Interleukin (IL)-17/IL-22-Producing T cells Enriched Within the Liver of Patients with Chronic Hepatitis C Viral (HCV) Infection

Foster, Richard G.; Golden-Mason, Lucy; Rutebemberwa, Alleluiah; Rosen, Hugo R.

doi:10.1007/s10620-011-1997-z

Cited by 77 publications

(68 citation statements)

References 20 publications

(31 reference statements)

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“…Our experiments demonstrated and confirmed a significant increase in frequency of IL-17-and IL-22-secreting Th17 cells in CHC and NAFLD/NASH patients compared to healthy donor [13][14][15] (data not shown).…”

Section: Impact Of Nlcd On Peripheral Il-17-and Il-22-producing Cd161supporting

confidence: 66%

“…Correlation analysis was performed using Pearson correlation test. Sample size was determined on the basis of recent studies [7,14,15] supporting the hypothesis that the Th17 cell frequency, the variable in our cohort of patients, has likely a mean of 3.2%¡2.0. We hypothesized that diet can decrease the Th17 cell frequency to 2.0%¡0.15, power590%, significance level 50.05; for this reason to perform the study, at least 24 patients per group are required.…”

Section: Discussionmentioning

confidence: 97%

“…In particular, Th17 cells have been described as the principal mediators not only in autoimmune diseases but especially in chronic inflammatory disorders [12]. Several authors described an increased amount of circulating and intrahepatic Th17 cells in Chronic Hepatitis C (CHC) patients which correlates with the severity of liver inflammation [13][14][15]. Notably, the development of Th17 cells is reciprocally interconnected with that of regulatory T cells (Treg) [16].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Normocaloric low cholesterol diet modulates Th17/Treg balance in patients with chronic hepatitis C virus infection

Maggio¹,

Viscomi²,

Andrea

et al. 2013

Digestive and Liver Disease

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Section: Impact Of Nlcd On Peripheral Il-17-and Il-22-producing Cd161supporting

confidence: 66%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Normocaloric low cholesterol diet modulates Th17/Treg balance in patients with chronic hepatitis C virus infection

Maggio¹,

Viscomi²,

Andrea

et al. 2013

Digestive and Liver Disease

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“…IL-22 is produced mainly by CD3 + T cells, and to a lesser extent by NKT and NK cells. In Hepatitis C Virus (HCV) infection, IL-22 levels are increased in the liver of patients with viral hepatitis (Dambacher et al 2008;Foster et al 2012). CD4 T cells-producing IL-22 as well as IFN-γ are enriched in the liver compared to blood whereas the percentage of IL-22/IL-17-producing CD4 cells does not differ between liver and blood (Kang et al 2012), suggesting a specific role of these IL-22/IFN-γ double-positive cells.…”

Section: Il-22 In Viral Infectionmentioning

confidence: 99%

Role of IL-22 in Microbial Host Defense

Eidenschenk¹,

Rutz²,

Liesenfeld

et al. 2014

Current Topics in Microbiology and Immunology

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Interleukin (IL)-22 is a member of the IL-10 family of cytokines, which, besides IL-10, contains seven additional cytokines. Although the founding member IL-10 is an important immunoregulatory cytokine that represses both innate and adaptive immunity, the other family members preferentially target epithelial cells and enhance innate host defense mechanisms against various pathogens such as bacteria, yeast, and viruses. Based on their functions, the IL-10 family can be further divided into three subgroups, IL-10 itself, the IL-20 subfamily, and the IFNλ subfamily. IL-22 is the best-studied member of the IL-20 subfamily, and exemplifies the diverse biological effects of this subfamily. IL-22 elicits various innate immune responses from epithelial cells and is essential for host defense against several invading pathogens, including Citrobacter rodentium and Klebsiella pneumonia. IL-22 also protects tissue integrity and maintains the mucosal homeostasis. On the other hand, IL-22 is a proinflammatory cytokine with the capacity to amplify inflammatory responses, which might result in tissue damage, e.g., the IL-22-dependent necrosis of the small intestine during Toxoplasma gondii infection.

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“…Therefore the mediators related to NKT cells such as IL-17 could be involved with hepatitis infections (16,18). Based on our findings the levels of plasma IL-17 in chronic HCV patients were higher than healthy individuals although the difference was not significant (17,(26)(27)(28). Of course this data was in accordant with previous Progression of liver fibrosis by increased liver injury may dominate over the effect of α-GalCer on liver fibrosis, leading to stimulatory effects of a single α-GalCer injection on liver fibrosis induced by NKT cells (16,25).…”

Section: Discussionmentioning

confidence: 61%

Comparison between interleukine-17 levels by NK-T cells in patients with chronic hepatitis C and healthy individuals

et al. 2014

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Background and Aims: Natural killer T (NKT) cells have been suggested to play critical roles in a wide range of immune responses especially against hepatotropic pathogens such as hepatitis C virus (HCV). In the present study, we investigated the status of NKT cells by producing interleukin-17 cytokine in peripheral blood. Materials and Methods: As case-control study, 15 patients with chronic HCV infection and healthy individuals were enrolled in the study. We determined the serum and peripheral blood IL-17 levels after activating by based on Galactosylceramid and IL-2 then the IL-17 level was measured by Enzyme-linked immunosorbentassey (ELISA) methods. Results: Plasma level of IL-17 in patients with chronic infection did not differ compared to the control group (5.5±2.4 vs. 6.2±1.2 pg/ml; p=0.5). The level of supernatant IL-17 was significantly higher in both Galactosylceramid-IL-2-stimulated PBMCs than control group and the ratio IL-17 after 72 h was higher than the other times. The plasma level of IL-17 in HCV 3a-infected patients was higher than 1a-type patients but the difference was not significant (6±2.5 vs. 4.8±2.5 p=0.45). Conclusion:As the recent data, the roles of NKT cells in human liver injury and fibrosis remain unknown. However, the precise role of NKT cells in HCV patients as this play a role in innate immune responses in the liver in higher samples was performed.

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Interleukin (IL)-17/IL-22-Producing T cells Enriched Within the Liver of Patients with Chronic Hepatitis C Viral (HCV) Infection

Abstract: In chronic HCV, T cells producing IL-17/IL-22 may home to the liver; however, circulating levels of IL-17 do not correlate with fibrosis.

Cited by 77 publications

References 20 publications

Normocaloric low cholesterol diet modulates Th17/Treg balance in patients with chronic hepatitis C virus infection

Normocaloric low cholesterol diet modulates Th17/Treg balance in patients with chronic hepatitis C virus infection

Role of IL-22 in Microbial Host Defense

Comparison between interleukine-17 levels by NK-T cells in patients with chronic hepatitis C and healthy individuals

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