2017
DOI: 10.1002/mnfr.201600677
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Abstract: ScopeCalorie restriction (CR) has been shown to extend life‐ and health‐span in model species. For most humans, a life‐long CR diet is too arduous to adhere to. The aim of this study was to explore whether weekly intermittent CR can (1) provide long‐term beneficial effects and (2) counteract diet‐induced obesity in male aging mice.Methods and resultsIn this study, we have exposed C57Bl/6J mice for 24 months to an intermittent (INT) diet, alternating weekly between CR of a control diet and ad libitum moderate‐f… Show more

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Cited by 15 publications
(10 citation statements)
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References 78 publications
(78 reference statements)
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“…If a constant hunger experience is the side effect of a CR diet, even at the long run, it can be questioned whether this suffering is compensated for by living a long and healthy life. Our results endorse the search for alternatives to CR regimen, in which food restriction is not continuously applied, for example, intermittent CR (Brandhorst et al., ; Rusli et al., , ); or CR‐mimetics (Gillespie, Pickering, & Eskiw, ; Ingram & Roth, ), compounds that produces CR‐like effects on longevity without requiring the reduced food intake.…”
Section: Discussionsupporting
confidence: 78%
“…If a constant hunger experience is the side effect of a CR diet, even at the long run, it can be questioned whether this suffering is compensated for by living a long and healthy life. Our results endorse the search for alternatives to CR regimen, in which food restriction is not continuously applied, for example, intermittent CR (Brandhorst et al., ; Rusli et al., , ); or CR‐mimetics (Gillespie, Pickering, & Eskiw, ; Ingram & Roth, ), compounds that produces CR‐like effects on longevity without requiring the reduced food intake.…”
Section: Discussionsupporting
confidence: 78%
“…Under unlimited access to food, all animals including humans tend to consume excess of food that is poorly controlled due to a natural instinct to accumulate fuel reserves for use in times of food scarcity (La Fleur et al, 2014; Harris et al, 2018). Particularly in our modern times, this can lead to overweight and obesity that can cause health problems such as cancer, diabetes, cardiovascular, and neurodegenerative diseases and shortening of life and health spans (Rusli et al, 2017; Friedman, 2018). Restriction of food consumption along with physical activity (Myers et al, 2017) are effective natural strategies known to date to cope with negative consequences of overfeeding, whereas pharmacological approach to decrease weight is likely accompanied by side effects.…”
Section: Introductionmentioning
confidence: 99%
“…The transcriptome profile of mice liver tissue obtained after implementation of CR showed that CR improved the expression of genes associated with health, which were previously modulated by obesity. These data and other research studies collectively indicate that CR promotes beneficial outcomes leading to the expansion of life span [77]. In another study, transcriptomic data of adipose tissue indicated that CR suppresses transcription and activity of genes involved in inflammatory response, for example, the NF-κB signaling molecule gene.…”
Section: Omics Big Data On Aging and Crmentioning
confidence: 57%