Interleukin (IL)-25 Is Critical For The Development Of Chronic Lung Fibrosis In Mice

Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis

“…These CD14+ circulating cells could be precursors of alternatively activated macrophages, and play a potential role in IPF pathogenesis. In addition to our findings, recent observations on the critical role played by IL-25 in chronic lung fibrosis and IL-17RB in type 2 immune responses increase the likelihood that the unique profile observed by us has considerable biological significance in IPF [10,53,54]. IL-25 has recently been reported to play an essential role in promoting chronic lung fibrosis [10].…”

“…In addition to our findings, recent observations on the critical role played by IL-25 in chronic lung fibrosis and IL-17RB in type 2 immune responses increase the likelihood that the unique profile observed by us has considerable biological significance in IPF [10,53,54]. IL-25 has recently been reported to play an essential role in promoting chronic lung fibrosis [10]. An important innate effector leukocyte population that expresses IL-17RB and expands in response to IL-25 and IL-33 has recently been reported to be essential for mediating type 2 inflammatory responses [53].…”

“…An imbalance between T-helper type 1 (Th1) and T-helper type 2 (Th2) cytokines has also been implicated in IPF pathogenesis [9]. Recently, preliminary observations have indicated a critical role for IL-25 in promoting chronic lung fibrosis in mice [10]. Data reported by us in IPF subjects support and extend to humans the observations in the murine system.…”

“…Activation of alveolar macrophages by the alternative pathway has been reported in herpes virus-induced murine model of progressive pulmonary fibrosis as well as in IPF patients [23]. Recent observations have indicated a critical role for IL-25 in promoting chronic lung fibrosis mediated through the Th2 cytokine IL-13 in mice [10].…”