Intermedins A and B; New metabolites from Schisandra propinqua var. intermedia

Li, Hongmei; Lei, Chun; Luo, Yongming; Li, Xiaonian; Li, Xiaolei; Pu, Jian‐Xin; Zhou, San-Yun; Li, Rong‐Tao; Sun, Han‐Dong

doi:10.1007/s12272-001-1213-6

Cited by 18 publications

(6 citation statements)

References 21 publications

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“…No consensus has been reached regarding a single name for this peptide, and it is now generally referred to by both names as AM2/IMD (Hong et al, ). It is important to note that intermedin is an alternative name for melanocyte‐stimulating hormone and was also used to describe plant compounds (Li et al, ). The dual name for AM2/IMD may cause confusion, especially for those unfamiliar with the field.…”

Section: Unresolved Questions Challenges and Recommendationsmentioning

confidence: 99%

Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25

Hay

Garelja

Poyner

et al. 2017

British J Pharmacology

295

441

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The calcitonin/CGRP family of peptides includes calcitonin, α and β CGRP, amylin, adrenomedullin (AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist of one of two GPCRs, the calcitonin receptor (CTR) or the calcitonin receptor-like receptor (CLR). Further diversity arises from heterodimerization of these GPCRs with one of three receptor activity-modifying proteins (RAMPs). This gives the CGRP receptor (CLR/RAMP1), the AM and AM receptors (CLR/RAMP2 or RAMP3) and the AMY AMY and AMY receptors (CTR/RAMPs1-3 complexes, respectively). Apart from the CGRP receptor, there are only peptide antagonists widely available for these receptors, and these have limited selectivity, thus defining the function of each receptor in vivo remains challenging. Further challenges arise from the probable co-expression of CTR with the CTR/RAMP complexes and species-dependent splice variants of the CTR (CT and CT ). Furthermore, the AMY receptor is activated equally well by both amylin and CGRP, and the preferred receptor for AM2/IMD has been unclear. However, there are clear therapeutic rationales for developing agents against the various receptors for these peptides. For example, many agents targeting the CGRP system are in clinical trials, and pramlintide, an amylin analogue, is an approved therapy for insulin-requiring diabetes. This review provides an update on the pharmacology of the calcitonin family of peptides by members of the corresponding subcommittee of the International Union of Basic and Clinical Pharmacology and colleagues.

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Section: Unresolved Questions Challenges and Recommendationsmentioning

confidence: 99%

Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25

Hay

Garelja

Poyner

et al. 2017

British J Pharmacology

295

441

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“…Compounds 2–12 were identified as 1 β ‐hydroxybisabola‐2,10‐dien‐4‐one ( 2 ), intermedin B ( 3 ), (1 S ,6 S )‐1 α ‐hydroxybiasbol‐2,10‐diene‐14‐al ( 4 ), 3,4‐seco‐biasbol‐10‐ene‐3‐one‐1,4‐olide ( 5 ), ethyl 3‐hydroxy‐4‐methoxyphenylacetate ( 6 ), dihydroferulic acid ethyl ester ( 7 ), 4‐hydroxy‐3‐methoxybenzaldehyde ( 8 ), 4‐hydroxybenzaldehyde ( 9 ), curcumin ( 10 ), demethoxycurcumin ( 11 ), bisdemethoxycurcumin ( 12 ),, respectively. All compounds were characterized by spectroscopic analysis ( 1 H‐NMR, 13 C‐NMR) and comparisons with literature data.…”

Section: Resultsmentioning

confidence: 99%

Isolation, Characterization, and Possible Anti‐Alzheimer's Disease Activities of Bisabolane‐Type Sesquiterpenoid Derivatives and Phenolics from the Rhizomes of Curcuma longa

et al. 2020

Chemistry & Biodiversity

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One new bisabolane-type sesquiterpenoid, together with four known bisabolane-type sesquiterpenoid derivatives and seven phenolics, was isolated from the rhizomes of Curcuma longa. Their structures were elucidated by extensive spectroscopic (IR, HR-ESI-MS, and NMR) data analysis. The possible anti-Alzheimer's disease (AD) activities of the isolated compounds were also evaluated using Caenorhabditis elegans AD pathological model, and 1β-hydroxybisabola-2,10-dien-4-one had the highest possible anti-AD activity.

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“…By analyses of the NMR spectroscopic data and comparison with the literature, the remaining known compounds were elucidated as ar -tumerone, 5 ; turmeronol B, 6 ; turmeronol A, 7 ; intermedin B, 8 ; bisacurone, 9 ; ar -dihydroturmerone, 10 ; curzerenone, 11 ; curcumenol, 12 ; isocurcumenol, 13 ; procurcumenol, 14 ; zedoardiol, 15 ; , and zedoalactone F, 16 …”

Section: Resultsmentioning

confidence: 99%

Absolute Configurations and NO Inhibitory Activities of Terpenoids from Curcuma longa

Kang

et al. 2015

J. Agric. Food Chem.

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Curcuma longa L., belonging to the Zingiberaceae family, is a perennial herb and has been used as a spice and a pigment in the food industry. In the ongoing search for inhibitory reagents of NO production and survey of the chemical composition of natural vegetable foods, the chemical constituents of C. longa used as spice were investigated. This investigation resulted in the isolation of 2 new terpenoids and 14 known analogues. Their structures were established on the basis of the extensive analyses of 1D and 2D NMR spectroscopic data, and the absolute configurations of 1-4 were elucidated by comparison of the calculated and experimental ECD spectra. Among them, compound 1 is a rare norditerpene with an ent-labdane skeleton, and 2 is a skeletally novel sesquiterpene having an eight-membered ring. All of the compounds were found to possess NO inhibitory activities in murine microglial BV-2 cells. The discovery of two new compounds in this chemical investigation further disclosed the chemical composition of C. longa used a food spice, and the bioassay implied that the natural food spice C. longa, containing terpenoids with NO inhibitory activities, may be potentially promotive to human health.

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Intermedins A and B; New metabolites from Schisandra propinqua var. intermedia

Abstract: A new dibenzocyclooctadiene lignan, intermedin A (1), and a new natural bisabolane sesquiterpenoid, intermedin B (2), were isolated from the aerial parts of Schisandra propinqua var. intermedia. Their structures were elucidated on the basis of extensive spectroscopical analysis.

Cited by 18 publications

References 21 publications

Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25

Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25

Isolation, Characterization, and Possible Anti‐Alzheimer's Disease Activities of Bisabolane‐Type Sesquiterpenoid Derivatives and Phenolics from the Rhizomes of Curcuma longa

Absolute Configurations and NO Inhibitory Activities of Terpenoids from Curcuma longa

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