Interleukin-1α and tumor necrosis factor-α protect cells against natural killer cell-mediated cytotoxicity and natural killer cytotoxic factor

Reiter, Zvi; Rubinstein, Menachem

doi:10.1016/0008-8749(90)90088-9

Cited by 14 publications

(7 citation statements)

References 42 publications

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“…The reveled mechanisms of NCT limitations [14,17] as well as the mechanisms preventing NK autocytotoxicity [18] are insufficient for induction and maintenance of dissociation in the NCT system. These mechanisms utilize active oxygen metabolites required for cytolysis [ 14,16] or dramatically attenuate the induction of cytotoxic factor production during programmed lysis of target cells [18,54,57]. Being involved in splitting of biological signal they also attenuate cytotoxic component of intercellular interactions, thus promoting synthetic and translational processes.…”

Section: Bulletin Of Experimental Biology and Medicine N O-12 1999rmentioning

confidence: 99%

Signal splitting as the basis for involvement of natural cytotoxicity system in endogenous biological retranslation

Чекнев

1999

Bull Exp Biol Med

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The ability of natural killers to split biological signal (dissociation of cytotoxic and interferon:producing activities) is the main precondition of the involvement of the natural cytotoxicity system in endogenous biological retranslation. Dissociation of the primary functions of natural cytotoxicity effectors is provided by enhanced interferon production against the background of decreased cytotoxicity of natural killers, or by enhanced natural cytotoxicity against the background of almost complete inhibition of interferon production. Dissociation of the primary functions of natural killers is a physiological phenomenon; it is induced and maintained by factors, which are not directly connected with induction or suppression of the immune response.

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Section: Bulletin Of Experimental Biology and Medicine N O-12 1999rmentioning

confidence: 99%

Signal splitting as the basis for involvement of natural cytotoxicity system in endogenous biological retranslation

Чекнев

1999

Bull Exp Biol Med

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“…The result of the reaction is thus determined by the factors which activate the lytic potential of NK by generating CFNK but which become involved as early as at the stage of recognition and TC binding. Interleukin (IL)-I~, tumor necrosis factor-~x [14], and interleuldn-6 [11] (potent stimulators of NK) do not affect the formation of T:E conjugates, confirming that such activity is an intrinsic property of the regulators of CFNK production or of the lytic potential of NK. Fraction A of glycoprotein isolated from the K-562 cell membrane can dissociate E:T conjugates [17]; however, this may represent a variant of nonspecific protection of TC, since incubation of lymphocytes v,~ith TC in the presence of this factor reduces NK activity by 50-60% [17].…”

Section: Resultsmentioning

confidence: 88%

Dissociation of E∶T conjugates upon activation of human natural killers by factors acting at the “lethal blow” stage

et al. 1994

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It is demonstrated that in the presence of human recombinant T-interferon and Creactive protein the activity of natural killers increases 9-43%, whereas the number of effector:target cell conjugates formed at the stage of recognizing and binding of target cells decreases 14-80%. There is a weak positive correlation (p =0.35) between the activity of natural killers and the number of effector:target cell conjugates,

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“…The fact that cytokine-stimulated PBMCs of our patients did not reach the respective normal NKa values is probably due to low numbers of NK cells included in PBMC suspensions tested. The possibility that some other liberated cytokines, such as IL-1a and TNF-a, may counteract the effect of cytolytic molecules [25] cannot be excluded, although it seems unlikely, since normal NK cells released functionally active mediators under the same experimental conditions.…”

Section: Discussionmentioning

confidence: 95%

Defective natural killer cell activity of peripheral blood lymphocytes correlates with the degree of neutropenia in patients with chronic idiopathic neutropenia of adults

Papadaki

Coulocheri

Xylouri

et al. 1998

Annals of Hematology

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Natural killer cell activity (Nka) of peripheral blood mononuclear cells (PBMCs) against K562 cell targets was assessed in 66 patients with chronic idiopathic neutropenia of adults (CINA) using the 16-h 51Cr-release assay. It was found that CINA patients exhibited significantly lower Nkr than normal subjects, which strongly correlated with the degree of neutropenia and the numbers of circulating neutrophils. Patients' NKa was increased by recombinant human interleukin-2 (rhIL-2) or recombinant human interferon-alpha (rhIFN-alpha), but the values obtained did not reach the respective NKa values found in normals. However, percentages of cytokine-induced rises of NKa did not differ statistically between patients and normal subjects. No serum inhibitors of NKa were demonstrated in our patients. CINA patients had low numbers of circulating NK cells as defined by the expression of NK-cell-related surface markers CD16, CD56, and CD57. CD16+ and CD56+, but not CD57+, cells correlated with the values of baseline NKa. The numbers of all these cell subsets correlated with the degree of neutropenia and the numbers of circulating neutrophils. Using CD56+-enriched PBL suspensions, it was shown that patients' NK cells displayed normal tumor cell binding capacity and produced in vitro normal amounts of natural killer cytotoxic factor(s) against K562 cell targets upon activation with rhIFN-alpha. Finally, percentages of perforin-expressing and granzyme B-expressing CD16+ cells did not differ statistically between patients and normal controls. Based on all these observations, we concluded that CINA patients display low NKa probably because they have low numbers of circulating NK cells. No functional abnormalities of NK cells were demonstrated. The cause and the underlying mechanisms leading to NK-cell depletion in these patients remain to be clarified.

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Interleukin-1α and tumor necrosis factor-α protect cells against natural killer cell-mediated cytotoxicity and natural killer cytotoxic factor

Cited by 14 publications

References 42 publications

Signal splitting as the basis for involvement of natural cytotoxicity system in endogenous biological retranslation

Signal splitting as the basis for involvement of natural cytotoxicity system in endogenous biological retranslation

Dissociation of E∶T conjugates upon activation of human natural killers by factors acting at the “lethal blow” stage

Defective natural killer cell activity of peripheral blood lymphocytes correlates with the degree of neutropenia in patients with chronic idiopathic neutropenia of adults

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