Interleukin-22 Polymorphisms in <i>Plasmodium falciparum</i>-Infected Malaria Patients

Aljarba, Nada H.; Al-Anazi, Mashael R.; Shafeai, Mohammed I; Rudiny, Fuad H; Dajem, Saad M. Bin; Alothaid, Hani; Darraj, Majid; Alkahtani, Saad; Alghamdi, Jahad; Al‐Ahdal, Mohammed N.; Al‐Qahtani, Ahmed

doi:10.1155/2020/5193723

Cited by 8 publications

(8 citation statements)

References 36 publications

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“…These single nucleotide polymorphisms (SNPs) described rendered the patients either more resistant or more susceptible to malaria infection [49]. Similarly, other IL-22-related SNPs identified in different ethnicities have emerged over the years [50,51]. In line with the previous finding, elevated levels of IL-22 have been described in patients infected with Plasmodium species [52,53].…”

Section: Protozoan Infectionsmentioning

confidence: 72%

The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies

et al. 2021

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The human liver fulfills several vital tasks daily and possesses an impressive ability to self-regenerate. However, the capacity of this self-healing process can be exhausted by a variety of different liver diseases, such as alcoholic liver damage, viral hepatitis, or hepatocellular carcinoma. Over time, all these diseases generally lead to progressive liver failure that can become fatal if left untreated. Thus, a great effort has been directed towards the development of innovative therapies. The most recently discovered therapies often involve modifying the patient’s immune system to enhance a beneficial immune response. Current data suggest that, among others, the cytokine IL-22 might be a promising therapeutical candidate. IL-22 and its endogenous antagonist, IL-22BP, have been under thorough scientific investigation for nearly 20 years. While IL-22 is mainly produced by TH22 cells, ILC3s, NKT cells, or γδ T cells, sources of IL-22BP include dendritic cells, eosinophils, and CD4+ cells. In many settings, IL-22 was shown to promote regenerative potential and, thus, could protect tissues from pathogens and damage. However, the effects of IL-22 during carcinogenesis are more ambiguous and depend on the tumor entity and microenvironment. In line with its capabilities of neutralizing IL-22 in vivo, IL-22BP possesses often, but not always, an inverse expression pattern compared to its ligand. In this comprehensive review, we will summarize past and current findings regarding the roles of IL-22 and IL-22BP in liver diseases with a particular focus on the leading causes of advanced liver failure, namely, liver infections, liver damage, and liver malignancies.

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Section: Protozoan Infectionsmentioning

confidence: 72%

The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies

et al. 2021

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“… 32 Aljarba et al found that rs2227481C>T located on IL‐22 could contribute to protection against P. falciparum malaria. 33 However, some studies have shown that rs2227485T>C in IL‐22 might be associated with an increased risk of papillary thyroid cancer and gastric mucosa‐associated lymphoid tissue lymphoma. 34 We demonstrated that rs2227485T>C in IL‐22 has a protective role in COPD.…”

Section: Discussionmentioning

confidence: 99%

“…rs2227478T>C was shown to have protective effects on autoimmune thyroid disease 32 . Aljarba et al found that rs2227481C>T located on IL‐22 could contribute to protection against P. falciparum malaria 33 . However, some studies have shown that rs2227485T>C in IL‐22 might be associated with an increased risk of papillary thyroid cancer and gastric mucosa‐associated lymphoid tissue lymphoma 34 .…”

Section: Discussionmentioning

confidence: 99%

Identification of genetic variants of the IL‐22 gene in association with an altered risk of COPD susceptibility

Wang

Zhou

Chen

et al. 2022

Clinical Respiratory J

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The incidence of chronic obstructive pulmonary disease (COPD) is related to the interaction between environmental exposure and genetic factors. Far more than 15% of smokers eventually develop COPD. In addition to smoking, genetic susceptibility may be another factor in the development of COPD. IL‐22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis. Here, we conducted a case–control study to evaluate the association between IL‐22 tag‐single nucleotide polymorphisms (SNPs) and COPD risk. Four tag‐SNPs (rs2227478, rs2227481, rs2227484 and rs2227485) were identified according to linkage disequilibrium (LD) analysis in 30 healthy controls. A total of 513 COPD cases and 504 controls were recruited to perform an association study between these four tag‐SNPs and COPD risk. We found that the “C” allele of rs2227478T>C and the “T” allele of rs2227481C>T were obviously related to decreased COPD susceptibility. Genetic model analysis showed that rs2227478T>C and rs2227481C>T were significantly associated with a decreased risk of COPD under dominant models after adjusting for the above factors. In the recessive model, rs2227485T>C was obviously associated with decreased COPD risk. Our data showed that only rs2227485T>C was associated with a decreased COPD risk after Bonferroni correction. The eQTL analysis showed that rs2227485T>C was significantly associated with IL‐22 expression. The pGL4‐rs2227485‐C gene reporter had a higher promoter activity than pGL4‐rs2227485‐T. In our study, rs2227485T>C, located in the promoter region of IL‐22, was associated with a decreased risk of COPD and increased IL‐22 promoter activity, suggesting that this variant might modulate COPD susceptibility.

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“…Aljarba et al have reported that IL-22 polymorphisms in rs2227481 and rs2227483 are involved in the mounting of a protective immune response against Plasmodium falciparum infection. The authors also point out that the G allele of rs2227513 plays an important role in the increased production of IL-22 [73]. A recent study highlighted the role of IL-35 in malaria.…”

Section: Has An Anti-inflammatory Effect By Inhibiting Th1 Cell Differentiationmentioning

confidence: 94%

Recent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines

Popa

2021

Journal of Immunology Research

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Malaria is a serious and, in some unfortunate cases, fatal disease caused by a parasite of the Plasmodium genus. It predominantly occurs in tropical areas where it is transmitted through the bite of an infected Anopheles mosquito. The pathogenesis of malaria is complex and incompletely elucidated. During blood-stage infection, in response to the presence of the parasite, the host’s immune system produces proinflammatory cytokines including IL-6, IL-8, IFN-γ, and TNF, cytokines which play a pivotal role in controlling the growth of the parasite and its elimination. Regulatory cytokines such as transforming growth factor- (TGF-) β and IL-10 maintain the balance between the proinflammatory and anti-inflammatory responses. However, in many cases, cytokines have a double role. On the one hand, they contribute to parasitic clearance, and on the other, they are responsible for pathological changes encountered in malaria. Cytokine-modulating strategies may represent a promising modern approach in disease management. In this review, we discuss the host immune response in malaria, analyzing the latest studies on the roles of pro- and anti-inflammatory cytokines.

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Interleukin-22 Polymorphisms in Plasmodium falciparum-Infected Malaria Patients

Cited by 8 publications

References 36 publications

The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies

The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies

Identification of genetic variants of the IL‐22 gene in association with an altered risk of COPD susceptibility

Recent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines

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