Interleukin‐6 and neopterin levels in the serum and saliva of patients with <i><scp>L</scp>ichen <scp>P</scp>lanus</i> and oral <i><scp>L</scp>ichen <scp>P</scp>lanus</i>

Abdel-Haq, Ayman; Kuśnierz-Cabała, Beata; Darczuk, Dagmara; Sobuta, Eliza; Dumnicka, Paulina; Wojas‐Pelc, Anna; Chomyszyn‐Gajewska, Maria

doi:10.1111/jop.12199

Cited by 37 publications

(13 citation statements)

References 21 publications

(29 reference statements)

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“…Several studies have shown that the cytokine profile in saliva, lesions, and serum of patients with OLP differs from that seen in healthy individuals (Dan et al, ; de Brito Monteiro et al, ; Kaur & Jacobs, ; Kondo & Urisu, ; Liu et al, ; Lu et al, ; Malekzadeh et al, ; Pekiner et al, ; Piccinni et al, ; Simark‐Mattsson et al, ; Wang et al, ; Zhou et al, ). In this study, we found that the serum levels of IL‐6 were higher in the patients than in the healthy control subjects and in accordance with previous findings that also found an association between levels of IL‐6 and the stages of OLP (Abdel‐Haq et al, ; Kaur & Jacobs, ). In our study, the majority of patients (15 out of 19) had erosive or ulcerative OLP lesions at the time of examination.…”

Section: Discussionsupporting

confidence: 92%

Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis

Larsen

Johansen

Reibel

et al. 2017

Clinical & Exp Dental Res

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The objective of this study was to examine if clinical and histopathological variables in patients with oral lichen planus (OLP), oral lichenoid lesions (OLL), and generalized stomatitis display different cytokine profiles and if concomitant contact allergy influences this profile. Forty‐nine patients and 29 healthy age‐ and gender‐matched subjects were included. Demographic and clinical data immunohistochemical findings in mucosal specimens, results of contact allergy testing, and serum levels of tumor necrosis factor‐α, interferon‐γ, interleukin (IL)‐6, IL‐10, IL‐12p40, and IL‐12p70 were analyzed and compared between groups. Nineteen patients had OLP, primarily with ulcerative lesions on the buccal mucosa, 19 patients had OLL, and 11 patients had generalized stomatitis. All patients had oral symptoms, mainly stinging and burning. Nineteen patients and 10 healthy subjects had contact allergies, primarily to fragrance ingredients. Patient groups did not differ with regard to oral symptoms, clinical pattern of the lesions, or contact allergy. Serum cytokine levels did not differ between the different patient groups and were not related to histopathological findings. The patients had higher levels of IL‐6 than the healthy subjects. Interferon‐γ, IL‐12p40, and IL‐12p70 were below detection limit. Our findings indicate that OLP, OLL, and generalized stomatitis cannot be discriminated by means of the selected serum cytokines, and that the presence of concomitant contact allergy does not influence the cytokine expression.

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Section: Discussionsupporting

confidence: 92%

Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis

Larsen

Johansen

Reibel

et al. 2017

Clinical & Exp Dental Res

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“…Plasma cytokines were not concurrently measured. Similar explorations of salivary cytokines with systemic diseases have been reported individually including: inflammatory bowel diseases [42]; pediatric type 1 diabetes [43]; obesity-related sleep apnea [44]; and cutaneous lichen planus [45]. Cytokines elevations were found for IL-8 among 90 salivary proteins after total body irradiation [46], similarly anti-inflammatory cytokine, IL-10, rose in saliva of airway-disease patients when exposed to thermal sulfur water bath therapy [47].…”

Section: Discussionmentioning

confidence: 62%

“…In a survey of the salivary-cytokine literature, we find that the majority involve local conditions arising close to the salivary glands, such as oral inflammation [30,31] or head neck or oral, cancer [32,33]. Our observed dissociation of the cytokine response between the circulating pattern and that in the saliva, moreover, is neither unprecedented nor implausible.…”

Section: Discussionmentioning

confidence: 87%

Associations among Inflammatory Biomarkers in the Circulating, Plasmatic, Salivary and Intraluminal Anatomical Compartments in Apparently Healthy Preschool Children from the Western Highlands of Guatemala

Soto-Méndez¹,

Romero-Abal²,

Aguilera

et al. 2015

PLoS ONE

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BackgroundUndernutrition and inflammation are related in many ways; for instance, non-hygienic environments are associated with both poor growth and immunostimulation in children.ObjectiveTo describe any existing interaction among different inflammation biomarkers measured in the distinct anatomical compartments of whole blood, feces, plasma and saliva.MethodsIn this descriptive, cross-sectional study, samples of whole blood, feces, plasma and saliva were collected on the 8th and last week of observation among 87 attendees (42 girls and 45 boys) of 3 daycare centers offering a common 40-day rotating menu in Guatemala’s Western Highlands. Analyses included white blood cell count (WBC), fecal calprotectin, and plasmatic and salivary cytokines including IL-1B, IL-6, IL-8, IL-10 and TNF-α. Associations were assessed using Spearman rank-order and goodness-of-fit correlations, as indicated, followed by backwards-elimination multiple regression analyses to determine predictor variables for IL-10 in both anatomical compartments.ResultsOf a total of 66 cross-tabulations in the Spearman hemi-matrix, 22 (33%) were significantly associated. All 10 paired associations among the salivary cytokines had a significant r value, whereas 7 of 10 possible associations among plasma cytokines were significant. Associations across anatomical compartments, however, were rarely significant. IL-10 in both biological fluids were higher than corresponding reference values. When a multiple regression model was run in order to determine independent predictors for IL-10 in each anatomical compartment separately, IL-6, IL-8 and TNF-α emerged as predictors in plasma (r2 = 0.514) and IL-1B, IL-8 and TNF-α remained as independent predictors in saliva (r2 = 0.762). Significant cross-interactions were seen with WBC, but not with fecal calprotectin.ConclusionInteractions ranged from robust within the same anatomical compartment to limited to nil across distinct anatomical compartments. The prominence of the anti-inflammatory cytokine, IL-10, in both plasma and saliva is consistent with its counter-regulatory role facing a broad front of elevated pro-inflammatory cytokines in the same compartment.

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“…Due to the fact that saliva can be collected in an easy and noninvasive way, it seems to be a very attractive diagnostic material [34]. Proinflammatory cytokines have also been investigated in saliva as potential biomarkers of OPMDs and OSCC, and the current results are encouraging [24,[35][36][37].…”

mentioning

confidence: 94%

Evaluation of Proinflammatory, NF-kappaB Dependent Cytokines: IL-1α, IL-6, IL-8, and TNF-α in Tissue Specimens and Saliva of Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Babiuch

Kuśnierz-Cabała

Kęsek

et al. 2020

JCM

Self Cite

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Background: Oral squamous cell carcinoma (OSCC) is a life-threatening disease. It could be preceded by oral potentially malignant disorders (OPMDs). It was confirmed that chronic inflammation can promote carcinogenesis. Cytokines play a crucial role in this process. The aim of the study was to evaluate interleukin-1alpha (IL-1α), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-α) in tissue specimens and saliva of patients with OSCC and OPMDs. Methods: Cytokines were evaluated in 60 tissue specimens of pathological lesions (OSCCs or OPMDs) and in 7 controls (normal oral mucosa, NOM) by immunohistochemistry and in saliva of 45 patients with OSCC or OPMDs and 9 controls (healthy volunteers) by enzyme-linked immunosorbent assays. Results: Immunohistochemical analysis revealed significantly higher expression of IL-8 in OSCC specimens and TNF-α in OSCCs and OPMDs with dysplasia as compared to NOM. Moreover, expression of TNF-α was significantly higher in oral leukoplakia and oral lichen planus without dysplasia, whereas expression of IL-8 only in oral leukoplakia without dysplasia in comparison with NOM. Salivary concentrations of all evaluated cytokines were significantly higher in patients with OSCC than in controls. Moreover, levels of IL-8 were significantly higher in saliva of patients with OPMDs with dysplasia as compared to controls and in OSCC patients as compared to patients with dysplastic lesions. There was also significant increase in salivary concentrations of IL-6, IL-8 and TNF-α in patients with OSCC as compared to patients with OPMDs without dysplasia. Conclusion: The study confirmed that proinflammatory, NF-kappaB dependent cytokines are involved in pathogenesis of OPMDs and OSCC. The most important biomarker of malignant transformation process within oral mucosa among all assessed cytokines seems to be IL-8. Further studies on a larger sample size are needed to corroborate these results.

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Interleukin‐6 and neopterin levels in the serum and saliva of patients with Lichen Planus and oral Lichen Planus

Cited by 37 publications

References 21 publications

Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis

Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis

Associations among Inflammatory Biomarkers in the Circulating, Plasmatic, Salivary and Intraluminal Anatomical Compartments in Apparently Healthy Preschool Children from the Western Highlands of Guatemala

Evaluation of Proinflammatory, NF-kappaB Dependent Cytokines: IL-1α, IL-6, IL-8, and TNF-α in Tissue Specimens and Saliva of Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

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