Interleukin-6 and perioperative thermoregulation and HPA-axis activation

Jongh, Raf F De; Vissers, Kris; Booij, L.H.D.J.; Jongh, Karen L De; Vincken, Petra; Meert, Theo

doi:10.1016/s1043-4666(03)00093-0

Cited by 22 publications

(14 citation statements)

References 40 publications

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“…[18][19][20] Surgery is followed by an acute-phase response. Plasma IL-6 is a thermoregulatory factor during psychologic, anesthesiologic, and surgical stress 21 and is apparently a major endogenous mediator of fever and acute-phase response. 22,23 Elevated plasma IL-6 level is a suspected cause of postoperative fever.…”

Section: Discussionmentioning

confidence: 99%

Postoperative Fever and Survival in Patients after Open Resection for Colorectal Cancer: A Long-Term Follow-Up Study of 2,311 Prospectively Enrolled Patients

Chen

Changchien

Tang

2008

Diseases of the Colon &Amp; Rectum

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Section: Discussionmentioning

confidence: 99%

Postoperative Fever and Survival in Patients after Open Resection for Colorectal Cancer: A Long-Term Follow-Up Study of 2,311 Prospectively Enrolled Patients

Chen

Changchien

Tang

2008

Diseases of the Colon &Amp; Rectum

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“…Although abdominal surgery is known to cause transient increases in body temperature, the mechanisms that drive these fluctuations in body temperature are not well understood 5 . The aim of the present study was therefore to identify possible mechanisms through which abdominal surgery increases body temperature using experimental rat models.…”

Section: Discussionmentioning

confidence: 99%

“…Decreased body temperature after surgery is a well-known outcome in many patients 2,3 , because surgery is an invasive process that can induce a shock effect to the body 4,5 . In addition, the temperature of the body at rest is slightly lower than while active and most surgical suites are air-conditioned and tend to be very cold 3 .…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, body temperature after surgery may decrease in response to medication administered both before and during procedures 3,6 , while the lack of activity when the patient is on the operating table will slow metabolism and lower heat generation within the body 5 . After surgery, a patient s body temperature is maintained with heated blankets because low postoperative body temperature can cause complications if not corrected promptly.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Hepatectomy on Body Temperature Change in Rats

Otaki

Abe

Mishima

et al. 2014

Showa Univ J Med Sci

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: Abdominal surgery, especially liver resection and transplantation, increases body temperature during and after surgery, but the precise mechanism s underlying this effect are not well understood. The present study thus sought to investigate this phenomenon using an experimental rat model. Speci c pathogenfree male Sprague-Dawley rats, 5 weeks of age, underwent a two-thirds partial hepatectomy PH , one-third splenectomy, or left kidney resection, and then rectal temperature was measured for 5 consecutive days after surgery. Rectal temperature increased in PH rats to a peak on day 4, but no change in temperature was detected after splenectomy and kidney resection. In the second part of the study, we examined the in uence of gadolinium chloride and interleukin-1 monoclonal antibody IL-1 mAb on the increase in rectal temperature following PH. Treatment of rats with 20 mg / kg gadolinium chrolide or 200 µg IL-1 mAb inhibited the PH-induced increase in rectal temperature and decrease in IL-1 and prostaglandin E2, which act as pyrogens to change the thermoregulatory set point in the hypothalamus. These results suggest that abdominal surgery, especially liver resection, caused an increase in endogenous pyrogen production that results in increased body temperature.

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“…4). It has been suggested that IL-6 may serve as a regulator of inflammatory pain and may be essential in the immune-opioid pathway (De Jongh et al, 2003). Systemic administration of anti-IL-6 antibody reduced spinal mOR expression and subsequently increased hyperalgesia.…”

Section: Opioid Tolerance In Neuropathic Painmentioning

confidence: 99%

Neural - Glial Interaction in Neuropathic Pain

Manaheji¹

2012

Basic Principles of Peripheral Nerve Disorders

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Interleukin-6 and perioperative thermoregulation and HPA-axis activation

Cited by 22 publications

References 40 publications

Postoperative Fever and Survival in Patients after Open Resection for Colorectal Cancer: A Long-Term Follow-Up Study of 2,311 Prospectively Enrolled Patients

Postoperative Fever and Survival in Patients after Open Resection for Colorectal Cancer: A Long-Term Follow-Up Study of 2,311 Prospectively Enrolled Patients

Influence of Hepatectomy on Body Temperature Change in Rats

Neural - Glial Interaction in Neuropathic Pain

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