“…With its capability to probe tissues with l D below the micrometer scale, transient anomalous diffusion (tAD) ( Capuani and Palombo, 2020 ) and its new local parameters would dramatically increase DMRI diagnostic potential in detecting collective, micro and sub-micro architectural changes of human tissues due to pathological damage. Anomalous diffusion ( Metzler and Klafter, 2000 ; Burov et al, 2011 ; Metzler et al, 2014 ; Chakraborty and Roichman, 2020 ) is ubiquitously observed in many complex biological systems, ranging from soft matter, e.g., the cell cytoplasm, membrane ( Saxton and Jacobson, 1997 ; Tolić-Nørrelykke et al, 2004 ; Golding and Cox, 2006 ; Zaid et al, 2009 ; Weigel et al, 2011 ; Javanainen et al, 2012 ; Hofling and Franosch, 2013 ; Honigmann et al, 2013 ; Jeon et al, 2016 ; Metzler et al, 2016 ; Pöschke et al, 2016 ) and, extracellular space (ECS) ( Sykovà and Nicholson, 2008 ; Sherpa et al, 2014 ; Nicholson, 2015 ; Xiao et al, 2015 ) to the nucleus ( Bronstein et al, 2009 ; Stadler and Weiss, 2017 ; Pierro et al, 2018 ) and neuro-physiological systems ( Allegrini et al, 2015 ; Paradisi and Allegrini, 2017 ).…”