Interleukin-6 and Diabetic Retinopathy: A Systematic Review and Meta-Analysis

Yao, Yang; Li, Rong; Du, Junhui; Long, Lihui; Li, Xiangnan; Luo, Na

doi:10.1080/02713683.2019.1570274

Cited by 45 publications

(31 citation statements)

References 48 publications

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“…Although IL-6 levels in DR (5) has been previously examined to some extent 234 , this present meta-analysis has included additional studies 62 , 65 , 73 , 78 , 79 , 82 , 91 , 92 , 96 , 99 , 101 , 103 , 109 – 112 , 114 , 117 – 120 . The IL-6 levels were found to be higher in DR than in control group (SMD = 2.21, 95% CI 1.74–2.69, P < 0.00001).…”

Section: Resultsmentioning

confidence: 99%

“…Diabetic retinopathy. Although IL-6 levels in DR (5) has been previously examined to some extent 234 , this present meta-analysis has included additional studies 62,65,73,78,79,82,91,92,96,99,101,103,[109][110][111][112]114,[117][118][119][120] . The IL-6 levels were found to be higher in DR Table S4).…”

Section: The Association Between Il-6 Levels and Overall Risk Of Oculmentioning

confidence: 99%

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The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis

Ulhaq

Soraya

Budu

et al. 2020

Sci Rep

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Interleukin-6 (IL-6) is one of the key regulators behind the inflammatory and pathological process associated with ophthalmic diseases. The role of IL-6-174 G/C polymorphism as well as intraocular IL-6 levels among various eye disease patients differ across studies and has not been systematically reviewed. Thus, this study aims to provide a summary to understand the relationship between IL-6 and ophthalmic disease. In total, 8,252 and 11,014 subjects for IL-6-174 G/C and intraocular levels of IL-6, respectively, were retrieved from PubMed, Scopus and Web of Science. No association was found between IL-6-174 G/C polymorphisms with ocular diseases. Subgroup analyses revealed a suggestive association between the GC genotype of IL-6-174 G/C with proliferative diabetic retinopathy (PDR). Further, the level of intraocular IL-6 among ocular disease patients in general was found to be higher than the control group [standardized mean difference (SMD) = 1.41, 95% confidence interval (CI) 1.24–1.58, P < 0.00001]. Closer examination through subgroup analyses yielded similar results in several ocular diseases. This study thus indicates that the IL-6-174 G/C polymorphism does not predispose patients to ocular disease, although the GC genotype is likely to be a genetic biomarker for PDR. Moreover, intraocular IL-6 concentrations are related to the specific manifestations of the ophthalmic diseases. Further studies with larger sample sizes are warranted to confirm this conclusion.

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Section: Resultsmentioning

confidence: 99%

Section: The Association Between Il-6 Levels and Overall Risk Of Oculmentioning

confidence: 99%

The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis

Ulhaq

Soraya

Budu

et al. 2020

Sci Rep

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“…The following data were collected from the included articles: first author, location, publication year, study design, sample size, mean age, sex ratio, type of OCTA, primary outcomes, and quality of a study. The quality assessment of the included studies was performed according to the Newcastle-Ottawa scale, which provided a score range of 0 to 9 points, with a higher score (≥5) indicating better quality [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Optical Coherence Tomography Angiography Assessment of the Peripapillary Vessel Density and Structure in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy: A Meta-Analysis

Ling

Xie

et al. 2020

BioMed Research International

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Background. This meta-analysis is aimed at assessing the peripapillary vessel density (VD) and structural outcomes using optical coherence tomography angiography (OCTA) in patients with nonarteritic anterior ischemic optic neuropathy (NAION). Methods. A comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science databases for literature comparing VD and structural outcomes in patients with NAION and controls was performed. Mean differences (MDs) and its 95% confidence interval (CI) were calculated for continuous estimates. Review Manager (V5.30) was used for analysis. Results. Fourteen published studies met the requirement. The radial peripapillary capillary (RPC) whole enface VD measured by OCTA was significantly lower in patients with NAION compared to that of the controls ( MD = − 10.51 , P < 0.00001 ). The RPC inside disc VD was significantly decreased in the NAION group than that in the control group ( MD = − 8.47 , P < 0.00001 ). For RPC peripapillary VD, there was a statistically significant difference between patients with NAION and the controls ( MD = − 12.48 , P < 0.00001 ). The peripapillary retinal nerve fibre layer (p-RNFL) thickness was significantly lower in patients with NAION in comparison to the controls ( MD = − 22.18 , P = 0.004 ). The ganglion cell complex (GCC) thickness in the macular zone of NAION patients was remarkably reduced compared to that in the controls ( MD = − 17.18 , P = 0.0002 ). Conclusions. The findings suggested that the peripapillary VD and RNFL thickness were attenuated, and the macular GCC thickness was reduced in patients with NAION. OCTA, in the future, may facilitate the diagnosis and monitoring of patients with NAION.

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“…IL-6 can be produced by microglia and astrocytes ( 9 ). Significantly higher intravitreal IL-6 levels are found in patients with NPDR and PDR, ( 75 , 82 , 93 , 94 ) and its intravitreal concentration correlates with the severity of PDR ( 95 ) and retinal macular thickness ( 96 ). Increased intravitreal concentration of IL-6 may be associated with the progression of DR from the NPDR to active PDR ( 95 ).…”

Section: Inflammation and Endothelial Dysfunction Of Drmentioning

confidence: 99%

Endothelial Dysfunction in Diabetic Retinopathy

Gui

You

et al. 2020

Front. Endocrinol.

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Diabetic retinopathy (DR) is a diabetic complication which affects retinal function and results in severe loss of vision and relevant retinal diseases. Retinal vascular dysfunction caused by multifactors, such as advanced glycosylation end products and receptors, pro-inflammatory cytokines and chemokines, proliferator-activated receptor-γ disruption, growth factors, oxidative stress, and microRNA. These factors promote retinal endothelial dysfunction, which results in the development of DR. In this review, we summarize the contributors in the pathophysiology of DR for a better understanding of the molecular and cellular mechanism in the development of DR with a special emphasis on retinal endothelial dysfunction.

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Interleukin-6 and Diabetic Retinopathy: A Systematic Review and Meta-Analysis

Cited by 45 publications

References 48 publications

The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis

The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis

Optical Coherence Tomography Angiography Assessment of the Peripapillary Vessel Density and Structure in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy: A Meta-Analysis

Endothelial Dysfunction in Diabetic Retinopathy

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