Interleukin-8 Expression by Head and Neck Squamous Cell Carcinoma

Proinflammatory cytokine levels in oral lichen planus, oral leukoplakia, and oral submucous fibrosis

“…In the present study, serum and salivary TNF-α, IL-6, and IL-8 levels were upregulated in precancerous lesions and conditions. This finding is in line with most previous conducted work 14 15 16 17 , although one study has shown that salivary TNF-α and IL-6 were downregulated 18 19 . This could be due to a small sample size and not using age- or gender-matched samples.…”

“…Serum and salivary TNF-α, IL-6, and IL-8 were higher in advanced stages as compared to early stages of precancerous lesions and conditions, data which supports previous studies 14 15 16 17 18 19 20 21 22 23 24 . TNF-α, IL-6, and IL-8 are potent angiogenic meditators with significant effects on tumor growth, and are associated with increased tumor vessel density and a worsened outcome 15 16 17 18 . Thus, these cytokines might act as surrogate biomarkers of angiogenesis and prognosis.…”

Leukaemia inhibitory factor and interleukin-8 expression in nonmelanoma skin cancers

“…These findings agree with the previous observations on IL‐8 in carcinoma cell lines and primary carcinomas of Woodworth and Simpson, who found lower expression of IL‐8 in the SCC line SiHa than in normal exocervical or endocervical cells 17 . A similar discrepancy between IL‐8 expression in carcinoma cell lines and other primary carcinomas was documented by Cohen et al 18 . These authors demonstrated that IL‐8 expression was enhanced in primary head and neck squamous cell carcinomas (HNSCCA), but diminished in continuous HNSCCA cell lines compared with control cells.…”

Chemokine-Directed Metastasis

“…Other studies have confirmed this observation in prostate cancer models [32]. Similar findings have been shown in gastric carcinoma, breast, head and neck cancer, and colon cancer [33][34][35][36][37][38].…”