Effects of Electrical and Optogenetic Deep Brain Stimulation on Synchronized Oscillatory Activity in Parkinsonian Basal Ganglia

Ratnadurai-Giridharan, Shivakeshavan; Cheung, Chung C.; Rubchinsky, Leonid L.

doi:10.1109/tnsre.2017.2712418

Cited by 25 publications

(9 citation statements)

References 34 publications

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“…Other optogenetic modeling studies used a bottom-up approach in which relevant brain areas subject to optogenetic stimulation, such as the subthalamic nucleus (STN)—external Globus Pallidus (GPe) subnetwork, are modeled with conductance-based model neurons (Ratnadurai-Giridharan et al, 2017 ). Although limited to only ten STN and ten GPe neurons, the model seems to capture patterns of synchronized oscillatory activity observed in Parkinsonian patients.…”

Section: Discussionmentioning

confidence: 99%

Cocaine-Induced Changes in Low-Dimensional Attractors of Local Field Potentials in Optogenetic Mice

Oprisan

Imperatore

Helms

et al. 2018

Front. Comput. Neurosci.

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Optogenetically evoked local field potential (LFP) recorded from the medial prefrontal cortex (mPFC) of mice during basal conditions and following a systemic cocaine administration were analyzed. Blue light stimuli were delivered to mPFC through a fiber optic every 2 s and each trial was repeated 100 times. As in the previous study, we used a surrogate data method to check that nonlinearity was present in the experimental LFPs and only used the last 1.5 s of steady activity to measure the LFPs phase resetting induced by the brief 10 ms light stimulus. We found that the steady dynamics of the mPFC in response to light stimuli could be reconstructed in a three-dimensional phase space with topologically similar “8”-shaped attractors across different animals. Therefore, cocaine did not change the complexity of the recorded nonlinear data compared to the control case. The phase space of the reconstructed attractor is determined by the LFP time series and its temporally shifted versions by a multiple of some lag time. We also compared the change in the attractor shape between cocaine-injected and control using (1) dendrogram clustering and (2) Frechet distance. We found about 20% overlap between control and cocaine trials when classified using dendrogram method, which suggest that it may be possible to describe mathematically both data sets with the same model and slightly different model parameters. We also found that the lag times are about three times shorter for cocaine trials compared to control. As a result, although the phase space trajectories for control and cocaine may look similar, their dynamics is significantly different.

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Section: Discussionmentioning

confidence: 99%

Cocaine-Induced Changes in Low-Dimensional Attractors of Local Field Potentials in Optogenetic Mice

Oprisan

Imperatore

Helms

et al. 2018

Front. Comput. Neurosci.

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“…Then, upon confirmation of the successful delivery of ChR2 into the large-sized DRG neurons, we tested whether their activity could be manipulated by light stimulation. We specifically compared the afferent volley induced by optical and electrical stimulation because the properties of action potentials induced by the two methods were reported to be different in vitro or in silico preparation (Williams & Entcheva, 2015;Ratnadurai-Giridharan et al 2017). Our results show that (1) AAV9 preferentially transduces medium-to-large-sized DRG neurons, (2) compared with electrically elicited responses, the optically generated volleys in transduced DRG neurons have a higher sensitivity with amplitude of optical stimulation, but a lower sensitivity with stimulus frequency, and (3) afferent volleys evoked by light are sufficient to activate and recruit spinal reflex circuits.…”

Section: Introductionmentioning

confidence: 99%

Optogenetic recruitment of spinal reflex pathways from large‐diameter primary afferents in non‐transgenic rats transduced with AAV9/Channelrhodopsin 2

Kubota

Wupuer

Kudo

et al. 2019

The Journal of Physiology

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Key points We demonstrated optical activation of primary somatosensory afferents with high selectivity to fast‐conducting fibres by means of adeno‐associated virus 9 (AAV9)‐mediated gene transduction in dorsal root ganglion (DRG) neurons. AVV9 expressing green fluorescent protein showed high selectivity and transduction efficiency for fast‐conducting, large‐sized DRG neurons. Compared with conventional electrical stimulation, optically elicited volleys in primary afferents had higher sensitivity with stimulus amplitude, but lower sensitivity with stimulus frequency. Optically elicited dorsal root volleys activated postsynaptic neurons in the segmental spinal pathway. This proposed technique will help establish the causal relationships between somatosensory afferent inputs and neural responses in the CNS as well as behavioural outcomes in higher mammals where transgenic animals are not available. Abstract Previously, fundamental structures and their mode of action in the spinal reflex circuit were determined by confirming their input–output relationship using electrophysiological techniques. In those experiments, the electrical stimulation of afferent fibres was used as a core element to identify different types of reflex pathways; however, a major disadvantage of this technique is its non‐selectivity. In this study, we investigated the selective activation of large‐diameter afferents by optogenetics combined with a virus vector transduction technique (injection via the sciatic nerve) in non‐transgenic male Jcl:Wistar rats. We found that green fluorescent protein gene transduction of rat dorsal root ganglion (DRG) neurons with a preference for medium‐to‐large‐sized cells was achieved using the adeno‐associated virus 9 (AAV9) vector compared with the AAV6 vector (P = 0.021). Furthermore, the optical stimulation of Channelrhodopsin 2 (ChR2)‐expressing DRG neurons (transduced by AAV9) produced compound action potentials in afferent nerves originating from fast‐conducting nerve fibres. We also confirmed that physiological responses to different stimulus amplitudes were comparable between optogenetic and electrophysiological activation. However, compared with electrically elicited responses, the optically elicited responses had lower sensitivity with stimulus frequency. Finally, we showed that afferent volleys evoked by optical stimulation were sufficient to activate postsynaptic neurons in the spinal reflex arc. These results provide new ways for understanding the role of sensory afferent input to the central nervous system regarding behavioural control, especially when genetically manipulated animals are not available, such as higher mammals including non‐human primates.

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“…This is achieved by providing the spur with an electrical signal [12]. Currently, there are two methods of stimulation-conventional electrical stimulation and optogenetic stimulation [13]. Although their biochemical processes are different, both systems require an initial electricity input and follow electrical waves or light illumination.…”

Section: Deep Brain Stimulationmentioning

confidence: 99%

Wireless Power Transfer for Implanted Medical Application: A Review

2020

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With ever-increasing concerns on health and environmental safety, there is a fast-growing interest in new technologies for medical devices and applications. Particularly, wireless power transfer (WPT) technology provides reliable and convenient power charging for implant medical devices without additional surgery. For those WPT medical systems, the width of the human body restricts the charging distance, while the specific absorption rate (SAR) standard limits the intensity of the electromagnetic field. In order to develop a high-efficient charging strategy for medical implants, the key factors of transmission distance, coil structure, resonant frequency, etc. are paid special attention. In this paper, a comprehensive overview of near-field WPT technologies in medical devices is presented and discussed. Also, future development is discussed for the prediction of different devices when embedded in various locations of the human body. Moreover, the key issues including power transfer efficiency and output power are addressed and analyzed. All concerning characteristics of WPT links for medical usage are elaborated and discussed. Thus, this review provides an in-depth investigation and the whole map for WPT technologies applied in medical applications.

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Effects of Electrical and Optogenetic Deep Brain Stimulation on Synchronized Oscillatory Activity in Parkinsonian Basal Ganglia

Cited by 25 publications

References 34 publications

Cocaine-Induced Changes in Low-Dimensional Attractors of Local Field Potentials in Optogenetic Mice

Cocaine-Induced Changes in Low-Dimensional Attractors of Local Field Potentials in Optogenetic Mice

Optogenetic recruitment of spinal reflex pathways from large‐diameter primary afferents in non‐transgenic rats transduced with AAV9/Channelrhodopsin 2

Wireless Power Transfer for Implanted Medical Application: A Review

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