Intermittent auscultation (IA) of fetal heart rate in labour for fetal well-being

Martis, Ruth; Emilia, Ova; Nurdiati, Detty Siti

doi:10.1002/14651858.cd008680

Cited by 22 publications

(24 citation statements)

References 22 publications

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“…The diagnostic odds ratio (DOR), positive likelihood ratio (PLR), and negative likelihood ratio (NLR) were also included. Then, the SEN and SPE were determined using a bivariate summary ROC (SROC) curve [26], and the AUC and 95% CIs were calculated [27]. We thus obtained the pooled sensitivity, specificity and the summary AUC of each miRNA and its frequency in all included profiles.…”

Section: Diagnostic Value Assessment For Mirnamentioning

confidence: 99%

Integrating MicroRNA Expression Profiling Studies to Systematically Evaluate the Diagnostic Value of MicroRNAs in Pancreatic Cancer and Validate Their Prognostic Significance with the Cancer Genome Atlas Data

Zhang

Pan

et al. 2018

Cell Physiol Biochem

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Background/Aims: MicroRNAs (miRNAs) are promising biomarkers for pancreatic cancer (PaCa). However, systemic and unified evaluations of the diagnostic value of miRNAs are lacking. Therefore, we performed a systematic evaluation based on miRNA expression profiling studies. Methods: We obtained miRNA expression profiling studies from Gene Expression Omnibus (GEO) and ArrayExpress (AE) databases and calculated the pooled sensitivity, specificity, and summary area under a receiver operating characteristic (ROC) curve for every miRNA. According to the area under the curve (AUC), we identified the miRNAs with diagnostic potentiality and validated their prognostic role in The Cancer Genome Atlas (TCGA) data. Gene Ontology (GO) annotations and pathway enrichments of the target genes of the miRNAs were evaluated using bioinformatics tools. Results: Ten miRNA expression profiling studies including 958 patients were used in this diagnostic meta-analysis. A total of 693 miRNAs were measured in more than 9 studies. The top 50 miRNAs with high predictive values for PaCa were identified. Among them, miR-130b had the best predictive value for PaCa (pooled sensitivity: 0.73 [95% confidence intervals (CI) 0.44-0.91], specificity: 0.81 [95% CI 0.59–0.93], and AUC: 0.84 [95% CI 0.73–0.95]). We identified nine miRNAs (miR-23a, miR-30a, miR-125a, miR-129-1, miR-181b-1, miR-203, miR-221, miR-222, and miR-1301) associated with overall survival in PaCa patients by combining our results with TCGA data. The results of a Cox model revealed that two miRNAs (miR-30a [hazard ratio (HR)=2.43, 95% CI 1.05-5.59; p=0.037] and miR-203 [HR=3.14, 95% CI 1.28-7.71; p=0.012]) were independent risk factors for prognosis in PaCa patients. In total, 405 target genes of the nine miRNAs were enriched with Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, and cancer-associated pathways such as Ras signaling pathways, phospholipase D signaling pathway, and AMP-activated protein kinase (AMPK) signaling pathway were revealed among the top 20 enriched pathways. There were significant negative correlations between miR-181b-1 and miR-125a expression levels and the methylation status of their promoter region. Conclusion: Our study performed a systematic evaluation of the diagnostic value of miRNAs based on miRNA expression profiling studies. We identified that miR-23a, miR-30a, miR-125a, miR-129-1, miR-181b-1, miR-203, miR-221, miR-222, and miR-1301 had moderate diagnostic value for PaCa and predicted overall survival in PaCa patients.

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Section: Diagnostic Value Assessment For Mirnamentioning

confidence: 99%

Integrating MicroRNA Expression Profiling Studies to Systematically Evaluate the Diagnostic Value of MicroRNAs in Pancreatic Cancer and Validate Their Prognostic Significance with the Cancer Genome Atlas Data

Zhang

Pan

et al. 2018

Cell Physiol Biochem

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“…Devane et al 2017 compared the effects of admission CTG with intermittent auscultation of the FHR on maternal and infant outcomes for pregnant women without risk factors on their admission to the labour ward. 12 They reviewed four trials involving more than 13,000 women. Although not statistically significant using a strict P < 0.05 criterion, data are consistent with women allocated to admission CTG having on average a higher probability of an increase in incidence of caesarean section than women allocated to intermittent auscultation (Risk ratio (RR) 1.20.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Evaluation of Electronic Foetal Monitoring vs Intermittent Auscultation After an Initial Screening Admission Test and Its Impact on Neonatal Outcome

Malik¹,

Choudhary²,

Madan³

et al. 2018

jemds

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BACKGROUND Continuous electronic foetal monitoring is presumably a superior method of screening for foetal hypoxia as it detects subtle changes in the foetal heart, which can be missed on auscultation. However, in developing countries like India, with limited number of cardiotocography machines available, it was endeavoured to find out if after an initial 20 minutes electronic recording of the foetal heart auscultation could be substituted for electronic foetal monitoring for intrapartum foetal surveillance even in women with category II admission test who were considered to be at high risk for intrapartum foetal hypoxia. Aim: To comparatively study, in women with category II admission test, the neonatal outcome with electronic foetal monitoring and intermittent auscultation. MATERIALS AND METHODS 42 women with category II admission test were randomly divided into two groups: Group I was monitored with intermittent auscultation and Group II received continuous electronic foetal monitoring. RESULTS Operative vaginal delivery for foetal distress was used in 14.28% cases in Group I as compared to 19% in Group II, but the difference was not statistically significant (p= 0.67). Caesarean section for the indication of foetal distress was performed in 47.62% cases in the intermittent auscultation group and 52.38% cases in Group II (p= 0.54). There was no statistically significant difference in the neonatal morbidity and mortality in the two groups. CONCLUSION An admission test followed by intermittent auscultation with stethoscope during and after uterine contractions should be the mainstay of foetal monitoring in labour and is the best way of using the limited number of foetal monitors available in developing countries with economic constraints.

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“…4,9,10 The American College of Obstetricians and Gynecologists states that either IA or continuous EFM is acceptable for the woman without complications. 5 While a systematic review of IA for labor surveillance is in the protocol stage, 11 neither the criteria that define low risk nor the methodology for conducting IA has been universally developed or accepted. 4,12,13 During IA, the fetal heart rate is auscultated between contractions to establish the baseline rate.…”

Section: Intermittent Auscultationmentioning

confidence: 99%

Intermittent Auscultation of the Fetal Heart Rate During Labor: An Opportunity for Shared Decision Making

Hersh¹,

Megregian²,

Emeis³

2014

J Midwife Womens Health

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Electronic fetal heart rate monitoring is the most common form of intrapartal fetal assessment in the United States. Intermittent auscultation of the fetal heart rate is an acceptable option for low-risk laboring women, yet it is underutilized in the hospital setting. Several expert organizations have proposed the use of intermittent auscultation as a means of promoting physiologic childbirth. Within a shared decision-making model, the low-risk pregnant woman should be presented with current evidence about options for fetal heart rate assessment during labor.

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Intermittent auscultation (IA) of fetal heart rate in labour for fetal well-being

Cited by 22 publications

References 22 publications

Integrating MicroRNA Expression Profiling Studies to Systematically Evaluate the Diagnostic Value of MicroRNAs in Pancreatic Cancer and Validate Their Prognostic Significance with the Cancer Genome Atlas Data

Integrating MicroRNA Expression Profiling Studies to Systematically Evaluate the Diagnostic Value of MicroRNAs in Pancreatic Cancer and Validate Their Prognostic Significance with the Cancer Genome Atlas Data

A Comparative Evaluation of Electronic Foetal Monitoring vs Intermittent Auscultation After an Initial Screening Admission Test and Its Impact on Neonatal Outcome

Intermittent Auscultation of the Fetal Heart Rate During Labor: An Opportunity for Shared Decision Making

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