Plasticity of lifelong calorie‐restricted C57<scp>BL</scp>/6J mice in adapting to a medium‐fat diet intervention at old age

Boekschoten, Mark V.; Borelli, Vincenzo; Sun, Chen; Lute, Carolien; Menke, Aswin; Heuvel, Joost van den; Salvioli, Stefano; Franceschi, Claudio; Müller, Michael; Steegenga, Wilma T.

doi:10.1111/acel.12696

Cited by 8 publications

(5 citation statements)

References 49 publications

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“…In our study, we have seen that most gene expression profiles, relative abundance of microbial genera and levels of metabolites adapted to patterns of the MF mice after the diet switch. Our findings are in agreement with results of our previous study focussing on persistence of the liver transcriptome in these mice [33]. Xu and colleagues recently described persistent microbial patterns after switching from CR to a high-fat diet, although it should be noted that their research was performed in the context of a chemically-induced colon cancer model [25].…”

Section: Discussionsupporting

confidence: 93%

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Lifelong calorie restriction affects indicators of colonic health in aging C57Bl/6J mice

Kok

Lugt

Lute

et al. 2018

The Journal of Nutritional Biochemistry

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Diminished colonic health is associated with various age-related pathologies. Calorie restriction (CR) is an effective strategy to increase healthy lifespan, although underlying mechanisms are not fully elucidated. Here, we report the effects of lifelong CR on indicators of colonic health in aging C57Bl/6J mice. Compared to an ad libitum control and moderate-fat diet, 30% energy reduction was associated with attenuated immune- and inflammation-related gene expression in the colon. Furthermore, expression of genes involved in lipid metabolism was higher upon CR, which may point towards efficient regulation of energy metabolism. The relative abundance of bacteria considered beneficial to colonic health, such as Bifidobacterium and Lactobacillus, increased in the mice exposed to CR for 28 months as compared to the other diet groups. We found lower plasma levels of interleukin-6 and lower levels of various metabolites, among which are bile acids, in the colonic luminal content of CR-exposed mice as compared to the other diet groups. Switching from CR to an ad libitum moderate-fat diet at old age (24 months) revealed remarkable phenotypic plasticity in terms of gene expression, microbiota composition and metabolite levels, although expression of a subset of genes remained CR-associated. This study demonstrated in a comprehensive way that CR affects indicators of colonic health in aging mice. Our findings provide unique leads for further studies that need to address optimal and feasible strategies for prolonged energy deprivation, which may contribute to healthy aging.

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Section: Discussionsupporting

confidence: 93%

“…For the analyses of the microbiota composition and plasma Il6 levels Wy-treated mice were additionally included to increase the statistical power. Results on food intake, body weight development, survival characteristics and liver transcriptome data of the mice have been published elsewhere [33].…”

Section: Animals and Dietsmentioning

confidence: 99%

Lifelong calorie restriction affects indicators of colonic health in aging C57Bl/6J mice

Kok

Lugt

Lute

et al. 2018

The Journal of Nutritional Biochemistry

Self Cite

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“…Thus far, dietary restriction has been the most effective strategy to demonstrate an increase in lifespan across a whole range of investigated species, including nonhuman primates (329,536,547,903,1002,1294,1665). This, once again, highlights diet as a key determinant of healthy aging, possibly via modulation of the gut microbiota.…”

Section: Agingmentioning

confidence: 99%

The Microbiota-Gut-Brain Axis

Cryan

O’Riordan

Cowan

et al. 2019

Physiological Reviews

2,749

2,066

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The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and on our bodies) as one of the key regulators of gut-brain function and has led to the appreciation of the importance of a distinct microbiota-gut-brain axis. This axis is gaining ever more traction in fields investigating the biological and physiological basis of psychiatric, neurodevelopmental, age-related, and neurodegenerative disorders. The microbiota and the brain communicate with each other via various routes including the immune system, tryptophan metabolism, the vagus nerve and the enteric nervous system, involving microbial metabolites such as short-chain fatty acids, branched chain amino acids, and peptidoglycans. Many factors can influence microbiota composition in early life, including infection, mode of birth delivery, use of antibiotic medications, the nature of nutritional provision, environmental stressors, and host genetics. At the other extreme of life, microbial diversity diminishes with aging. Stress, in particular, can significantly impact the microbiota-gut-brain axis at all stages of life. Much recent work has implicated the gut microbiota in many conditions including autism, anxiety, obesity, schizophrenia, Parkinson’s disease, and Alzheimer’s disease. Animal models have been paramount in linking the regulation of fundamental neural processes, such as neurogenesis and myelination, to microbiome activation of microglia. Moreover, translational human studies are ongoing and will greatly enhance the field. Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.

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“…Mechanistically, CR exerts its benefits through the alteration of the nutrient/growth factor-sensing mTOR signaling, energy-sensing AMPK signaling, stress-fighting forkhead box family O signaling, and SIRTs[55,169-172]. Therefore, CR not only increases the longevity of stem cells but also enhances the performance of niche cells that support stem cells[55,173-176]. Interestingly, most of the compounds that extend the lifespan by improving metabolism, especially those that promote autophagy like metformin and spermidine, are known as CR mimetics[73,174,177,178].…”

Section: Interventions For Rejuvenation Of Aged Stem Cellsmentioning

confidence: 99%

Aging: A cell source limiting factor in tissue engineering

Khorraminejad-Shirazi¹,

Dorvash²,

Estedlal³

et al. 2019

WJSC

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Tissue engineering has yet to reach its ideal goal, i.e. creating profitable off-the-shelf tissues and organs, designing scaffolds and three-dimensional tissue architectures that can maintain the blood supply, proper biomaterial selection, and identifying the most efficient cell source for use in cell therapy and tissue engineering. These are still the major challenges in this field. Regarding the identification of the most appropriate cell source, aging as a factor that affects both somatic and stem cells and limits their function and applications is a preventable and, at least to some extents, a reversible phenomenon. Here, we reviewed different stem cell types, namely embryonic stem cells, adult stem cells, induced pluripotent stem cells, and genetically modified stem cells, as well as their sources, i.e. autologous, allogeneic, and xenogeneic sources. Afterward, we approached aging by discussing the functional decline of aged stem cells and different intrinsic and extrinsic factors that are involved in stem cell aging including replicative senescence and Hayflick limit, autophagy, epigenetic changes, miRNAs, mTOR and AMPK pathways, and the role of mitochondria in stem cell senescence. Finally, various interventions for rejuvenation and geroprotection of stem cells are discussed. These interventions can be applied in cell therapy and tissue engineering methods to conquer aging as a limiting factor, both in original cell source and in the in vitro proliferated cells.

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Plasticity of lifelong calorie‐restricted C57BL/6J mice in adapting to a medium‐fat diet intervention at old age

Cited by 8 publications

References 49 publications

Lifelong calorie restriction affects indicators of colonic health in aging C57Bl/6J mice

Lifelong calorie restriction affects indicators of colonic health in aging C57Bl/6J mice

The Microbiota-Gut-Brain Axis

Aging: A cell source limiting factor in tissue engineering

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