Is Intermittent Fasting Better Than Continuous Energy Restriction for Adults with Overweight and Obesity?

Ye, Yafei; Zhang, Meixian; Zhi, Lin; Tang, Leiwen

doi:10.2147/dmso.s376409

Cited by 3 publications

(2 citation statements)

References 76 publications

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“…Furthermore, fasting-induced autophagy, a cellular cleaning process, could potentially facilitate the removal of damaged proteins and thereby (Parveen & Alhazmi, 2022) mitigate the accumulation of neurotoxic aggregates that (Ye et al, 2022)contribute to diseases like Alzheimer's.…”

Section: Discussionmentioning

confidence: 99%

Intermittent Fasting as New Approaches as Anti Aging for Preventing Age-associated Diseases

Rosalia,

Sumadi

2023

jppipa, pendidikan ipa, fisika, biologi, kimia

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The aging process is inherently linked to an increased susceptibility to various chronic conditions, such as cardiovascular diseases, diabetes, and neurodegenerative disorders. The aim of this research is to delves into the current body of knowledge surrounding intermittent fasting and its potential implications in preventing age-related diseases. The methodological approach used in this research is systematic review. Research search using PRISMA strategy by searching journal articles from various databases including Scopus, Proquest, Science Direct, CINAHL, and Google Scholar in the last five years from 2019 to 2023. The results of PRISMA found 333 articles identified through the five databases contained in research methods and screened through titles. Result this research is the promising role of intermittent fasting in promoting anti-aging effects and preventing age-associated diseases through its multifaceted influence on cellular and molecular mechanisms. As an innovative avenue, intermittent fasting holds the potential to revolutionize strategies aimed at enhancing healthy aging and longevity. intermittent fasting as new approaches as anti aging for preventing age-associated diseases

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Section: Discussionmentioning

confidence: 99%

Intermittent Fasting as New Approaches as Anti Aging for Preventing Age-associated Diseases

Rosalia,

Sumadi

2023

jppipa, pendidikan ipa, fisika, biologi, kimia

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“…TRE has been shown to result in WL for many, 11 and the process of fasting itself may involve other physiological processes that promote overall health. 12 , 13 , 14 Thus, research suggests that intermittent fasting may lower the risk of certain chronic diseases like Type 2 diabetes 15 and heart disease, 16 while potentially improving metabolic health 15 , 17 , 18 through several mechanisms—most notably WL. In addition, intermittent fasting may also become a lifestyle habit that helps people maintain WL.…”

Section: Introductionmentioning

confidence: 99%

The effectiveness of mobile app usage in facilitating weight loss: An observational study

Huntriss,

Salimgaraev,

Nikogosov

et al. 2024

Obesity Science & Practice

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AimWith increasing rates of global obesity and associated health issues, there is an ever‐increasing need for weight management solutions to be more accessible. Mobile applications offer accessible support systems and have the potential to offer a viable and effective weight management solution as an alternative to traditional healthcare models.ObjectiveTo evaluate the effectiveness of the SIMPLE mobile application for time‐restricted eating in achieving weight loss (WL).MethodsUser data were analyzed between January 2021 and January 2023. In‐app activity was calculated as the proportion of active days over 12, 26 and 52 weeks. A day is considered active if it contains at least one in‐app action (e.g., logging weight, food, fasting, or physical activity). Users were categorized into four in‐app activity levels: inactive (in‐app activity <33%), medium activity (33%–66%), high activity (66%–99%), and maximal activity (100%). Weight change among in‐app activity groups was assessed at 12, 26, and 52 weeks.ResultsOut of 53,482 users, a positive association was found between the use of the SIMPLE app and WL. Active app users lost more weight than their less active counterparts. Active users had a median WL of 4.20%, 5.04%, and 3.86% at 12, 26, and 52 weeks, respectively. A larger percentage of active users—up to 50.26%—achieved clinically significant WL (≥5%) when compared to inactive users. A dose‐response relationship between WL and app usage was found after adjusting for gender, age, and initial Body Mass Index; a 10% increase in app activity correlated with increased WL by 0.43, 0.66 and 0.69 kg at 12, 26, and 52 weeks, respectively.ConclusionsThe study demonstrates that the SIMPLE app enables effective WL directly associated with the level of app engagement. Mobile health applications offer an accessible and effective weight management solution and should be considered when supporting adults to lose weight.

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A Brief Web-Based and Mobile Intervention of Intermittent Fasting with Meal Support for Weight Loss Among Overweight Japanese Adults: A Pilot Study of a Randomized Controlled Trial. (Preprint)

Noda,

Shimamoto,

Kiyohara

et al. 2024

Preprint

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BACKGROUND Intermittent fasting (IF) emerges as a promising dietary approach against obesity, which can be implemented as a feasible and cost-effective web-based strategy. We have developed a Brief Online IF Program (OIF), which features self-administered fasting regimen supported with meals delivery, online guidance, and app messages. OBJECTIVE This pilot study aimed to assess the effectiveness, feasibility, and safety of the OIF among overweight Japanese adults. METHODS Study design was 1:1 randomized controlled trial for 12 weeks. Overweight adults with a body mass index from 23 to <35 were recruited in 1 university, 1 hospital and 2 company offices. For the intervention group, meal replacements for their weekly intermittent fasting were provided and an online guidance was given via Zoom. They were instructed to fast weekly by consuming provided fasting meals and to read the app messages encouraging fasting practices and healthy lifestyles. The control group received only app messages encouraging healthy lifestyles. A non-blinded researcher administered the interventions for both groups. Primary outcome was change in body weight assessed under intention-to-treat, with primary analysis to estimate between-group mean difference, adjusted for sex, age, and baseline weight. Secondary outcomes encompassed laboratory-based measures (body compositions, blood pressures, and biomarkers such as hemoglobin A1c, triglycerides, cholesterols), and questionnaire-based measures (quality of life, total physical activity, adherence to the intervention, adverse events, and freely written feedback on the interventions). RESULTS A total of 57 individuals were enrolled, with 28 allocated to the intervention group and 29 to the control group. At 12 weeks, 25 participants in the intervention group and 27 participants in the control group were followed-up. Baseline median weight was 75.8 kg for the intervention group and 74.8 kg for the control group. The mean weight change was −0.9 (SD 1.9) kg in the intervention group and 0.6 (SD 1.4) kg in the control group. The primary analysis revealed a significant between-group difference of −1.6 (95% CI −2.5 to −0.8; P<.001) kg. However, no significant difference was observed in fat mass change (mean difference −0.1 kg, 95% CI −1.3 to 1.4), but a reduction in muscle mass was implied (mean difference −1.3 kg, 95% CI −2.5 to −0.2). Adherence to the intervention was 79% (22/28) in the intervention group and 59% (17/29) in the control group. No serious adverse events were reported. CONCLUSIONS The 12-week OIF can promote weight loss in overweight adults, but may not result in improvements in body composition. The low dropout rate and modest adherence, with no serious adverse events, indicates the feasibility and safety of the program. The future trial should be conducted with the integration of other components such as consistent mentoring and exercise recommendations to improve body composition and overall health outcomes. CLINICALTRIAL UMIN-CTR UMIN000050437

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Is Intermittent Fasting Better Than Continuous Energy Restriction for Adults with Overweight and Obesity?

Cited by 3 publications

References 76 publications

Intermittent Fasting as New Approaches as Anti Aging for Preventing Age-associated Diseases

Intermittent Fasting as New Approaches as Anti Aging for Preventing Age-associated Diseases

The effectiveness of mobile app usage in facilitating weight loss: An observational study

A Brief Web-Based and Mobile Intervention of Intermittent Fasting with Meal Support for Weight Loss Among Overweight Japanese Adults: A Pilot Study of a Randomized Controlled Trial. (Preprint)

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