Normocaloric low cholesterol diet modulates Th17/Treg balance in patients with chronic hepatitis C virus infection

Maggio, Roberta; Viscomi, C.; Andrea, Paola; d’Ettorre, Gabriella; Barbaro, Barbara; Gori, Manuele; Vullo, Vincenzo; Balsano, Clara

doi:10.1016/j.dld.2013.09.007

Cited by 2 publications

(2 citation statements)

References 30 publications

(36 reference statements)

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“…The balance between Treg and Th17 cells is a key factor that regulates T helper cell function in variety inflammatory autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and chronic hepatitis C [31][32][33]. Several studies have shown that Th17 cells and Treg cells were closely related with lung cancer [25,27,34].…”

Section: Discussionmentioning

confidence: 98%

Disturbed Th17/Treg Balance in Patients with Non-small Cell Lung Cancer

et al. 2015

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The fine balance of T help-17 (Th17)/regulatory T(Treg) cells is crucial for maintenance of immune homeostasis. However, there is little information concerning the role played in non-small cell lung cancer (NSCLC) by Th17/Treg cells. The objective of this study was to investigate the variation of Th17 and Treg cells in the peripheral blood of patients with NSCLC. Blood samples were collected from 19 patients with NSCLC and 19 healthy donors. Samples were processed to detect CD4(+)IL-17(+) Th17 cells and CD4(+)CD25(+)Foxp3(+) Treg cells by flow cytometry, and related gene expressions were assessed by real-time quantitative polymerase chain reaction. The concentrations of interleukin (IL)-1β, IL-6, IL-10, IL-17, IL-23, and transforming growth factor-beta (TGF-β1) were also measured by enzyme-linked immunosorbent assay analysis (ELISA). The frequency of circulating Th17 cells and Treg cells was increased in samples derived from patients with NSCLC, accompanied by the upregulation of Foxp3 and RORγt. However, a negative correlation between Treg cells and Th17 cells was found in patients with NSCLC. Additionally, the Th17/Treg ratio and the related cytokines were also significantly higher in patients with NSCLC than in healthy controls. Furthermore, the frequency of Th17 cells was positively correlated with IL-1β, IL-6, and IL-23 in patients with NSCLC, and the frequency of Treg cells was positively correlated with TGF-β1 and IL-10. More importantly, the Th17/Treg ratio was positively correlated with the CEA concentrations in patients with NSCLC. Our data indicated that Th17 and Treg subset are involved in the immunopathology of NSCLC. Distinct cytokine environment might play a key role in the differentiation of the Th17 and Treg cells in NSCLC. Reconstituting an adequate balance between Th17 and Treg may be beneficial in the treatment of NSCLC.

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Section: Discussionmentioning

confidence: 98%

Disturbed Th17/Treg Balance in Patients with Non-small Cell Lung Cancer

et al. 2015

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“…Core protein is responsible for inducing T‐helper 17 (Th17) cells (Kondo et al, ). Th17 cells are able to produce IL‐17A, IL‐17F, IL‐21, and IL‐22 and express cluster of differentiation 161 (CD161; Maggio et al, ).…”

Section: Introductionmentioning

confidence: 99%

Complexity on modulation of NF‐κB pathways by hepatitis B and C: A double‐edged sword in hepatocarcinogenesis

Shokri

Mahmoudvand

Taherkhani

et al. 2019

Journal Cellular Physiology

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Nuclear factor‐κB (NF‐κB), a family of master regulated dimeric transcription factors, signaling transduction pathways are active players in the cell signaling that control vital cellular processes, including cell growth, proliferation, differentiation, apoptosis, morphogenesis, angiogenesis, and immune responses. Nevertheless, aberrant regulation of the NF‐κB signaling pathways has been associated with a significant number of human cancers. In fact, NF‐κB acts as a double‐edged sword in the vital cellular processes and carcinogenesis. This review provides an overview on the modulation of the NF‐κB signaling pathways by proteins of hepatitis B and C viruses. One of the major NF‐κB events that are modulated by these viruses is the induction of hepatocellular carcinoma. Given the central function of NF‐κB in carcinogenesis, it has turned out to be a considerable therapeutic target for cancer therapy.

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Normocaloric low cholesterol diet modulates Th17/Treg balance in patients with chronic hepatitis C virus infection

Cited by 2 publications

References 30 publications

Disturbed Th17/Treg Balance in Patients with Non-small Cell Lung Cancer

Disturbed Th17/Treg Balance in Patients with Non-small Cell Lung Cancer

Complexity on modulation of NF‐κB pathways by hepatitis B and C: A double‐edged sword in hepatocarcinogenesis

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