Interleukin-6 release in the hepatic blood outflow during normothermic liver ischaemia in humans

Interleukin-6 is a key mediator of the hepatoprotective and pro-proliferative effects of ischaemic preconditioning in mice

“…In the context of liver regeneration, these signalling pathways are mechanistically related to synthesis of IL-6, which is also a putative mediator of hepatoprotection [20,[28][29][30]. In the present studies, ischaemic preconditioning significantly increased hepatic IL-6 mRNA expression during the early stages of prolonged hepatic ischaemia, i.e.…”

Vitamin E Derivative ETS-GS Reduces Liver Ischemia-Reperfusion Injury in Rats

“…We demonstrated that I/R injury was accompanied by cytokine secretion, which was significantly reduced by ETS-GS. Cytokines up-regulated in I/R injury (e.g., TNF-a and IL-6) initiate additional cellular inflammatory responses and can affect liver cell survival, ultimately causing organ injury [7,8]. HMGB1 is a 30-kD nonhistone chromatin-associated protein [9].…”

WITHDRAWN: Alpha-lipoic acid derivate DHLHZn reduces hepatic ischemia/reperfusion injury by inhibition of pro-inflammatory signaling

“…The beneficial effect of DHLHZn may be caused by its anti-inflammatory action. Inflammatory cytokines (TNF-a, IL-6, and others) upregulated in I/R injury initiate additional cellular inflammatory responses and can affect liver cell survival, ultimately causing organ injury [19,20]. Tsuchihashi et al [21] studied the role of cytokines in I/R injury of the liver tissue and suggested that I/R led to expression of TNF-a and IL-6 in the reperfused rat liver model and that expressed cytokines are expected to aggravate I/R injury.…”