Interleukin 28B rs12979860 CT, rs12980275 GA, rs8099917 GT and TT genotypes are the Predictors of Rapid Viral Response in Hepatitis C Virus-Infected Patients

Abstract

ÖZObjective: In this study, the effects of genotypic differences on the clinical course of the disease, response to treatment and fibrosis were investigated in patients with hepatitis C virus (HCV) infection. Materials and Methods: Ninety-nine chronic HCV-infected patients and 95 controls were enrolled. The patients received pegylated interferon (PegIFN) + ribavirin (RBV) for 48 weeks and followed up for the next 48 weeks. Aspartate aminotransferase/platelet ratio index was used to determine the stage of liver fibrosis. DNA specimens were extracted from peripheral blood mononuclear cells and the interleukin (IL) 28B gene rs12979860, rs12980275, and rs8099917 were genotyped by the immune polymerase chain reaction-restriction fragment length polymorphism method.

The association between gene polymorphism of certain cytokines (IL-6, IL-10) and hepatitis C virus infection locally

“…Controlling on the production of these cytokines are a very complicated process, the imbalance in the production of proin lammatory and anti-in lammatory interleukins signi icantly affects on development and persistence of infection with hepatitis C virus (M, 2011) . Our current study deals with the relationship between gene polymorphism of IL-6 and IL-10 and infection with hepatitis C virus through the following aspects ,which includes screening for antibodies to the hepatitis C virus and detection of gene polymorphism of IL-6 and IL-10 Using RFLP-PCR technology and its relationship to the spread of the hepatitis C virus (Alsudani, 2017; Lu et al, 2016) (Rüstemoğlu et al, 2016) .…”

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“…Controlling on the production of these cytokines are a very complicated process, the imbalance in the production of proin lammatory and anti-in lammatory interleukins signi icantly affects on development and persistence of infection with hepatitis C virus (M, 2011) . Our current study deals with the relationship between gene polymorphism of IL-6 and IL-10 and infection with hepatitis C virus through the following aspects ,which includes screening for antibodies to the hepatitis C virus and detection of gene polymorphism of IL-6 and IL-10 Using RFLP-PCR technology and its relationship to the spread of the hepatitis C virus (Alsudani, 2017;Lu et al, 2016) (Rüstemoğlu et al, 2016) .…”