Interleukin 3 enhanced interleukin 2-dependent maturation of NK progenitor cells in bone marrow from mice with severe combined immunodeficiency

Cytokines transduced bone marrow stromal cell lines promote immunohematopoietic reconstitution in mice after allogeneic bone marrow transplantation

“…3 and 4C). Finally, it was reported that in the presence of low concentration of IL-2, IL-3 could augment NK activity [37], and synergize with IL-2 to stimulate macroghage activation [38]. Therefore, both IL-2 and IL-3 are equally important for rapid reconstitution of hematopoietic and immunologic function in bone marrow stromal mediated gene therapy.…”