Intermittent neural synchronization in Parkinson’s disease

Rubchinsky, Leonid L.; Park, Choongseok; Worth, Robert M.

doi:10.1007/s11071-011-0223-z

Cited by 77 publications

(38 citation statements)

References 95 publications

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“…Lowering this parameter would thus correspond to stronger striatal inhibition (GPe neuron will exhibit less of its own dynamics and will be more easily controlled by excitatory inputs from STN). This increase of striatal inhibition is expected in a Parkinsonian state, because striatopallidal synapses are presynaptically suppressed by dopamine, which degenerates in Parkinson's disease (see discussion in Terman et al, 2002; Park et al, 2011; Rubchinsky et al, 2012). As I app increases, the dynamics of the STN-GPe network becomes less synchronized (Terman et al, 2002; Park et al, 2011).…”

Section: Resultsmentioning

confidence: 99%

“…As g syn increases (in the network without input), the dynamics of STN-GPe circuits transits from less to more synchronized network dynamics (Park et al, 2011). These synapses may be suppressed by dopamine (see discussion in Terman et al, 2002; Park et al, 2011; Rubchinsky et al, 2012), so that moving from a healthy to a Parkinsonian state would correspond to increasing g syn .…”

Section: Resultsmentioning

confidence: 99%

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Synchronized Beta-Band Oscillations in a Model of the Globus Pallidus-Subthalamic Nucleus Network under External Input

Ahn

Zauber

Worth

et al. 2016

Front. Comput. Neurosci.

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Hypokinetic symptoms of Parkinson's disease are usually associated with excessively strong oscillations and synchrony in the beta frequency band. The origin of this synchronized oscillatory dynamics is being debated. Cortical circuits may be a critical source of excessive beta in Parkinson's disease. However, subthalamo-pallidal circuits were also suggested to be a substantial component in generation and/or maintenance of Parkinsonian beta activity. Here we study how the subthalamo-pallidal circuits interact with input signals in the beta frequency band, representing cortical input. We use conductance-based models of the subthalamo-pallidal network and two types of input signals: artificially-generated inputs and input signals obtained from recordings in Parkinsonian patients. The resulting model network dynamics is compared with the dynamics of the experimental recordings from patient's basal ganglia. Our results indicate that the subthalamo-pallidal model network exhibits multiple resonances in response to inputs in the beta band. For a relatively broad range of network parameters, there is always a certain input strength, which will induce patterns of synchrony similar to the experimentally observed ones. This ability of the subthalamo-pallidal network to exhibit realistic patterns of synchronous oscillatory activity under broad conditions may indicate that these basal ganglia circuits are directly involved in the expression of Parkinsonian synchronized beta oscillations. Thus, Parkinsonian synchronized beta oscillations may be promoted by the simultaneous action of both cortical (or some other) and subthalamo-pallidal network mechanisms. Hence, these mechanisms are not necessarily mutually exclusive.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Synchronized Beta-Band Oscillations in a Model of the Globus Pallidus-Subthalamic Nucleus Network under External Input

Ahn

Zauber

Worth

et al. 2016

Front. Comput. Neurosci.

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“…Moreover, the model reproduces experimentally observed patterns of beta activity [14]. The matching of the experimental and model synchrony patterns ensures similarity of the actual and the model phase spaces ( [18,32,33]). So, the considered model may be dynamically adequate for the study of some mechanisms of beta suppression.…”

Section: B Limitations Of Modeling and Robustness Of The Stimulationmentioning

confidence: 56%

Effects of Electrical and Optogenetic Deep Brain Stimulation on Synchronized Oscillatory Activity in Parkinsonian Basal Ganglia

Ratnadurai-Giridharan

Cheung

Rubchinsky

2017

IEEE Trans. Neural Syst. Rehabil. Eng.

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Abstract-Conventional deep brain stimulation (DBS) of basal ganglia uses high-frequency regular electrical pulses to treat Parkinsonian motor symptoms and has a series of limitations. Relatively new and not yet clinically tested optogenetic stimulation is an effective experimental stimulation technique to affect pathological network dynamics. We compared the effects of electrical and optogenetic stimulation of the basal ganglia on the pathological parkinsonian rhythmic neural activity. We studied the network response to electrical stimulation and excitatory and inhibitory optogenetic stimulations. Different stimulations exhibit different interactions with pathological activity in the network. We studied these interactions for different network and stimulation parameter values. Optogenetic stimulation was found to be more efficient than electrical stimulation in suppressing pathological rhythmicity. Our findings indicate that optogenetic control of neural synchrony may be more efficacious than electrical control because of the different ways of how stimulations interact with network dynamics.

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“…In the cortex this is synchrony between different EEG electrodes; in the BG this is synchrony between STN spikes and STN LFP (which may reflect input-output synchrony for STN, which gets substantial synaptic input from the external segment of globus pallidus; see discussion in Park et al, 2010). The levels of synchrony in both brain regions fluctuate in time (e.g., EEG synchrony fluctuations (Ahn & Rubchinsky, 2013) and spike-LFP synchrony fluctuations (Park et al, 2010;Rubchinsky et al, 2012)). Using methods discussed above, the strength of the synchrony may be estimated over relatively short time intervals, allowing determination of the time course of synchrony.…”

Section: Correlation Between Dynamics Of Different Brain Regionsmentioning

confidence: 99%

Interaction of synchronized dynamics in cortex and basal ganglia in Parkinson's disease

Ahn

Zauber

Worth

et al. 2015

Eur J of Neuroscience

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Parkinson's disease pathophysiology is marked by increased oscillatory and synchronous activity in the beta frequency band in cortical and basal ganglia circuits. This study explores the functional connections between synchronized dynamics of cortical areas and synchronized dynamics of subcortical areas in Parkinson's disease. We simultaneously recorded neuronal units (spikes) and local field potentials (LFP) from subthalamic nucleus (STN) and electroencephalograms (EEGs) from the scalp in parkinsonian patients, and analysed the correlation between the time courses of the spike-LFP synchronization and inter-electrode EEG synchronization. We found the (non-invasively obtained) time course of the synchrony strength between EEG electrodes and the (invasively obtained) time course of the synchrony between spiking units and LFP in STN to be weakly, but significantly, correlated with each other. This correlation is largest for the bilateral motor EEG synchronization, followed by bilateral frontal EEG synchronization. Our observations suggest that there may be multiple functional modes by which the cortical and basal ganglia circuits interact with each other in Parkinson's disease: not only may synchronization be observed between some areas in cortex and the basal ganglia, but also synchronization within cortex and within basal ganglia may be related, suggesting potentially a more global functional interaction. More coherent dynamics in one brain region may modulate or activate the dynamics of another brain region in a more powerful way, causing correlations between changes in synchrony strength in the two regions.

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Intermittent neural synchronization in Parkinson’s disease

Cited by 77 publications

References 95 publications

Synchronized Beta-Band Oscillations in a Model of the Globus Pallidus-Subthalamic Nucleus Network under External Input

Synchronized Beta-Band Oscillations in a Model of the Globus Pallidus-Subthalamic Nucleus Network under External Input

Effects of Electrical and Optogenetic Deep Brain Stimulation on Synchronized Oscillatory Activity in Parkinsonian Basal Ganglia

Interaction of synchronized dynamics in cortex and basal ganglia in Parkinson's disease

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