Interleukin (Il)-17 as a Biomarker in Assessment of Bronchial Asthma Severity

Kenawy, Eglal M; El-Hafeez, Hafez Abd; EL-Ghaffar, Nagwa Abd; Naeem, Mahmoud M.A.

doi:10.12816/0038267

Cited by 3 publications

(3 citation statements)

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“…[27] Kenawy et al ., 2017 found a highly significant increase in serum level of IgE in patient with severe asthma than those with mild asthma with P values < 0.001. [28] Likewise, a study done by Rotsides and his coworkers (2010) reported a strong positive association between high IgE level and asthma severity in children and they proposed that serum IgE level is a strong predictor for allergy in asthmatic children. [29] Regarding the relation between serum IgE level and the positivity of skin prick test, Baldacci S et al, 1996 concluded that the higher IgE levels the greater the positivity of SPT regardless the gender .…”

Section: Resultsmentioning

confidence: 97%

Association between serum zonulin level and severity of house dust mite allergic asthma

Baioumy,

Ibrahim,

Elgendy

et al. 2024

Preprint

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Background: Increased intestinal permeability, either due to the exposure to antigens in asthmatic patients or due to a barrier defect, play a critical role in susceptibility to environmental allergens. House dust mites allergy occurs more commonly than any other allergens among Egyptian asthmatic patients. Aim: To assess the relation between serum zonulin level as a marker of increased intestinal permeability and the severity of house dust mites allergic asthma. Methods: A case control study which included 96 subjects attending the allergy and immunology unit, microbiology and immunology department, Faculty of medicine, Zagazig University. They were divided into 48 house dust mites allergic asthma and 48 healthy control subjects. Results: On comparing the 2 studied groups, there was a statistically significant difference between the 2 groups concerning serum IgE and serum zonulin levels ( p=0.000, 0.000 respectively)The mean serum zonulin was equal to 258.3±153.01 ng/ml in the asthmatic group and 80±13 ng/ml in the control group. Serum zonulin level significantly increased with the increase of asthma severity (p˂0.001). The cut off value of serum zonulin was ≥ 198 ng/ml, and the area under the curve was 0.76. It displayed sensitivity equal to 80% and specificity equal to 71.4%. Its negative predictive value was equal to 83.3%. Conclusion: Intestinal barrier dysfunction contributes in the pathogenesis of allergic asthma. Serum zonulin level reflects an increase in intestinal permeability and acts as prognostic factor of severity in Asthma. Correction of the gut barrier defect may be an additional novel approach for Asthma.

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Section: Resultsmentioning

confidence: 97%

Association between serum zonulin level and severity of house dust mite allergic asthma

Baioumy,

Ibrahim,

Elgendy

et al. 2024

Preprint

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“…The symptoms of the diseases are curable with medication. [ 2 ] Asthma is believed to be a multifactorial disorder affected not only by genetic predisposition but also by environmental factors.…”

Section: Asthma Overviewmentioning

confidence: 99%

“…[ 139 ] IL-17 may serve as an important biomarker to distinguish atopic and nonatopic asthma. [ 2 ] The IL-17 assays may be incorporated in the routine practice of the primary care physicians while dealing with the severe asthma especially in the case of infant asthma.…”

Section: Diagnostic Biomarkersmentioning

confidence: 99%

An update on the diagnostic biomarkers for asthma

Pandey

Parkash

Kant

et al. 2021

J Family Med Prim Care

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Asthma is a respiratory disorder accounts for ~339 million cases per annum. The initial diagnosis of asthma relies on the symptomatic identification of characters, such as wheeze, shortness of breath, chest tightness, and cough. The presence of two or more of these symptoms may be considered as indicative of asthma. The asthma-diagnostic also involves spirometry test before and after inhaling a bronchodilator like albuterol. Because asthma pathophysiology involves participation of immune system, the cytokines play an important role. The review discusses various molecules that are or may be used as biomarkers for the asthma diagnosis.

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