Interlitter variation in progeny of chimaeric male mice

Buehr, Mia; McLaren, Anne

doi:10.1530/jrf.0.0720213

Cited by 14 publications

(8 citation statements)

References 24 publications

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“…As discussed by Buehr & McLaren (1984) there are a number of possible ways in which one sperm type might prove more successful than another in producing young, e.g. more efficient sperm transport in the female tract, more rapid sperm capacitation or differential survival of embryos.…”

Section: Discussionmentioning

confidence: 99%

Interstrain competition amongst mouse spermatozoa inseminated in various proportions, as affected by the genotype of the Y chromosome

Krzanowska¹

1986

Reproduction

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Nonagouti (KP X C57BL)F1 hybrid females were artificially inseminated with a mixture of spermatozoa from males of the KE (nonagouti) and CBA (agouti) strains and the genotype of young was estimated by fur pigmentation. When KE and CBA spermatozoa mixed in the ratios of 1:1, 2:1 and 4:1 were inseminated after ovulation, 87%, 56% and 29% of progeny, respectively, were sired by CBA males, i.e. proportions of CBA progeny were significantly higher than ratios of CBA spermatozoa in the mixture. The surplus of CBA progeny was significantly less in females inseminated before ovulation, which may suggest that more rapid capacitation of CBA spermatozoa is partly responsible for their competitive advantage. In preparations from oviducal flushings of females killed 2-3 h after insemination, CBA spermatozoa (recognized by their shape) were found in similar proportions as in the inseminated mixture. There was therefore no evidence of their preferential selection at the uterotubal junction. No competitive advantage of CBA spermatozoa occurred when they were inseminated with spermatozoa from males of the KE.CBA strain, congenic with KE but with the Y chromosome derived from the CBA strain. This indicates that genetic factors linked with the Y chromosome may influence competitive ability of spermatozoa.

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Section: Discussionmentioning

confidence: 99%

Interstrain competition amongst mouse spermatozoa inseminated in various proportions, as affected by the genotype of the Y chromosome

Krzanowska¹

1986

Reproduction

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“…This phenomenon has been reported by others (Mintz. 1968;McLaren, 1975, 1978: Buehr and McLaren, 1984. The fact that in the present investigation the composition of the spermatogonial compartment and of the Ml and Mil spermato cytes was known helps to explain this variance.…”

Section: Discussionmentioning

confidence: 57%

“…A reduction in the size of the spermatogonial compartment, in combination w'ith selective differences at haplophase, automatically increase vari ances in the ratios born within litters. In the work of Buehr and McLaren (1984). part of the variance could be removed by avoiding delayed fertilization.…”

Section: Discussionmentioning

confidence: 99%

Transmission of gametes with normal or translocation chromosomes in male and female single-sex mouse chimeras

Boer

Hoeven²,

Schøller³

1992

Cytogenet Genome Res

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Three male and four female mouse single-sex chimeras derived from fusions of Rb(11.13)4Bnr T(1;13)70H homozygous embryos with +/+ embryos were caged with T(1;13)70H homozygotes of the opposite sex and followed through their reproductive lifespans. Six animals (three males and three females) were germline chimeras. The fz gene was used as a marker for the T70H reciprocal translocation. The ratio fzfz to fz/+ offspring did not change with increasing age in males, but decreased in two of the three female chimeras. Within males, there was generally good agreement between the proportions of translocation and nontranslocation germ cells from spermatogonial mitosis through the first and second meiotic division. In one male, this ratio was also reflected in the offspring. In the other two males, there was significant selection during haplophase, from which both types of spermatozoa could benefit.

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“…Since glycolysis is important for ATP generation and fertilization in mouse sperm (Fraser and Quinn, 1981), this would compromise sperm function. Other unknown genetic differences may also result in sperm selection in mixed inseminations as described elsewhere (Edwards, 1955;Overstreet and Adams, 1971;Sharma and Hays, 1975;Buehr and McLaren, 1984;Olds-Clarke, 1988).…”

Section: Discussionmentioning

confidence: 99%

“…If, as in our AI experiments, ovulation had already occurred or was occurring at the time of insemination, sperm with more rapid motility, capacitation, or fertilization would be at an advantage. For example, competition between sperm from different mouse strains incorporated into male chimeras was only apparent when mating occurred after ovulation (Buehr and McLaren, 1984). Conversely, prolonged motility or survival might confer a selective advantage if ovulation occurred later and sperm were already waiting in the oviduct (see Braden, 1958;McGrath and Hillman, 1980;Olds-Clarke, 1988, 1997 for discussion).…”

Section: Discussionmentioning

confidence: 99%

Failure of founder transgenic male mice to transmit an attenuated HSV thymidine kinase transgene results from mosaicism and sperm competition

et al. 2000

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Interlitter variation in progeny of chimaeric male mice

Cited by 14 publications

References 24 publications

Interstrain competition amongst mouse spermatozoa inseminated in various proportions, as affected by the genotype of the Y chromosome

Interstrain competition amongst mouse spermatozoa inseminated in various proportions, as affected by the genotype of the Y chromosome

Transmission of gametes with normal or translocation chromosomes in male and female single-sex mouse chimeras

Failure of founder transgenic male mice to transmit an attenuated HSV thymidine kinase transgene results from mosaicism and sperm competition

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