Interleukin-31 interaction with inflammasome: A promising diagnostic and prognostic panel for early sepsis identification in critically ill patients

Watany, Mona Mohamed; Elmazny, Maram I.; Nasif, Elham

doi:10.1016/j.cyto.2020.155102

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Thus, arguably, systemic-inflammatory-response syndrome (SIRS) and sepsis could be differentiated by the measurement of IL-31, IL-1ß, and NLRP3. Lower levels of IL-31 are characteristic of sepsis, when compared to SIRS, and even lower levels in the case of septic shock, showing sensitivity up to 80% [ 100 ]. These findings suggest that, by studying further the role of IL-31 in sepsis, bioproducts that could lead to the blockade of IL-31 could be used, in the future, to control the symptoms and complications caused by septic-shock syndromes, in which patients’ survival depends largely on the control of the heavy-inflammatory status.…”

Section: Discussionmentioning

confidence: 99%

IL-31: State of the Art for an Inflammation-Oriented Interleukin

Borgia

Custurone

Pomi

et al. 2022

IJMS

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Interleukin 31 belongs to the IL-6 superfamily, and it is an itch mediator already studied in several diseases, comprising atopic dermatitis, allergic pathologies, and onco-hematological conditions. This research aims to assess the role of this cytokine in the pathogenesis of these conditions and its potential therapeutic role. The research has been conducted on articles, excluding reviews and meta-analysis, both on animals and humans. The results showed that IL-31 plays a crucial role in the pathogenesis of systemic skin manifestations, prognosis, and itch severity. Traditional therapies target this interleukin indirectly, but monoclonal antibodies (Mab) directed against it have shown efficacy and safety profiles comparable with biological drugs that are already available. Future perspectives could include the development of new antibodies against IL-31 both for humans and animals, thus adding a new approach to the therapy, which often has proven to be prolonged and specific for each patient.

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Section: Discussionmentioning

confidence: 99%

IL-31: State of the Art for an Inflammation-Oriented Interleukin

Borgia

Custurone

Pomi

et al. 2022

IJMS

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“…The results demonstrated that the three biomarkers could be independent prognostic biomarkers. A panel of combined markers further yielded 100% sensitivity and specificity, suggesting that the combination of IL-31, IL-1b, and NLRP3 may provide a promising diagnostic and prognostic panel for sepsis (Watany et al, 2020). In addition, Cui et al reported that the absolute number and percentage of ASC-speck + monocytes increased on days 6 and 7 of sepsis, and patients with lower absolute numbers of ASC-speck + monocytes on day 6 showed poor 90-day survival (Cui et al, 2020).…”

Section: Pyroptosis-related Proteins As Indicators To Evaluate the Se...mentioning

confidence: 99%

Molecular mechanisms and functions of pyroptosis in sepsis and sepsis-associated organ dysfunction

Wen

Liu

Tong

et al. 2022

Front. Cell. Infect. Microbiol.

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Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading cause of death in intensive care units. The development of sepsis-associated organ dysfunction (SAOD) poses a threat to the survival of patients with sepsis. Unfortunately, the pathogenesis of sepsis and SAOD is complicated, multifactorial, and has not been completely clarified. Recently, numerous studies have demonstrated that pyroptosis, which is characterized by inflammasome and caspase activation and cell membrane pore formation, is involved in sepsis. Unlike apoptosis, pyroptosis is a pro-inflammatory form of programmed cell death that participates in the regulation of immunity and inflammation. Related studies have shown that in sepsis, moderate pyroptosis promotes the clearance of pathogens, whereas the excessive activation of pyroptosis leads to host immune response disorders and SAOD. Additionally, transcription factors, non-coding RNAs, epigenetic modifications and post-translational modifications can directly or indirectly regulate pyroptosis-related molecules. Pyroptosis also interacts with autophagy, apoptosis, NETosis, and necroptosis. This review summarizes the roles and regulatory mechanisms of pyroptosis in sepsis and SAOD. As our understanding of the functions of pyroptosis improves, the development of new diagnostic biomarkers and targeted therapies associated with pyroptosis to improve clinical outcomes appears promising in the future.

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“…The second step involves the assembly and activation of inflammatory molecular complexes induced by different ligands. 14,15 The inhibition of inflammasomes or neutralization of their products, particularly the interleukins IL-1β and IL-18, has major effects on the development and progression of tumors.…”

Section: Introductionmentioning

confidence: 99%