Intermittent calorie restriction largely counteracts the adverse health effects of a moderate‐fat diet in aging C57BL/6J mice

Lute, Carolien; Boekschoten, Mark V.; Dijk, M. van; Norren, Klaske van; Menke, Aswin; Müller, Michael; Steegenga, Wilma T.

doi:10.1002/mnfr.201600677

Cited by 16 publications

(12 citation statements)

References 78 publications

(78 reference statements)

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“…If a constant hunger experience is the side effect of a CR diet, even at the long run, it can be questioned whether this suffering is compensated for by living a long and healthy life. Our results endorse the search for alternatives to CR regimen, in which food restriction is not continuously applied, for example, intermittent CR (Brandhorst et al., ; Rusli et al., , ); or CR‐mimetics (Gillespie, Pickering, & Eskiw, ; Ingram & Roth, ), compounds that produces CR‐like effects on longevity without requiring the reduced food intake.…”

Section: Discussionsupporting

confidence: 78%

Plasticity of lifelong calorie‐restricted C57BL/6J mice in adapting to a medium‐fat diet intervention at old age

et al. 2017

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SummaryCalorie restriction (CR) is a dietary regimen that supports healthy aging. In this study, we investigated the systemic and liver‐specific responses caused by a diet switch to a medium‐fat (MF) diet in 24‐month‐old lifelong, CR‐exposed mice. This study aimed to increase the knowledge base on dietary alterations of gerontological relevance. Nine‐week‐old C57BL/6J mice were exposed either to a control, CR, or MF diet. At the age of 24 months, a subset of mice of the CR group was transferred to ad libitum MF feeding (CR‐MF). The mice were sacrificed at the age of 28 months, and then, biochemical and molecular analyses were performed. Our results showed that, despite the long‐term exposure to the CR regimen, mice in the CR‐MF group displayed hyperphagia, rapid weight gain, and hepatic steatosis. However, no hepatic fibrosis/injury or alteration in CR‐improved survival was observed in the diet switch group. The liver transcriptomic profile of CR‐MF mice largely shifted to a profile similar to the MF‐fed animals but leaving ~22% of the 1,578 differentially regulated genes between the CR and MF diet groups comparable with the expression of the lifelong CR group. Therefore, although the diet switch was performed at an old age, the CR‐MF‐exposed mice showed plasticity in coping with the challenge of a MF diet without developing severe liver pathologies.

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Section: Discussionsupporting

confidence: 78%

Plasticity of lifelong calorie‐restricted C57BL/6J mice in adapting to a medium‐fat diet intervention at old age

et al. 2017

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“…Under unlimited access to food, all animals including humans tend to consume excess of food that is poorly controlled due to a natural instinct to accumulate fuel reserves for use in times of food scarcity (La Fleur et al, 2014; Harris et al, 2018). Particularly in our modern times, this can lead to overweight and obesity that can cause health problems such as cancer, diabetes, cardiovascular, and neurodegenerative diseases and shortening of life and health spans (Rusli et al, 2017; Friedman, 2018). Restriction of food consumption along with physical activity (Myers et al, 2017) are effective natural strategies known to date to cope with negative consequences of overfeeding, whereas pharmacological approach to decrease weight is likely accompanied by side effects.…”

Section: Introductionmentioning

confidence: 99%

Every-Other-Day Feeding Decreases Glycolytic and Mitochondrial Energy-Producing Potentials in the Brain and Liver of Young Mice

et al. 2019

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Intermittent fasting is used to reduce body mass in obese adult humans and animals. However, information on the impact of one type of intermittent fasting (IF) called every-other-day feeding (EODF) on young animals is scarce. In this study, 1-month-old mice of both sexes were subjected to a 4-week regimen of EODF using age-matched counterparts fed ad libitum as controls. At the end of EODF exposure, experimental male and female mice weighed 14 and 13% less than the control counterparts. The EODF regimen resulted in lower liver levels of glycogen, glucose, and lactate, but did not affect lactate level in mouse cerebral cortex of both sexes. Activities of key glycolytic enzymes (hexokinase, phosphofructokinase, and pyruvate kinase) in liver of experimental mice were lower than those in controls. In the cerebral cortex, only hexokinase and pyruvate kinase activities were lower than in controls, but phosphofructokinase activity was not affected in IF females and was higher in IF males as compared with ad libitum fed males. Mitochondria isolated from liver of IF mice had lower respiratory control ratios, but those from the cortex had the same values as control animals. The concentration of β-hydroxybutyrate and the activity of β-hydroxybutyrate dehydrogenase were lower in the IF mouse liver, but not changed or enhanced in the IF cerebral cortex. Thus, animal responses to IF do not depend significantly on sex and are directed to decrease energy metabolism to save resources, and the effects are more pronounced in the liver than in the brain.

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“…The transcriptome profile of mice liver tissue obtained after implementation of CR showed that CR improved the expression of genes associated with health, which were previously modulated by obesity. These data and other research studies collectively indicate that CR promotes beneficial outcomes leading to the expansion of life span [77]. In another study, transcriptomic data of adipose tissue indicated that CR suppresses transcription and activity of genes involved in inflammatory response, for example, the NF-κB signaling molecule gene.…”

Section: Omics Big Data On Aging and Crmentioning

confidence: 57%

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

et al. 2020

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Chronic inflammation, a pervasive feature of the aging process, is defined by a continuous, multifarious, low-grade inflammatory response. It is a sustained and systemic phenomenon that aggravates aging and can lead to age-related chronic diseases. In recent years, our understanding of age-related chronic inflammation has advanced through a large number of investigations on aging and calorie restriction (CR). A broader view of age-related inflammation is the concept of senoinflammation, which has an outlook beyond the traditional view, as proposed in our previous work. In this review, we discuss the effects of CR on multiple phases of proinflammatory networks and inflammatory signaling pathways to elucidate the basic mechanism underlying aging. Based on studies on senoinflammation and CR, we recognized that senescence-associated secretory phenotype (SASP), which mainly comprises cytokines and chemokines, was significantly increased during aging, whereas it was suppressed during CR. Further, we recognized that cellular metabolic pathways were also dysregulated in aging; however, CR mimetics reversed these effects. These results further support and enhance our understanding of the novel concept of senoinflammation, which is related to the metabolic changes that occur in the aging process. Furthermore, a thorough elucidation of the effect of CR on senoinflammation will reveal key insights and allow possible interventions in aging mechanisms, thus contributing to the development of new therapies focused on improving health and longevity.

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Intermittent calorie restriction largely counteracts the adverse health effects of a moderate‐fat diet in aging C57BL/6J mice

Cited by 16 publications

References 78 publications

Plasticity of lifelong calorie‐restricted C57BL/6J mice in adapting to a medium‐fat diet intervention at old age

Plasticity of lifelong calorie‐restricted C57BL/6J mice in adapting to a medium‐fat diet intervention at old age

Every-Other-Day Feeding Decreases Glycolytic and Mitochondrial Energy-Producing Potentials in the Brain and Liver of Young Mice

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

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