Interleukins 1β and 10 Expressions in the Periimplant Crevicular Fluid From Patients With Untreated Periimplant Disease

Casado, Priscila Ladeira; Canullo, Luigi; Filardy, Alessandra A.; Granjeiro, José Mauro; Barboza, Eliane Porto; Duarte, Maria Eugênia Leite

doi:10.1097/id.0b013e3182818792

Cited by 57 publications

(97 citation statements)

References 31 publications

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“…Our findings confirmed those of many previous studies regarding the proinflammatory role of IL-1β11,15. In the current study, we assessed a healthy tooth, a healthy implant, and an implant with peri-implantitis all in the same patient as one important inclusion criterion.…”

Section: Discussionsupporting

confidence: 90%

Assessment of interleukin-1beta and interleukin-6 in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth: a cross-sectional study

Yaghobee

Khorsand

Ghohroudi

et al. 2014

J Korean Assoc Oral Maxillofac Surg

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ObjectivesThis study aimed to assess and compare the levels of interleukin-1beta (IL-1β) and interleukin-6 (IL-6) in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth.Materials and MethodsThis study evaluated 16 dental implants in 8 patients (4 males and 4 females). These patients had at least one healthy implant and one implant with peri-implantitis next to healthy teeth. The crevicular fluid was collected using absorbent cones and transferred to the laboratory. Specimens were evaluated by ELISA for interleukin levels. Data were analyzed using repeated measures ANOVA and Bonferroni tests (P<0.05).ResultsLevels of IL-1β in the crevicular fluid around implants with peri-implantitis were significantly higher than around healthy implants (P=0.002); the latter was significantly higher than around healthy teeth (P=0.015). A significant difference was found in the level of IL-6 in the crevicular fluid around implants with peri-implantitis and healthy implants (P=0.049) and also between implants with peri-implantitis and healthy teeth (P<0.001).ConclusionWithin the limitations of this study, significant differences exist in the levels of IL-1β and IL-6 in the crevicular fluid of implants with peri-implantitis, healthy implants, and healthy teeth. More studies with larger sample sizes in different populations are necessary.

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Section: Discussionsupporting

confidence: 90%

Assessment of interleukin-1beta and interleukin-6 in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth: a cross-sectional study

Yaghobee

Khorsand

Ghohroudi

et al. 2014

J Korean Assoc Oral Maxillofac Surg

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“…It was confirmed that higher concentrations of TNF-α, IL-17 and IL-1β are present in PICF collected from peri-implantitis-affected sites, compared to healthy controls (Ataoglu et al 2002;Curtis et al 1997;Darabi et al 2013;Vieira et al 2013;Severino et al 2011), whereas the opposite was the case for anti-inflammatory cytokine IL-10 (Casado et al 2013). More recently multiplex cytokine arrays have been applied in the analysis of PICF, allowing for a broader simultaneous screening of multiple inflammatory cytokines and chemokines.…”

mentioning

confidence: 61%

Peri-Implant Infections of Oral Biofilm Etiology

Belibasakis

Charalampakis

Bostancı

et al. 2014

Advances in Experimental Medicine and Biology

106

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Biofilms are complex microbial communities that grow on various surfaces in nature. The oral micobiota tend to form polymicrobial biofilms, particularly on the hard mineralized surfaces of teeth, which may impact on oral health and disease. They can cause inflammation of the adjacent tooth-supporting (periodontal) tissues, leading to destructive periodontal disease and tooth loss. The emergence of osseointegrated dental implants as a restorative treatment option for replacing missing teeth has also brought along new artificial surfaces within the oral cavity, on which oral bacteria can form biofilms. As in the case of natural teeth, biofilms on implant surfaces may also trigger infection and cause inflammatory destruction of the peri-implant tissue (i.e. peri-implantitis). While there are strong similarities in the composition of the mixed microbial flora between periodontal and peri-implant infections, there are also a few distinctive differences. The immunological events underlying the pathogenesis of peri-implant infections are qualitatively similar, yet more extensive, compared to periodontal infections, resulting in a faster progression of tissue destruction. This chapter summarizes the current knowledge on the microbiology and immunology of peri-implant infections, including findings from the peri-implant crevicular fluid, the inflammatory exudate of the peri-implant tissue. Moreover, it discusses the diagnosis and current approaches for the treatment of oral infections.

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“…Concentrations of the classical anti-inflammatory cytokines IL-4 and IL-10 were analyzed in few studies. In implants with peri-implantitis, similar [57,58] or lower [55] levels of IL-4 and/or IL-10 were reported, despite that higher levels of IL-10 were also described [52]. …”

Section: Bone Cells Activity During Peri-implantitismentioning

confidence: 97%

Bone Cells Dynamics during Peri-Implantitis: a Theoretical Analysis

Fernandes¹,

Gomes

2016

JOMR

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ObjectivesThe present manuscript aims a detailed characterization of the bone cells dynamics during physiological bone remodelling and, subsequently, to address the cellular and molecular mechanisms that play a fundamental role in the immune-inflammatory-induced uncoupled bone remodelling observed in peri-implantitis.ResultsAn intimate relationship between the immune system and bone is acknowledged to be determinant for bone tissue remodelling and integrity. Due to the close interaction of immune and bone cells, the two systems share a number of surface receptors, cytokines, signalling pathways and transcription factors that are involved in mutual regulatory mechanisms. This physiological equilibrium is disturbed in pathological conditions, as verified in peri-implantitis establishment and development. Activation of the innate and adaptive immune response, challenged by the local bacterial infection, induces the synthesis of high levels of a variety of pro- and anti-inflammatory cytokines that disturb the normal functioning of the bone cells, by uncoupling bone resorption and formation, ending up with a net alveolar bone loss and subsequent implant failure. Most data points to an immune-inflammatory induced osteoclast differentiation and function, as the major underlying mechanism to the uncoupled bone resorption to bone formation. Further, the disturbed functioning of osteoblasts, reflected by the possible expression of a fibro-osteoblastic phenotype, may also play a role.ConclusionsAlveolar bone loss is a hallmark of peri-implantitis. A great deal of data is still needed on the cellular and humoral crosstalk in the context of an integrated view of the osteoimmunologic interplay occurring in the peri-implantitis environment subjacent to the bone loss outcome.

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Interleukins 1β and 10 Expressions in the Periimplant Crevicular Fluid From Patients With Untreated Periimplant Disease

Cited by 57 publications

References 31 publications

Assessment of interleukin-1beta and interleukin-6 in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth: a cross-sectional study

Assessment of interleukin-1beta and interleukin-6 in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth: a cross-sectional study

Peri-Implant Infections of Oral Biofilm Etiology

Bone Cells Dynamics during Peri-Implantitis: a Theoretical Analysis

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