Intermittent Fasting and the Possible Benefits in Obesity, Diabetes, and Multiple Sclerosis: A Systematic Review of Randomized Clinical Trials

Morales-Suárez-Varela, María; Sánchez, Ester Collado; Peraita-Costa, Isabel; Llopis-Morales, Agustín; Castillo, José Miguel Soriano del

doi:10.3390/nu13093179

Cited by 46 publications

(39 citation statements)

References 33 publications

(88 reference statements)

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“…IF refers to a period of voluntary abstinence from food and/ or drink for caloric restriction, or no caloric intake over a specified period of time. 62 There are three types of IF, alternate-day fasting (ADF), periodic fasting, and time-restricted fasting (TRF). 63 The most well-known periodic fasting schedule is 5:2, which means having a regular diet for 5 days a week and fasting or near fasting for 2 days a week.…”

Section: Rationalementioning

confidence: 99%

Current Evidence Concerning Effects of Ketogenic Diet and Intermittent Fasting in Patients with Nonalcoholic Fatty Liver

Sripongpun¹,

Churuangsuk²,

Bunchorntavakul³

2022

J Clin Transl Hepatol

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Nonalcoholic fatty liver disease (NAFLD) is emerging globally, while no therapeutic medication has been approved as an effective treatment to date, lifestyle intervention through dietary modification and physical exercise plays a critical role in NAFLD management. In terms of dietary modification, Mediterranean diet is the most studied dietary pattern and is recommended in many guidelines, however, it may not be feasible and affordable for many patients. Recently, a ketogenic diet and intermittent fasting have gained public attention and have been studied in the role of weight management. This article reviews specifically whether these trendy dietary patterns have an effect on NAFLD outcomes regarding intrahepatic fat content, fibrosis, and liver enzymes, the scientific rationales behind these particular dietary patterns, as well as the safety concerns in some certain patient groups.

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Section: Rationalementioning

confidence: 99%

Current Evidence Concerning Effects of Ketogenic Diet and Intermittent Fasting in Patients with Nonalcoholic Fatty Liver

Sripongpun¹,

Churuangsuk²,

Bunchorntavakul³

2022

J Clin Transl Hepatol

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“…The composition of the intestinal microbiome is altered by IF, which enriches the Bacteroidaceae, Lactobacillaceae, and Prevotellaceae families. The abundance of lactobacilli caused by IF has beneficial effects, such as reducing inflammatory immune responses and aiding in treating MS patients [ 48 ].…”

Section: Reviewmentioning

confidence: 99%

The Role of Diet and Gut Microbiome in Multiple Sclerosis

Jayasinghe¹,

Prathiraja²,

Kayani³

et al. 2022

Cureus

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Multiple sclerosis (MS) is a chronic demyelinating condition of the central nervous system (CNS) characterized by immune-mediated damage to the myelin sheath of nerve cells. Genetic and environmental factors are believed to play a significant role. Unfortunately, the knowledge of therapeutic modalities in MS remains very limited, necessitating the need for novel therapeutic strategies. In the previous decade, there has been an influx of studies on the gut microbiome and its link to various neurological conditions, including MS. Various diets may have favorable effects on the gut microflora and may significantly alter the progression and outcomes of MS. Thus, identifying the merits of various diets and modulating them according to the specific nutritional requirements of MS patients can go a long way toward slowing the progression of the disease. Nutritional interventions and the use of the gut microbiome as diagnostic and therapeutic modalities open a host of new possibilities regarding the disease. In this review, we investigate the role of diet and the gut microbiome in the progression of MS. The functions of the gut-brain axis, antioxidants, vitamins, obesity, and various diets are also covered in this article.

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“… 73 Meanwhile, IF was shown to improve the immune recovery of patients with MS by altering intestinal flora composition and reducing the inflammatory response. 74 By reducing fat, IF not only improves body shape but also diminishes the risk of obesity-related diseases such as dyslipidemia, type 2 diabetes, hypertension, and NAFLD. In preclinical studies, fasting and CR have been shown to prolong life- and healthspan, induce autophagy, and ameliorate symptoms of various diseases, such as CVDs, type 2 diabetes, neurodegenerative diseases, cancer, or ischemic injuries.…”

Section: Evaluation Of the Effect Of Ifmentioning

confidence: 99%

Is Intermittent Fasting Better Than Continuous Energy Restriction for Adults with Overweight and Obesity?

Ye¹,

Zhang²,

Zhi³

et al. 2022

DMSO

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As a popular weight management intervention, intermittent fasting (IF) has been widely applied to the treatment of overweight and obesity in adults. This review describes the different forms and implementation protocols of IF and their effects on body weight, body composition, cardiometabolic risk factors and other diseases. The existing evidence suggests that IF is as effective as continuous energy restriction and may be a feasible and effective approach to weight loss.

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Intermittent Fasting and the Possible Benefits in Obesity, Diabetes, and Multiple Sclerosis: A Systematic Review of Randomized Clinical Trials

Cited by 46 publications

References 33 publications

Current Evidence Concerning Effects of Ketogenic Diet and Intermittent Fasting in Patients with Nonalcoholic Fatty Liver

Current Evidence Concerning Effects of Ketogenic Diet and Intermittent Fasting in Patients with Nonalcoholic Fatty Liver

The Role of Diet and Gut Microbiome in Multiple Sclerosis

Is Intermittent Fasting Better Than Continuous Energy Restriction for Adults with Overweight and Obesity?

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