Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases

The immune network in thyroid cancer

“…19,20 IL-24 belongs to the IL-10 gene family and is a potent inhibitor of cancer cell proliferation. 21 IL-24 was induced by RET/ PTC3 expression in thyreocytes of RET/PTC3 transgenic mice and it was involved in autocrine growth/survival of RET/ PTC3-expressing thyroid cells supporting its role in early cellular transformation. However, its expression decreased in poorly differentiated mouse tumors, paralleling the loss of RET/PTC3 expression along with tumor progression, thus supporting a role for IL-24 as tumor suppressor factor.…”

“…28 IL-17A is produced mainly by CD4 C Th17 cells but IL-17-producing CD8 C T cells (Tc17 cells) have also been identified in humans. 21 Th17 and Tc17 cells have been found in many human cancers and IL-17 was associated with both protumor or antitumor responses. 21,29 The protumorigenic effects of IL-17 include the promotion of angiogenesis, survival and the recruitment of Myeloid-derived suppressor cells (MDSCs).…”

“…21 Th17 and Tc17 cells have been found in many human cancers and IL-17 was associated with both protumor or antitumor responses. 21,29 The protumorigenic effects of IL-17 include the promotion of angiogenesis, survival and the recruitment of Myeloid-derived suppressor cells (MDSCs). TC patients display higher Th17 and lower Tc17 cell proportion in peripheral blood compared to controls.…”

“…18 CD4 C IL17 C T cells (Th17) cells can exert protumor or antitumor functions depending on tissue microenvironment. 21 Only one paper examined the prevalence and distribution of Th17 cells in TC samples. In peripheral blood and tissue samples of PTC patients, increased Th17 levels were found compared to healthy controls, whereas the percentage of CD8 C IL-17 C T cells (Tc17) in the peripheral blood was reduced.…”

Diurnal and seasonal changes in <i>IL-6</i> and <i>IL-18</i> gene expression in blood leukocytes of male chickens with experimental peritonitis: the impact of lighting conditions and melatonin

“…The level of mRNAs encoding pro-inflammatory interleukins-6 (IL-6) and -18 (IL-18), known to exert a broad spectrum of biological activities, was evaluated. Chicken IL-6, similarly to its mammalian counterpart, is a multifunctional cytokine produced during systemic inflammation in response to stimuli like LPS, IL-1α or tumor necrosis factor (TNF-α) (Akdis et al, 2011). In innate immunity, IL-6 directs leukocyte trafficking and activation, induces the production of acute-phase proteins, and subsequently promotes T-cell proliferation, B-cell differentiation and survival.…”