloojee

2024

South African Family Practice

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“…Excessive UCB induces oxidative stress damage, impacting mitochondrial oxidative metabolism, suppressing cellular oxygen utilization, leading to cellular energy depletion and triggering intracellular calcium overload, which is the main cause of neuron damage [ 3 ]. Phototherapy stands as a widely accepted and effective primary treatment for neonatal jaundice [ 5 ]. Although phototherapy and exchange transfusion have therapeutic effects, kernicterus still causes disability and even death [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Repetitive Transcranial Magnetic Stimulation on Pallidum GABAergic Neurons and Motor Function in Rat Models of Kernicterus

Wang,

Jia,

Zhou

et al. 2023

Brain Sciences

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Kernicterus is a serious complication of hyperbilirubinemia, caused by neuronal injury due to excessive unconjugated bilirubin (UCB) in specific brain areas. This injury induced by this accumulation in the globus pallidus can induce severe motor dysfunction. Repetitive transcranial magnetic stimulation (rTMS) has shown neuroprotective effects in various neurological diseases. This study aimed to investigate the effects of rTMS on pallidal nerve damage and motor dysfunction in a rat model of kernicterus. Rats were divided into a sham group (n = 16), a model group (bilirubin with sham rTMS; n = 16) and an rTMS group (bilirubin with rTMS; n = 16). High-frequency rTMS (10 Hz) was applied starting from 24 h postmodeling for 7 days. The rotarod test, western blotting and immunohistochemical staining were performed to measure motor function and protein expression levels. The rTMS mitigated the negative effects of UCB on the general health of kernicterus-model rats and improved their growth and development. Furthermore, the rTMS alleviated UCB-induced motor dysfunction and increased the expression of GABAergic neuronal marker GAD67 in the globus pallidus. Notably, it also inhibited apoptosis-related protein caspase-3 activation. In conclusion, rTMS could alleviate motor dysfunction by inhibiting apoptosis and increasing globus pallidus GAD67 in kernicterus rat models, indicating that it may be a promising treatment for kernicterus.

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